A5077069563- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
- Surgical site infection prevention
- RNA Interference and Gene Delivery
- Hedgehog Signaling Pathway Studies
- Reconstructive Surgery and Microvascular Techniques
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Cell death mechanisms and regulation
- Molecular Communication and Nanonetworks
- Biomedical Ethics and Regulation
- Chemokine receptors and signaling
- Signaling Pathways in Disease
- Fibroblast Growth Factor Research
- Wound Healing and Treatments
- Cholesterol and Lipid Metabolism
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
Medical University of Silesia
2019-2024
Górnośląskie Centrum Medyczne
2021
University Medical Center Freiburg
2014-2017
University of Freiburg
2011-2017
Invasion and metastasis of carcinomas are often activated by induction aberrant epithelial-mesenchymal transition (EMT). This is mainly driven the transcription factor ZEB1, promoting tumor-initiating capacity correlated with increased expression putative stem cell marker CD44. However, direct link between CD44 tumourigenesis still enigmatic. Remarkably, EMT-induced repression ESRP1 controls alternative splicing CD44, causing a shift in from variant CD44v to standard CD44s isoform. We...
Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT mediated key transcription factors, including ZEB1, activated cell interactions with stromal and extracellular matrix (ECM). ZEB1-mediated motility accompanied substantial reprogramming acquisition a stemness phenotype. However, understanding underlying mechanism still incomplete. We identified hyaluronic acid (HA), one major...
Maintaining a balanced redox state within cells is crucial for the sustenance of life. The process involves continuous cytosolic disulfide reduction reactions to restore oxidized proteins their reduced thiol forms. There are two main cellular antioxidant pathways—the thioredoxin (Trx) and glutathione (GSH)/glutaredoxin (Grx) systems. In GSH/Grx system, reductase (GR; GSR) catalyses GSH (GSSG) its sulfhydryl form (GSH), which can then further reduce Grxs. GR an essential enzyme that helps in...
Glutaredoxin 2 (Grx2; Glrx2) is a glutathione-dependent oxidoreductase located in mitochondria, which central to the regulation of glutathione homeostasis and mitochondrial redox, plays crucial role highly metabolic tissues. In response redox signals oxidative stress, Grx2 can catalyze oxidation S-glutathionylation membrane-bound thiol proteins mitochondria. Therefore, it have significant impact on cancer development. To investigate this further, we performed an immunohistochemical analysis...
Introduction: The benefits of patient’s specific cell/gene therapy have been reported in relation to numerous genetic related disorders including osteogenesis imperfecta (OI). In particularly also a drug based on the administration bisphosphonates partially helped ease symptoms. Methods: this controlled trial, fibroblasts derived from patient diagnosed with OI type II successfully reprogrammed into induced Pluripotent Stem cells (iPSCs) using Yamanaka factors. Those were subjected repair...
Glutaredoxin 1 (Grx1) is an essential enzyme that regulates redox signal transduction and repairs protein oxidation by reversing S-glutathionylation, oxidative modification of cysteine residues. Grx1 removes glutathione from proteins to restore their reduced state (protein-SH) regulate protein-SSG levels in signaling networks. Thus, it can exert influence on the development cancer. To further investigate this problem, we performed analysis expression colon adenocarcinoma samples Polish...
Several studies revealed that expression levels of glutathione peroxidase 1 (Gpx-1) can be associated with cancer development, mainly through its role in hydroperoxide scavenging by regulating intracellular reactive oxygen species (ROS) levels. Therefore, our aim was to investigate the Gpx-1 protein a population Polish patients colon adenocarcinoma absence any therapy prior radical surgery. The study carried out using tissue from confirmed histopathological examination. antibody used...
Abstract Adamantinomatous craniopharyngioma (ACP) is an intracranial tumor considered partly malignant due to its ability infiltrate surrounding structures and tendency relapse despite radical resection. CD44 a known stem cell marker in ACP upregulated clusters of invasive protrusions; however, the functions alternative splicing isoform variants, CD44s CD44v1-10, have not yet been studied terms recurrence, their confirmed roles cancer development progression. In this study, we first...
Ischemic heart disease (IHD) is one of the main focuses in today’s healthcare due to its implications and complications, it predicted be increasing prevalence ageing population. Although conventional pharmacological interventional methods for treatment IHD presents with success clinical setting, long-term complications cardiac insufficiency are on a continual incline as result post-infarction remodeling tissue. The migration involvement stem cells muscle, followed by differentiation into...
Apoptosis is a widely controlled, programmed cell death, defects in which are the source of various diseases such as neurodegenerative well cancer. The use apoptosis therapy human increasing interest, and analysis factors involved its regulation valuable designing specific carriers capable targeting death. Highly efficient precisely controlled delivery genetic material by low-toxic one most important challenges apoptosis-based gene therapy. In this work, we investigate effect star polymer...
Median sternotomy is the surgical method of choice for many procedures where one main problems long post-operative wound healing process leading to sternal dehiscence and development infection. This leads prolonged hospital stay increased mortality due complications. A promising solution seems be use allogeneic chondrocytes treatment, whose properties in field cartilage reconstruction are widely used medicine, mainly orthopedics. In present study, we investigated effect local delivery on...
Stem cell treatment is a promising method of therapy for the group patients whose conventional options have been limited or rejected. cells potential to repair, replace, restore and regenerate cells. Moreover, their proliferation level high. Owing these features, they can be used in numerous diseases, such as cancer, lung diseases ischemic heart diseases. In recent years, stem has greatly developed, shedding light on stromal-derived factor 1α (SDF-1α). SDF-1α mobilizing chemokine application...
Abstract Invasion and metastasis of carcinomas are often promoted by the aberrant epithelial to mesenchymal transition (EMT) program at invasive front tumor. The transcription factor ZEB1 is a crucial promotor formation inducing EMT tumor initiating capacity. CD44, cell surface protein, used as marker identify cells in many cancer types. It involved cell-cell interactions, adhesion migration. Through alternative splicing, controlled splicing ESRP1, CD44 differentially regulated during EMT,...
Abstract The median sternotomy is the incision of choice for many procedures where one major problems long post-operative wound healing process leading to sternal dissection and development infection. This leads prolonged hospital stay increased mortality from complications. A promising solution appears be use allogeneic chondrocytes treatment, whose properties reconstruction cartilage structures are widely used in medicine, mainly orthopedics. In present study, we investigated effect local...