A5007168308- Nanoparticle-Based Drug Delivery
- Seaweed-derived Bioactive Compounds
- Proteoglycans and glycosaminoglycans research
- Marine Sponges and Natural Products
- Characterization and Applications of Magnetic Nanoparticles
- Glycosylation and Glycoproteins Research
- Natural Antidiabetic Agents Studies
- Sphingolipid Metabolism and Signaling
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Iron Metabolism and Disorders
- Magnetic Properties and Synthesis of Ferrites
- Computational Drug Discovery Methods
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Echinoderm biology and ecology
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Cynara cardunculus studies
- Nanocluster Synthesis and Applications
- Inhalation and Respiratory Drug Delivery
- Cell death mechanisms and regulation
- Blood properties and coagulation
La Rochelle Université
2017-2025
Centre National de la Recherche Scientifique
2017-2024
LIttoral ENvironnement et Sociétés
2016-2024
Centre d’études d’agents Pathogènes et Biotechnologies Pour la Santé
2020
Spanish National Centre for Cardiovascular Research
2014-2018
Centro de Investigación Biomédica en Red
2018
Instituto de Salud Carlos III
2014
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2014
Instituto de Química Orgánica General
2011
In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well release HS-bound signaling molecules, allowing cancer cell migration, invasion angiogenesis. Because their structural similarity HS, sulfated polysaccharides are considered a promising source molecules to control these activities. this study, we used depolymerisation method for producing λ-carrageenan oligosaccharides (λ-CO),...
Abstract Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used theranostics as contrast agents magnetic resonance imaging (MRI), catalase‐mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance properties these nanomaterials simultaneously. Herein, a cost‐efficient microwave method is developed manufacture ultrasmall manganese...
Controlling post-prandial hyperglycemia and hyperlipidemia, particularly by regulating the activity of digestive enzymes, allows managing type 2 diabetes obesity. The aim this study was to assess effects TOTUM-63, a formulation five plant extracts (Olea europaea L., Cynara scolymus Chrysanthellum indicum subsp. afroamericanum B.L.Turner, Vaccinium myrtillus Piper nigrum L.), on enzymes involved in carbohydrate lipid absorption. First, vitro inhibition assays were performed targeting three...
λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied synthesis stable NP incorporating both, ferrite cores divalent manganese (Mn2+) releasable ions. The acute pro-inflammatory behavior anticoagulant activity...
Atherosclerosis is a complex disease that can lead to life-threatening events, such as myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing plaque vulnerability remains challenging due lack effective diagnostic tools. Conventional protocols specificity fail predict type atherosclerotic lesion risk rupture. To address issue, technologies are emerging, noninvasive medical imaging with customized nanotechnological solutions. Modulating biological...
Multifunctional nanoparticles are usually produced by sequential synthesis, with long multistep protocols. Our study reports a generic modular strategy for the parallel one-step multifunctionalization of different hydrophobic nanoparticles. The method was designed and developed taking advantage natural noncovalent interactions between fatty acid binding sites bovine serum albumin (BSA) aliphatic surfactants on inorganic nanomaterials. As general example approach, three nanoparticles—iron...
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) are well-known for their anticoagulant properties. There is also currently a growing interest in using LMWH targeted cancer therapy. In particular, several types inhibit heparanase, key enzyme overexpressed the tumor microenvironment that promotes angiogenesis progression metastasis spreading. Here, we propose iron oxide nanoparticles (HEP-IONP) coated with different of distinct anticoagulant/anti-heparanase activity...
Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release thus playing a key role in angiogenesis metastasis. Here we propose new HS analogs as potent heparanase inhibitors: Heparin positive control, Dextran Sulfate, λ-Carrageenan, modified forms them obtained depolymerization associated to glycol splitting (RD-GS). After activity assessment, 11 kDa RD-GS-λ-Carrageenan...
Abstract We report the synthesis of micellar phosphatidylcholine‐coated superparamagnetic iron oxide nanoparticles as a new long circulation contrast agents for magnetic resonance imaging. Oleic acid‐coated Fe 3 O 4 were first prepared through thermal degradation and then encapsulated into small clusters with phosphatidylcholine coating to obtain hydrophilic nanomicelles. A thorough characterization confirmed chemical nature excellent colloidal stability these nanomicelles in aqueous media....
The synthesis and biological activity of oleylN-acetyl-α- β-d-glucosaminides (1 2, respectively) their thioglycosyl analogues (3 4, are reported. compounds exhibited antimitotic on rat glioma (C6) human lung carcinoma (A549) cell cultures in the micromolar range. Analysis extracts using ultra performance liquid chromatography-mass spectrometry showed that synthetic glycosides produce alterations glycosphingolipid metabolism, with variable effect level glucosylceramide depending configuration...
The coating composition of nanomedicines is one the main features in determining medicines' fate, clearance, and immunoresponse body. To highlight coatings' impact pulmonary administration, two micellar superparamagnetic iron oxide nanoparticles (SPION) were compared. These are similar size charge but have different coatings: either phosphatidylcholine (PC-SPION) or bovine serum albumin (BSA-SPION). aim study was to increase understanding nano-bio interaction with cellular non-cellular...
The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide (OA-IONP) with oleic acid coating and unique physicochemical properties the core. Some glycosides hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity cancer cells but reduced in vivo applications because intrinsic low solubility physiological media, are prone enzymatic hydrolysis. In this manuscript, we synthetized characterized...
Epstein-Barr virus (EBV) infects 95% of the world's population and persists latently in body. It immortalizes B-cells is associated with lymphomas. LCLs (lymphoblastoid cell lines, EBV latency III B-cells) inhibit anti-tumoral T-cell response following PD-L1 overexpression (programmed death-ligand 1 immune checkpoint). Many cancer cells, including some DLBCLs (diffuse large B-cell lymphomas), also overexpress PD-L1. Immunotherapies are based on inhibition PD-L1/PD-1 interactions but present...
The length of heparin oligosaccharides in the coating extremely small iron oxide nanoparticles can control core size during synthesis for optimal positive MRI contrast, endow probes with specific bioactivities and majorly impact <italic>in vivo</italic> pharmacokinetic properties.
Abstract In the present work, we describe development and characterization of a versatile smart coating containing an encapsulated inhibitor. This includes synthesis hollow spherical nanocapsules with diameters ranging from 180 to 200 nm. These particles are able release their payload when exposed alkaline environment, what could be induced by corrosion‐linked processes. A corrosion inhibitor, namely 2‐mercaptobenzothiazole has been encapsulated, after capsules were incorporated in...
Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide, and hypercholesterolemia a central risk factor for atherosclerosis. This study evaluated effects Totum-070, plant-based polyphenol-rich supplement, in hamsters with high-fat diet (HFD)-induced dyslipidemia. The molecular mechanisms action were explored using human Caco2 enterocytes. Totum-070 supplementation reduced total cholesterol (-41%), non-HDL (-47%), triglycerides (-46%) dose-dependent manner, compared...
Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis. However, non-enzymatic functions of HPSE also described tumour mechanisms. Given their versatile properties, we hypothesized that sugar-based inhibitors may interfere with but activities. In this work, assessed the effects an original marine...
Brown seaweeds of the Fucus genus represent a rich source natural antiviral products. In this study, ceranoides hydroalcoholic extract (FCHE) was found to inhibit 74.2 ± 1.3% proteolytic activity free SARS-CoV-2 3CL protease (3CLpro), an enzyme that plays pivotal role in polyprotein processing during coronavirus replication and has been identified as relevant drug discovery target for SARS- MERS-CoVs infections. To purify identify 3CLpro ligands with potential inhibitory using one-step...