A5060496191- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Developmental Biology and Gene Regulation
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Thyroid Cancer Diagnosis and Treatment
- Redox biology and oxidative stress
- Inflammatory mediators and NSAID effects
- Glutathione Transferases and Polymorphisms
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Erythrocyte Function and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic factors in colorectal cancer
- Cardiac Arrhythmias and Treatments
- Systemic Lupus Erythematosus Research
- Diet, Metabolism, and Disease
- Peptidase Inhibition and Analysis
- Thyroid Disorders and Treatments
- TGF-β signaling in diseases
- Heat shock proteins research
- Ubiquitin and proteasome pathways
Medical University of Silesia
2013-2024
Kardio-Med Silesia
2024
Górnośląskie Centrum Medyczne
2018
Poznan University of Medical Sciences
2010-2017
University of Łódź
2013
Institute for Medical Biology
2013
Royal Marsden NHS Foundation Trust
1984
Royal Marsden Hospital
1984
National Cancer Center Hospital East
1984
University of Helsinki
1984
Maintaining a balanced redox state within cells is crucial for the sustenance of life. The process involves continuous cytosolic disulfide reduction reactions to restore oxidized proteins their reduced thiol forms. There are two main cellular antioxidant pathways—the thioredoxin (Trx) and glutathione (GSH)/glutaredoxin (Grx) systems. In GSH/Grx system, reductase (GR; GSR) catalyses GSH (GSSG) its sulfhydryl form (GSH), which can then further reduce Grxs. GR an essential enzyme that helps in...
Notch signaling pathway is activated dynamically during evolution playing significant role in cell fate determination and differentiation. It has been known that alterations of this may lead to human malignancies, including gastric cancer. Despite a decline the overall incidence, disease still remains an important global health problem. Therefore, better understanding molecular underlying cancer contribute development rationally designed targeted therapies. reported Notch1 receptor could...
Glutathione peroxidase 2 (Gpx-2) is a selenoenzyme with antioxidant capabilities that may play role in cancer development. Hence, we investigated the immunohistochemical expression of Gpx-2 protein colon adenocarcinoma samples derived from patients who did not receive any form treatment prior to surgical procedure. The associations between and clinical parameters were analysed using Chi2 test Fisher's exact test. A Kaplan-Meier analysis log-rank used verify relationship intensity 5-year...
Glutaredoxin 2 (Grx2; Glrx2) is a glutathione-dependent oxidoreductase located in mitochondria, which central to the regulation of glutathione homeostasis and mitochondrial redox, plays crucial role highly metabolic tissues. In response redox signals oxidative stress, Grx2 can catalyze oxidation S-glutathionylation membrane-bound thiol proteins mitochondria. Therefore, it have significant impact on cancer development. To investigate this further, we performed an immunohistochemical analysis...
Glutaredoxin 1 (Grx1) is an essential enzyme that regulates redox signal transduction and repairs protein oxidation by reversing S-glutathionylation, oxidative modification of cysteine residues. Grx1 removes glutathione from proteins to restore their reduced state (protein-SH) regulate protein-SSG levels in signaling networks. Thus, it can exert influence on the development cancer. To further investigate this problem, we performed analysis expression colon adenocarcinoma samples Polish...
Water-soluble polymer-drug conjugates were obtained and analyzed towards their potential use as prodrugs for two hydrophobic antipsoriatic agents, including methotrexate (MTX) acitretin (AC). The conjugation efficacy of MTX decreased with a decreasing molar ratio N,N-dimethylaminoethyl methacrylate (DMAEMA) repeating units in the polymethacrylic chains. Cytotoxicity positively charged (from +5 to +10 mV) nano- microparticles (3-1500 nm DMEM at 37 °C) estimated by vitro MTT Annexin-V...
Several studies revealed that expression levels of glutathione peroxidase 1 (Gpx-1) can be associated with cancer development, mainly through its role in hydroperoxide scavenging by regulating intracellular reactive oxygen species (ROS) levels. Therefore, our aim was to investigate the Gpx-1 protein a population Polish patients colon adenocarcinoma absence any therapy prior radical surgery. The study carried out using tissue from confirmed histopathological examination. antibody used...
Despite excellent results of bariatric surgery in the treatment type 2 diabetes and weight loss human subjects, some patients do not obtain desired results. One reasons for this is that all follow caloric intake recommendations.The aim study was to investigate effect duodenojejunal omega switch (DJOS) on body weight, glucose tolerance, incretins rats.DJOS SHAM were performed rats maintained 8 weeks high-fat diet (HF) control (CD), respectively. After surgery, four groups kept same as before...
The aim of the study was to assess expression and subcellular localization visfatin in HCT-116 colorectal carcinoma cells after cytokinesis failure using Cytochalasin B (CytB) mechanism apoptosis CytB. We observed translocation visfatin’s antigen cytB treated from cytosol nucleus. Statistical morphometric analysis revealed significantly higher area-related numerical density visfatin-bound nano-golds nuclei cytB-treated compared cytosol. Reverse relation un-treated cells. total amount...
Cardiovascular diseases account for a threefold higher mortality in women with Turner syndrome (TS). It has also been suggested that the occurrence of these is dependent on karyotype.To assess cardiovascular system by clinical examination, echocardiography and electrocardiography female patients TS, depending karyotype.Thirty-four aged 7-58 (35.2 +/-14.6) years, were evaluated. The categorized into 3 groups according to karyotype: group 1 comprised 12 monosomy X (45,X), 2 19 mosaicism,...
The Notch signalling pathway is one of the most conserved and well-characterised pathways involved in cell fate decisions development many diseases, including cancer. Among them, it worth noting Notch4 receptor its clinical application, which may have prognostic value patients with colon adenocarcinoma. study was performed on 129 adenocarcinomas. Immunohistochemical fluorescence expression using antibody. associations between IHC parameters were analysed Chi2 test or Chi2Yatesa test....
Nutritional status is a major determinant of hepatocyte injuries associated with changed metabolism and oxidative stress. This study aimed to determine the relations between stress, bariatric surgery, high-fat/high-sugar (HFS) diet in diet-induced obesity rat model. Male rats were maintained on control (CD) or inducing obesity. After 8 weeks, animals underwent SHAM (n = 14) DJOS surgery was either unchanged. Eight weeks after surgeries, activity superoxide dismutase isoforms (total SOD,...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Piecuch A, Kucharzewski M, Kurek J, Michalski Jasiński D, Brzozowa-Zasada M. The clinical significance of Notch1 immunoexpression in Caucasian patients with colorectal adenocarcinoma. Gastroenterology Review/Przegląd Gastroenterologiczny. 2020;15(4):314-322. doi:10.5114/pg.2020.101560. APA Piecuch, A., Kucharzewski, M., Kurek, J., Michalski, Jasiński, D., & Brzozowa-Zasada, (2020). Gastroenterologiczny, 15(4),...