A5037964937- Caveolin-1 and cellular processes
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Pancreatitis Pathology and Treatment
- Cardiovascular Health and Disease Prevention
- Cancer-related Molecular Pathways
- IgG4-Related and Inflammatory Diseases
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Neuroendocrine Tumor Research Advances
- 3D Printing in Biomedical Research
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cardiovascular Syncope and Autonomic Disorders
- Graphene research and applications
- HIV/AIDS oral health manifestations
- Diagnosis and treatment of tuberculosis
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Eicosanoids and Hypertension Pharmacology
- Biliary and Gastrointestinal Fistulas
- Infectious Diseases and Tuberculosis
University of Illinois Chicago
2020-2024
University of Illinois Urbana-Champaign
2020-2023
Hospital Nacional Cayetano Heredia
2016-2022
Cornell University
2017-2020
Autonomous University of Yucatán
2017
Institut de Recherche en Cancérologie de Montpellier
2010-2011
Charles R. Drew University of Medicine and Science
2011
Inserm
2007-2010
Université de Montpellier
2010
Délégation Paris 5
2007
Cell cycle regulators such as cyclins, cyclin-dependent kinases, or retinoblastoma protein play important roles in the differentiation of adipocytes. In present paper, we investigated role cyclin G2 a positive regulator adipogenesis. Cyclin is an unconventional which expression up-regulated during growth inhibition apoptosis. Using 3T3-F442A cell line, observed up-regulation at and mRNA levels throughout process differentiation, with further induction adipogenesis when transiently...
Abstract Endothelial stiffness is emerging as a major determinant in endothelial function. Here, we analyzed the role of caveolin-1 (Cav-1) determining cells (EC) exposed to oxidized low density lipoprotein (oxLDL) under static and hemodynamic conditions vitro aortic endothelium vivo mouse models dyslipidemia ageing. Elastic moduli cultured ECs monolayer freshly isolated aortas were measured using atomic force microscopy (AFM). We found that loss Cav-1 abrogates uptake oxLDL oxLDL-induced...
Hypercholesterolemia is a major risk factor for adverse cardiovascular outcomes, but its effect on angiogenesis and wound healing not well understood. In this study, using combination of mass spectrometry laurdan two-photon imaging, we show that elevated levels low-density lipoprotein (LDL), like those seen in hypercholesterolemic patients, lead to an increase both free cholesterol esters, as lipid order endothelial cell membranes. Notably, these effects are distinct opposite the lack...
Para lograr una mayor supervivencia de los implantes dentales, es importante sólida integración tejidos blandos en la región transmucosa con pilares protésicos. El objetivo este estudio fue evaluar si las superficies del pilar titanio recubiertas óxido grafeno mejoraban adhesión celular. Se ha demostrado que el favorece y estabilidad células componen periimplantarios, aumentando biocompatibilidad, celular propiedades antibacterianas titanio. En se recubrieron anodizados empresa Nobel...
Objective: To determine the impact of endothelial stiffening induced by CD36 (cluster differentiation 36) lipid uptake in development atherosclerosis. Approach and Results: Endothelial intact en face monolayers, as assessed atomic force microscopy, reveal hyperlipidemic mouse model atherosclerosis, LDLR -/- (low density lipoprotein receptor knockout) is significantly stiffer, especially atheroprone aortic arch, compared to wild type controls (n=4 male mice with 8-15 tissue measurement sites...
Introduction: Western diet (WD) associates with elevations in blood lipids. Endothelial cells (EC) uptake lipids through scavenger receptors such as CD36. In our studies we demonstrated that exposure to induces a stiffening response ECs, vivo showing this is abrogated mice global CD36 knockout. Hypothesis: WD aortic barrier disruption. vitro have EC correlates It hypothesis mediates WD-induced disruption an endothelial CD36-dependent manner. Methods: To generate model of endothelial-specific...
La Proteína C Reactiva (PCR) es una de las proteínas plasmáticas que aparecen en la fase aguda inflamación. periodontitis se relaciona con niveles elevados PCR adultos y reducción misma después su tratamiento. diabetes, por otro lado, enfermedad compromete respuesta tanto inflamatoria como reparativa del organismo los tejidos periodontales son particularmente sensibles a efecto. lo tanto, puede ser útil el diagnóstico determinación progresión periodontal (EP). El objetivo presente estudio...
Tuberculosis remains a public health concern in developing countries, as well developed countries result of immigration from endemic areas. Gastroduodenal and colorectal tuberculosis are rare manifestations gastrointestinal infection.We present 2 cases gastric, duodenal, tuberculosis. The first case, 17-year-old male with no medical record, presented chronic diarrhea abdominal pain. At endoscopy, he had multiple ulcers the stomach, colon, rectum, which were positive to Mycobacterium second...
La enteritis actinica cronica es un trastorno del intestino delgado que ocurre a partir de los 6 meses post radioterapia y se puede manifestar como malabsorcion, estenosis, formacion fistulas, abscesos locales, perforacion sangrado. Se reporta el caso una paciente adulta mayor la cual presento cuadro hemorragia digestiva origen oscuro (HDO) secundario actinica. Es mujer 64 anos con antecedente neoplasia maligna cervix quien recibio sesiones braquiterapia, ano despues dicho tratamiento...
ABSTRACT Background To determine the impact of endothelial stiffening induced by CD36-mediated lipid uptake in disruption aortic barrier and development atherosclerosis mouse models obesity hypercholesterolemia. Approach Results Endothelial-specific inducible downregulation CD36 results abrogating endothelium a short-term (6-8 weeks) high-fat Western diet intact freshly isolated aortas Cdh5.CreER T2 fl/fl mice, as assessed atomic force microscopy. No effect was observed on stiffness vascular...
Objective . This study compares low dose versus aggressive inhibition of the renin angiotensin system (RAS) to treat microalbuminuria (MA). Methods Patients with MA after a run-in period control BP <130/80 mm Hg 10 mg benazepril plus other drugs and HbA1c levels <8.0% were randomized either continue (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:mrow></mml:math>) or take maximal doses losartan in monthly...
The impact of a Western-style high fat diet (HFD) on cardiovascular health is chronic concern. Our previous studies showed that HFD results in significant endothelial cell (EC) stiffening, which was abrogated by the global deletion scavenger receptor Cd36. Here we present into role Cd36 EC stiffening and permeability mice fed short-term 6-8 weeks. Inducible EC-specific knockdown (EC-Cd36-KD) were generated crossing EC-promoter Cre with fl/fl mice. Knockdowns induced via tamoxifen injections...
La pancreatitis autoinmune tipo 1 es una enfermedad de baja prevalencia siendo mas frecuente en varones, se encuentra incluida dentro las enfermedades relacionadas a IgG4. Esta patologia puede debutar como un sindrome colestasico y el diagnostico realiza segun los criterios del consenso internacional para (ICDC) que incluye imagen tipica, serologia, compromiso otros organos, histologia respuesta al tratamiento con corticoides. Presentamos caso mujer 52 anos antecedente artritis reumatoide...
Abstract Muscle stem cells (MuSCs) are an essential cell population for skeletal muscle homeostasis and regeneration throughout adulthood. MuSCs ideal candidate therapies chronic acute injuries diseases given their inherent ability to self-renew generate progenitor capable of myogenic commitment fusion. Given rarity propensity lose stem-cell potential in prolonged culture, methods ex vivo MuSC expansion that achieve clinical-scale yields represent a critical unmet need cell-therapeutic...
The negative impacts of an enriched Western-style high-fat diet have been extensively interconnected with dyslipidemia. Our prior studies showed that feeding male mice (42% kcal from fat) results in significant cortical stiffening aortic endothelium and a global deletion CD36, scavenger receptor responsible for the uptake oxidized modifications LDL, abrogates this effect. We also previously exposing endothelial cells to oxLDL stiffening, effect mediated by CD36. Here we expand our determine...
Objective: Endothelial stiffness is emerging as a major determinant in endothelial function. Here, we analyzed the role of caveolin-1 (Cav-1) determining cells exposed to oxidized low density lipoprotein (oxLDL) under static and hemodynamic conditions vitro aortic endothelium vivo mouse models dyslipidemia ageing. Approach Results: Elastic moduli cultured monolayer freshly isolated aortas were measured using atomic force microscopy. We found that loss Cav-1 abrogates uptake oxLDL (n=5-8)...