A5054046191- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Selenium in Biological Systems
- Theology and Canon Law Studies
- Liver physiology and pathology
- Public health and occupational medicine
- Drug-Induced Hepatotoxicity and Protection
- Tissue Engineering and Regenerative Medicine
- Mercury impact and mitigation studies
- Estrogen and related hormone effects
- Heavy Metal Exposure and Toxicity
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- Thallium and Germanium Studies
- Cancer Risks and Factors
- Geology and Environmental Impact Studies
- Endometrial and Cervical Cancer Treatments
- Nutrition and Health Studies
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Autism Spectrum Disorder Research
- Ovarian cancer diagnosis and treatment
- Magnesium in Health and Disease
- 14-3-3 protein interactions
Medical University of Silesia
2010-2024
Górnośląskie Centrum Medyczne
2012
It has been proved that nuclear factor-kappa B (NF-κB) is activated in all cells, promotes proliferation of regulates the immunological and inflammatory response, contribute to pathogenesis many conditions, including cancer. Many studies pointed constitutive activation NF-κB cells certain malignant tumors.The aim study was analyze role growth factor κB as colon cancer marker prognostic factor.The included 59 primary colorectal tumor patients 15 control group. The samples were taken during...
In this study the expression of GnRH, FSH, LH, ER- α , β and PR receptors was examined in uterine myomas women reproductive perimenopausal age. cases GnRH tropic hormones a membranous cytoplasmic immunohistochemical reaction detected, located cell nucleus, case it manifested also location. some detected endometrium, myocytes, endothelium blood vessels, glands myoma cells. myometrium level LH increases with age, whereas progesterone both estrogen decreases. independently their size, more...
Epithelial ovarian cancer represents one of the most deadly gynaecological neoplasms in developed countries and is a highly heterogeneous disease. Epidemiological studies show that anti-inflammatory drugs reduce incidence mortality several types cancer, indicating potential role pro-inflammatory factors carcinogenesis. The expression various types, including was assessed many studies, yielding consistent results, often due to histological heterogeneity cancers. aim study investigate IL-1,...
Background and Aims: Experimental models using carbon tetrachloride (CCl4) D-galactosamine (D-GalN) can be used in preclinical assessment of acute liver failure (ALF) therapies. Unfortunately, these are characterized by different dynamics injury depending on the animal strain, administered hepatotoxin, its dose. The aim this study was to compare known rat mouse ALF with a view their future introduction into cell therapy experiments. In particular, based histopathological molecular changes,...
Survivin is a member of the inhibitor apoptosis protein (IAP) family which are selectively overexpressed in human neoplasms, and its expression has been shown to be connected with cell proliferation. We analyzed survivin ovarian epithelial neoplasms evaluate role development tumors.Immunohistochemistry assays were conducted 137 cases (48 carcinoma, 43 borderline 46 benign tumor 20 samples normal tissue neoplasms. Histological types included serous (n = 68) mucinous 69) tumors. All tumors...
Uterine myomas represent one of the most common female diseases. or fibromas are benign, hormone-responding tumours of, respectively, smooth muscles and fibroblasts their aetiology induces a significant interest. In presence aromatase was detected and, in addition, oestrogen found to be synthesized myoma cells. The studies were performed on patients generative age those peri-menopausal age. Expression TRAF2 TRAF6 proteins examined using immunohistochemistry Western blot approach small large...
Uterine myomas represent one of the most common female pathologies. smooth muscle or fibromas are benign tumours which respond to hormones and their etiology induces wide interest. The were found contain aromatase and, in addition, cells synthesize estrogen. This study was conducted on patients with myomas, either generative age perimenopausal period. Expression detected various age, large small uterine using an immunohistochemical technique. In addition expression enzyme examined at...
Objectives:The aim of the study was to determine expression VEGF (vascular endothelial growth factor) isoforms and their receptors in uterine myomas. Material methods:The included 40 women with myomas reproductive age perimenopausal (the group).Myometrial samples control group) were taken from 10 undergoing hysterectomy for ovarian tumors older prolapse. Results:A significantly increased VEGF-A has been found myomas, both small large, younger women, which may by a sign angiogenesis intensive...
The route of administration implanted cells may affect the outcome cell therapy by directing migration to damaged site. However, question relationship between administration, efficacy colonisation a given organ, and has not been resolved. aim study was localise transplanted intravenously intraperitoneally human amniotic epithelial (hAECs) in tissues mice, both healthy injured, an animal experimental model acute liver failure (ALF). Mice intoxicated with D-Galactosamine (D-GalN) at dose 150...
Abstract In animal experimental models the administration of stem cells into spleen should ensure high effectiveness their implantation in liver due to a direct vascular connection between two organs. The aim this study was update methods intrasplenic cell transplantation using human amniotic epithelial (hAECs) which are promising treatment diseases. BALB/c mice were administered intrasplenically with 0.5, 1, and 2 million hAECs by bolus injection (400 µl/min) via subcutaneous splenic port...
Background: In humans, chronic liver disease (CLD) is a serious clinical condition with many life-threatening complications. Currently, there no therapy to stop or slow down the progression of fibrosis. Experimental mouse models CLD, induced by repeated intraperitoneal injections carbon tetrachloride (CCL4) and D-galactosamine (D-GalN), can be used evaluate therapies that cannot performed in humans. A major drawback these animal different dynamics fibrosis depending on strain, administered...
Median sternotomy is the surgical method of choice for many procedures where one main problems long post-operative wound healing process leading to sternal dehiscence and development infection. This leads prolonged hospital stay increased mortality due complications. A promising solution seems be use allogeneic chondrocytes treatment, whose properties in field cartilage reconstruction are widely used medicine, mainly orthopedics. In present study, we investigated effect local delivery on...
<h3>Background</h3> Brain-derived neurotrophic factor (BDNF) is a widespread cytokine, which may be found both in central nervous system and peripheral tissues. It plays multiple roles there are some literature suggestion that it involved HD pathophysiology. <h3>Aims</h3> To asses BDNF plasma level utility as biomarker. <h3>Methods</h3> The blood was collected from 42 patients vs 39 healthy control subject matching for age sex. Plasma of evaluated groups. All subjects went UHDRS evaluation....
Abstract The median sternotomy is the incision of choice for many procedures where one major problems long post-operative wound healing process leading to sternal dissection and development infection. This leads prolonged hospital stay increased mortality from complications. A promising solution appears be use allogeneic chondrocytes treatment, whose properties reconstruction cartilage structures are widely used in medicine, mainly orthopedics. In present study, we investigated effect local...