A5016684500- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Cancer, Lipids, and Metabolism
- Microbial Natural Products and Biosynthesis
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- RNA and protein synthesis mechanisms
- Cytokine Signaling Pathways and Interactions
- Environmental Toxicology and Ecotoxicology
- Mosquito-borne diseases and control
- thermodynamics and calorimetric analyses
- HIV/AIDS drug development and treatment
- Heavy Metal Exposure and Toxicity
- Microtubule and mitosis dynamics
- Viral gastroenteritis research and epidemiology
- Free Radicals and Antioxidants
- Mercury impact and mitigation studies
- Protein Structure and Dynamics
- Malaria Research and Control
- Cancer therapeutics and mechanisms
- Natural product bioactivities and synthesis
University of Calcutta
2018-2024
Regional Medical Research Centre
2015
Indian Council of Medical Research
2015
The present investigation was executed to reveal the protective mechanism of rosmarinic acid (RA) against cadmium (Cd)-induced nephrotoxicity. RA exhibited a concentration-dependent anti-apoptotic effect CdCl2 in isolated mouse proximal tubular epithelial cells. Cd treatment significantly (p < 0.01) imparted oxidative stress renal cells via excessive ROS production, triggering NO level, NADPH oxidase activation, and impairment cellular redox defense system. Cd-mediated endorsed apoptosis...
Tuberculosis has been a challenge to the world since prehistoric times, and with advent of drug-resistant strains, it become more challenging treat this infection. Ethionamide (ETH), second-line drug, acts as prodrug targets mycolic acid synthesis by targeting enoyl-acyl carrier protein reductase (InhA) enzyme.
Cadmium (Cd) imparts nephrotoxicity via triggering oxidative stress and pathological signal transductions in renal cells. The present study was performed to explore the protective mechanism of carnosic acid (CA), a naturally occurring antioxidant compound, against cadmium chloride (CdCl2)-provoked employing suitable vitro vivo assays. CA (5 µM) exhibited an anti-apoptotic effect CdCl2 (40 normal kidney epithelial (NKE) cells evidenced from cell viability, image, flow cytometry In this study,...
The present study evaluated the therapeutic potential of myricitrin (Myr), a glycosyloxyflavone extracted from Myrica esculenta bark, against diabetic nephropathy. Myr exhibited significant hypoglycemic effect in high fat-fed and single low-dose streptozotocin-induced type 2 (T2D) rats. was found to improve glucose uptake by skeletal muscle via activating IRS-1/PI3K/Akt/GLUT4 signaling vitro vivo. significantly attenuated (HG)-induced toxicity NRK cells kidneys T2D In this study,...
Introduction: SYK (Spleen Tyrosine Kinase) regulates immune response and is a promising target for cancer, sepsis, allergy therapies. This study aims to create novel compounds that serve as alternative inhibitors cancer treatments targeting SYK. Method: A thorough combination of machine learning (ML) physics-based methods was employed achieve these goals, encompassing de novo design, multitier molecular docking, absolute binding affinity computation, dynamics (MD) simulation. Results: total...
The present studies have been executed to explore the protective mechanism of carnosic acid (CA) against NaAsO 2 ‐induced hepatic injury. CA exhibited a concentration dependent (1–4 μ M) increase in cell viability (12 murine hepatocytes. treatment significantly enhanced ROS‐mediated oxidative stress cells both vitro and vivo systems. Significant activation MAPK, NF‐ κ B, p53, intrinsic extrinsic apoptotic signaling was observed ‐exposed cells. could counteract with redox thereby attenuated...
Tuberculosis (TB) is one of the major public health concerns in Assam, a remote state located northeastern (NE) region India. The present study was undertaken to explore circulating genotypes Mycobacterium tuberculosis complex (MTBC) this region. A total 189 MTBC strains were collected from smear positive pulmonary cases different designated microscopy centres (DMC) various localities Assam. All isolates cultured on Lowenstein-Jensen (LJ) media and subsequently genotyped using spoligotyping...
Worldwide coronavirus disease 2019 (COVID-19) outbreak is still threatening global health since its first reported in the late 2019. The causative novel virus has been designated as severe acute respiratory syndrome 2 (SARS-CoV-2). Although COVID-19 emergent with significant mortality, there no availability of definite treatment measures. It now extremely desirable to identify potential chemical entities against SARS-CoV-2 for COVID-19. In present study, a state-of-art virtual screening...
Abstract Dengue infection is the most common arthropod‐borne disease caused by dengue viruses, predominantly affecting millions of human beings annually. To find out promising chemical entities for therapeutic application in Dengue, current research, a multi‐step virtual screening effort was conceived to screen entire “screening library” Asinex database. Initially, through “Lipinski rule five” filtration criterion almost 0.6 million compounds were collected and docked with NS3‐NS2B protein....
Drug resistance is an unsolved and major concern in the bacterial infection. Continuous development of drug-resistance to antibiotics exponentially rises danger infections. Chemical components from plants are becoming a resource potentially effective therapeutic chemical agents for wide range diseases including In current study, pharmacoinformatics methodologies were implemented on more than two hundred known phytochemicals find promising beta-lactamase inhibitors therapeutically...
Histone deacetylase 8 (HDAC8) has emerged as a promising drug target for cancer therapeutics development. HDAC8 been reported to regulate cell proliferation, invasion and promote metastasis through modulation of cycle associated proteins. Of late, phytocompounds have demonstrated exhibit anticancer anti-HDAC8 activity. Here, we shown the inhibitory potential an active phytocompound from HC9 (herbal composition-9), polyherbal formulation based on traditional Ayurvedic drug, Stanya Shodhan...
The protein-protein interactions (PPIs) in the biological systems are important to maintain a number of cellular processes. Several disorders including cancer may be developed due dysfunction assembly PPI networks. Hence, targeting intracellular PPIs can considered as crucial drug target for therapy. Among enormous and diverse group cancer-enabling PPIs, Hsp90-Cdc37 is prominent therapeutic development. successful inhibition interface an option management. In current study, set more than...
Abstract Thymidylate kinase (TMK) is a pivotal enzyme in Mycobacterium tuberculosis (Mtb), crucial for phosphorylating thymidine monophosphate (dTMP) to diphosphate (dTDP), thereby playing critical role DNA biosynthesis. Dysregulation or inhibition of TMK activity disrupts replication and cell division, making it an attractive target anti-tuberculosis drug development. In this study, the statistically validated pharmacophore mode was developed from set known inhibitors. Further, robust...