A5079008889- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- RNA and protein synthesis mechanisms
- Plant Virus Research Studies
- interferon and immune responses
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Toxin Mechanisms and Immunotoxins
- Poxvirus research and outbreaks
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Immune Response and Inflammation
- Cardiomyopathy and Myosin Studies
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Veterinary medicine and infectious diseases
Jena University Hospital
2016-2025
Friedrich Schiller University Jena
2015-2024
Schiller International University
2000-2014
Institute of Virology of the Slovak Academy of Sciences
2000-2013
Center for Clinical Studies
2009
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2006
Escuela Nacional de Sanidad
2006
Instituto de Salud Carlos III
2006
University of Tübingen
1993-1998
Max Planck Institute of Biochemistry
1991-1993
The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera >75 species. Most the known picornaviruses infect mammals birds, but some have also been detected in reptiles, amphibians fish. Many are important human veterinary pathogens may cause diseases central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. transmitted by faecal-oral routes. This is a summary International Committee on...
Enteroviruses (EVs) and rhinoviruses (RVs) are significant pathogens of humans the subject intensive clinical epidemiological research public health measures, notably in eradication poliovirus investigation control emerging pathogenic EV types worldwide. EVs RVs highly diverse their antigenic properties, tissue tropism, disease associations evolutionary relationships, but latter often conflict with previously developed biologically defined terms, such as "coxsackieviruses", "polioviruses"...
The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in nucleoprotein (NP) pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer resistance. These resistance-associated amino acids NP differ between two but form a similar discrete surface-exposed cluster body domain NP, indicating resistance evolved independently. 1918 was conserved all descendent seasonal Introduction this into...
Infections with SARS-CoV-2 can be asymptomatic, but they also accompanied by a variety of symptoms that result in mild to severe coronavirus disease-19 (COVID-19) and are sometimes associated systemic symptoms. Although the viral infection originates respiratory system, it is unclear how virus overcome alveolar barrier, which observed COVID-19 disease courses. To elucidate effects on barrier integrity immune reactions, we used mono-cell culture systems complex human chip model composed...
In order to identify organ and cellular targets of persistent enterovirus infection in vivo, immunocompetent mice (SWR/J, H-2q) were inoculated intraperitoneally with coxsackievirus B3 (CVB3). By use situ hybridization for the detection enteroviral RNA, we show that CVB3 is capable inducing a multiorgan disease. During acute infection, viral RNA was visualized at high levels heart muscle, pancreas, spleen, lymph nodes comparably low central nervous system, thymus, lung, liver. At later...
PB1-F2 is a pro-apoptotic polypeptide of many influenza A virus (FLUAV) isolates encoded by an alternative ORF segment 2. comprehensive GenBank search was conducted to analyse its prevalence. This yielded 2226 entries 80 FLUAV subtypes. Of these sequences, 87 % encode greater than 78 aa. However, classic swine viruses and human H1N1 collected since 1950 harbour truncated sequence. While terminates after 57 aa, sequences have in-frame stop codons 11, 25 34 codons. the avian 96 full-length...
A series of 2-adamantanamines with alkyl adducts various lengths were examined for efficacy against strains influenza including those having an S31N mutation in M2 proton channel that confer resistance to amantadine and rimantadine. The addition as little one CH2 group the methyl adduct amantadine/rimantadine analogue, 2-methyl-2-aminoadamantane, led activity vitro two viruses A/Calif/07/2009 (H1N1) A/PR/8/34 but not a third A/WS/33 (H1N1). Solid state NMR transmembrane domain (TMD) site...
ABSTRACT Coxsackievirus B3 (CVB3) is a common factor in human myocarditis. Apoptotic events are present CVB3-induced disease, but it unclear how CVB3 involved apoptosis and which viral proteins may induce the apoptotic pathway. In this report we demonstrate that murine proapoptotic protein Siva specifically interact with capsid VP2. Furthermore, transcription of strongly induced tissue CVB3-infected mice same area positively stained for apoptosis, CD27, CD70. It has been proposed...
ABSTRACT Nucleotide sequencing and phylogenetic analysis of 10 recognized prototype strains the porcine enterovirus (PEV) cytopathic effect (CPE) group I reveals a close relationship viral genomes to previously sequenced strain F65, supporting concept reclassification this virus into new picornavirus genus. Also, nucleotide sequences polyprotein-encoding genome region or P1 28 historic recent field isolates were determined. The data suggest that several closely related but antigenically...
Background —Enteroviral ribonucleic acids have been identified in heart muscle of a subset patients with myocarditis and dilated cardiomyopathy as well mouse model persistent coxsackievirus B3 (CVB3) infection, suggesting that viral infection along activation an immune response may contribute to the pathogenesis ongoing cardiac disease certain patients. It is still not known whether persistence genome contributes cardiomyopathy. Methods Results —To determine low-level enteroviral gene...
The molecular classification of the porcine enterovirus (PEV) groups II and III was investigated. sequence almost complete PEV-8 (group II) genome reveals that this virus has unique L 2A gene regions. A reclassification group into a new picornavirus genus is suggested. PEV viruses are typical enteroviruses. They differ from other enteroviruses by prolonged stem-loop D 5'-cloverleaf structure.
Genetic analysis of the M2 sequence European porcine influenza A viruses reveals a high prevalence amantadine resistance due to substitution serine 31 by asparagine in all three circulating subtypes, H1N1, H3N2 and H1N2. The M segment resistant strains belongs single genetic lineage. Whereas first amantadine-resistant strain was isolated 1989, isolation last amantadine-susceptible dates 1987, suggesting displacement soon after emergence mutation. Analysis natural selection codon-based tests...
ABSTRACT Genotyping of 21 varicella-zoster virus (VZV) strains using a scattered single nucleotide polymorphism (SNP) method revealed ambiguous SNPs and two nontypeable isolates. For further genetic characterization, the genomes all were sequenced 454 technology. Almost-complete genome sequences assembled, most remaining gaps closed with Sanger sequencing. Phylogenetic analysis 42 five established novel VZV genotypes, provisionally termed VIII IX. Genotypes IX are distinct from previously...
The order Picornavirales represents a diverse group of positive-stranded RNA viruses with small non-enveloped icosahedral virions. Recently, bats have been identified as an important reservoir several highly pathogenic human viruses. Since many members the Picornaviridae family cause wide range diseases in humans and animals, this study aimed to characterize fruit bat populations located Southwest region Cameroon. These are frequently close contact due hunting, selling eating practices,...