A5042353477- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Manufacturing Process and Optimization
- Nanofabrication and Lithography Techniques
- Cardiac Fibrosis and Remodeling
- Proteoglycans and glycosaminoglycans research
- Biomedical and Engineering Education
- Tendon Structure and Treatment
- Interdisciplinary Research and Collaboration
- Innovations in Medical Education
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
Stanford University
2019-2025
Swarthmore College
2024
Bioengineering Center
2024
Franciscan University of Steubenville
2022
King's College London
2018
Granular, microgel-based materials have garnered interest as promising tissue engineering scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these for 3D bioprinting, while maintaining sufficient void space enable migration, be challenging, since the rheological properties that determine printability are strongly influenced by microgel packing and fraction. In this work, a strategy is proposed decouple fraction blending UV-crosslinkable gelatin...
Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells' 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify pericellular space to suit needs, yet the dynamics reciprocal interactions with when encapsulated within remains relatively unexplored. Here, we show that human bone marrow stromal (hMSC) hyaluronic acid-based...
Human tissues, both in health and disease, are exquisitely organized into complex three-dimensional architectures that inform tissue function. In biomedical research, specifically drug discovery personalized medicine, novel human-based (3D) models needed to provide information with higher predictive value compared state-of-the-art two-dimensional (2D) preclinical models. However, current vitro remain inadequate recapitulate the heterogenous underlie biology. Therefore, it would be beneficial...
While the human body has many different examples of perfusable structures with complex geometries, biofabrication methods to replicate this complexity are still lacking. Specifically, fabrication self-supporting, branched networks multiple channel diameters is particularly challenging. Here, we present Gelation Uniform Interfacial Diffusant in Embedded 3D Printing (GUIDE-3DP) approach for constructing interconnected channels precise control over branching geometries and vessel sizes. To...
Abstract Advances in biofabrication have enabled the generation of freeform perfusable networks mimicking vasculature. However, key challenges remain effective endothelialization these complex, vascular-like networks, including cell uniformity, seeding efficiency, and ability to pattern multiple types. To overcome challenges, we present an integrated fabrication strategy directly generate branched, endothelial cell-lined using a diffusion-based, embedded 3D bioprinting process. In this...
Physical properties of modifiable hydrogels can be tuned to direct stem cell differentiation in a role akin that played by the extracellular matrix native niches. However, cells do not respond cues isolation, but rather integrate soluble and non-soluble signals balance quiescence, self-renewal differentiation. Here, we encapsulated single suspensions human mesenchymal (hMSC) hyaluronic acid-based at high low densities unravel contributions matrix- non-matrix-mediated directing response. We...
Blending sacrificial, cell-laden microgels with structural, UV-crosslinkable produces a family of modular bioinks tunable void fractions that influence cellular morphology while maintaining depth-independent cell distribution.
Abstract Graduate Teaching Assistants (TAs) have integral roles in teaching and cultivating classroom communities. By applying inclusive practices, TAs can promote a sense of community belonging within their departments through interactions with students, staff, faculty. Proper pedagogical training enables to clearly communicate graduate post-graduate careers, improve the quality undergraduate education, reduce time commitment for faculty instructors. Unfortunately, students STEM are often...
While the human body has many different examples of perfusable structures with complex geometries, biofabrication methods to replicate this complexity are still lacking. Specifically, fabrication self-supporting, branched networks multiple channel diameters is particularly challenging. Here, we present Gelation Uniform Interfacial Diffusant in Embedded 3D Printing (GUIDE-3DP) approach for constructing interconnected channels precise control over branching geometries and vessel sizes. To...