A5008158617- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Oral health in cancer treatment
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Salivary Gland Disorders and Functions
- Bacterial Infections and Vaccines
- Dental Health and Care Utilization
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Antimicrobial Resistance in Staphylococcus
- CRISPR and Genetic Engineering
Tokyo Medical and Dental University
2017-2023
The University of Tokyo
2021
Peri-implantitis and periodontitis are both polymicrobial diseases induced by subgingival plaque accumulation, with some differing clinical features. Studies on the microbial gene transcription activity of peri-implantitis microbiota limited. This study aimed to verify hypothesis that disease-specific lead features, using an integrated metagenomic, metatranscriptomic, network analysis. Metagenomic data in were obtained from same 21 subjects metatranscriptomic 12 a database. The co-occurrence...
The characteristics of the periodontal microbiome influence clinical status. Gingivitis involves reversible gingival inflammation without alveolar bone resorption.
Deproteinized bovine bone or synthetic hydroxyapatite are 2 prevalent grafting materials used in the clinical treatment of peri-implant defects. However, differences formation among these remain unclear. This study evaluated osteogenesis kinetics defects using types deproteinized (Bio-Oss
Group A Streptococcus (GAS) is a major human pathogen, which associated with wide spectrum of invasive diseases, such as pharyngitis, scarlet fever, rheumatic and streptococcal toxic shock syndrome (STSS). It hypothesized that differences in GAS pathogenicity are related to the acquisition diverse bacteriophages (phages). Nevertheless, genome also harbors clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated (cas) genes, play an important role eliminating...
Periodontopathic bacteria Porphyromonas gingivalis in humans and gulae animals are phylogenetically close commonly have FimA Mfa1 fimbriae. However, little is known about how fimA mfa1 different between P. gulae. Here, we examined phylogenetic diversity their fim mfa gene clusters.Twenty strains were isolated from the periodontal pocket of 20 dogs. For genomic information, along with 64 11 genomes, relationship genotypes was examined. Variability amino acid sequences three-dimensional...
The oral bacterial species Porphyromonas gingivalis, a periodontal pathogen, has plastic genomes that may be driven by homologous recombination with exogenous deoxyribonucleic acid (DNA) is incorporated natural transformation and conjugation. However, bacteriophages plasmids, both of which are main resources DNA, do not exist in the known P. gingivalis genomes. This could associated an adaptive immunity system conferred clustered regularly interspaced short palindromic repeat (CRISPR)...
Abstract Background and Objective Dysbiosis, a loss of balance in the microbiota, is potential factor peri‐implantitis. However, compositional change peri‐implant microbiota soon after implant uncovering still unknown. In this study, bacterial composition sulcus was examined to understand establishment within during earliest weeks uncovering. Methods Microbiota samples were collected at 1, 2, 4, 6 stage‐two surgery. Bacterial DNA isolated from samples, 16S rRNA gene library constructed....