A5100775026- Autophagy in Disease and Therapy
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Cannabis and Cannabinoid Research
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Genomics and Rare Diseases
- Structural Health Monitoring Techniques
- Ethics in Clinical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Advanced biosensing and bioanalysis techniques
- Heart Rate Variability and Autonomic Control
- Pharmaceutical Economics and Policy
- Ocular Disorders and Treatments
- Toxoplasma gondii Research Studies
- Childhood Cancer Survivors' Quality of Life
- Cardiac electrophysiology and arrhythmias
- Trace Elements in Health
- Ion Channels and Receptors
- Calcium signaling and nucleotide metabolism
- DNA and Nucleic Acid Chemistry
- Sirtuins and Resveratrol in Medicine
- Ophthalmology and Eye Disorders
University of Pennsylvania
2018-2023
Baylor College of Medicine
2023
American College of Medical Genetics
2023
University of Pennsylvania Health System
2020-2023
Rocky Vista University
2023
University of Utah
2016-2022
Doheny Eye Institute
2022
University of California, Irvine
2022
Swarthmore College
2018
Many primary sensory neurons are polymodal, responding to multiple stimulus modalities (chemical, thermal, or mechanical), yet each modality is recognized differently. Although polymodality implies that encoding occurs in higher centers, such as the spinal cord brain, recent neuron ablation studies find behavioral responses different require distinct subpopulations, suggesting existence of modality-specific labeled lines at level afferent. Here we provide evidence expressing TRPM8, a cold-...
Macroautophagy/autophagy is a key homeostatic process that targets cytoplasmic components to the lysosome for breakdown and recycling. Autophagy plays critical roles in glia neurons affect development, functionality, viability of nervous system. The mechanisms regulate autophagy neurons, however, are poorly understood. Here, we define molecular underpinnings primary cortical astrocytes response metabolic stress, perform comparative study hippocampal neurons. We find inducing stress by...
Technologies in genomic medicine have rapidly evolved and transformed the ability to deliver precision nearly every field of health care. As has advanced, electronic record (EHR) simultaneously been adopted into routine practice. A recent Points Consider Statement by American College Medical Genetics Genomics (ACMG) provides a framework for optimal integration data EHR.1.Grebe T.A. et al.The interface information with record: points consider statement (ACMG).10.1038/s41436-020-0841-2Genet....
<h3>Importance</h3> Statin therapy is underused for many patients who could benefit. <h3>Objective</h3> To evaluate the effect of passive choice and active interventions in electronic health record (EHR) to promote guideline-directed statin therapy. <h3>Design, Setting, Participants</h3> Three-arm randomized clinical trial with a 6-month preintervention period intervention. Randomization conducted at cardiologist level 16 cardiology practices Pennsylvania New Jersey. The study included 82...
Few cancer centers systematically engage patients with evidence-based tobacco treatment despite its positive effect on quality of life and survival. Implementation strategies directed at patients, clinicians, or both may increase use (TUT) within oncology.
Neurons and astrocytes face unique demands on their proteome to enable proper function survival of the nervous system. Consequently, both cell types are critically dependent robust quality control pathways such as macroautophagy (hereafter referred autophagy) ubiquitin-proteasome system (UPS). We previously reported that autophagy is differentially regulated in neurons context metabolic stress, but less understood proteotoxic stress induced by inhibition UPS. Dysfunction proteasome or has...
This study tests the hypothesis that amplitude modulation (AM) detection will be better under conditions where basilar membrane (BM) response growth is expected to linear rather than compressive. was tested by (1) comparing AM for a tonal carrier as function of level subjects with and without cochlear hearing impairment (HI), (2) carriers presented an ipsilateral notched-noise precursor, assumption precursor linearizes BM responses. Average thresholds were approximately 5 dB HI normal (NH)...
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures implicated in aging and human diseases, notably cancers. Because stabilization of GQs at telomeres oncogene promoters may prevent cancer, there is an interest developing small molecules that selectively target GQs. Herein, we investigate interactions meso-tetrakis-(4-carboxysperminephenyl)porphyrin (TCPPSpm4) its Zn(II) derivative (ZnTCPPSpm4) with telomeric (Tel22) via UV-Vis, circular dichroism...
Previous studies have attempted to explain age-related changes the orbit in isolation, often producing conflicting results. The authors used highly accurate imaging software analyze computed tomographic scans characterize related age objectively.In this case-control study, patients seen an ear, nose, and throat clinic were screened for study entry. Male female participants divided into two groups (20 30 years 60 75 years). Primary outcomes included measurement of bony orbital dimensions,...
PURPOSE To develop an electronic health record (EHR)–based clinical decision support (CDS) tool to promote guideline-recommended cancer risk management among patients with Lynch syndrome (LS), inherited that confers increased of colorectal and other types. MATERIALS AND METHODS We conducted a cross-sectional study determine the baseline prevalence predictors colonic surveillance annual genetics program visits LS. Multivariable log-binomial regressions estimated ratios (PRs) adherence by...
Motivation: Transcutaneous auricular vagus nerve stimulation (taVNS) has shown therapeutic efficacy in treating conditions such as epilepsy and depression. Recently, its potential to improve cognitive performance healthy adults been explored. Goal(s): However, little is known about the neurochemical processes underlying enhancing outcomes. This study assessed immediate residual effects of taVNS on activity brain regions associated with attention, vigilance, stress. Approach: Magnetic...
The ability of the auditory system to encode amplitude fluctuations a signal is important for processing complex stimuli, such as speech. A study by Florentine [Florentine et al., J. Acoust. Soc. Am. 81, 1528–1541 (1987)] measured intensity discrimination multiple frequencies function stimulus level. They observed that, high frequency difference limens were poorer at mid levels than higher or lower levels. This mid-level “hump” consistent with cochlear compression and suggests that may limit...
Abstract We consume fruits and vegetables every day without knowing whether or not agricultural residues (i.e. pesticides & heavy metals) are present on them. Current methods of residue detection easily accessible to the public inconvenient for everyday use. Thus, we want develop a convenient visualization by designing metal-binding pesticide-binding proteins along with colored that can directly interact these residues. worked including Bacterioferritin, MBP, Metallothionein, OprF. also...