A5077571004- Computational Drug Discovery Methods
- Synthesis and biological activity
- Free Radicals and Antioxidants
- Estrogen and related hormone effects
- Cholinesterase and Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Analytical Methods in Pharmaceuticals
- Protease and Inhibitor Mechanisms
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Chemical Thermodynamics and Molecular Structure
- Protein Structure and Dynamics
- Inflammatory mediators and NSAID effects
- Analytical Chemistry and Chromatography
- Vitamin C and Antioxidants Research
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Plant biochemistry and biosynthesis
University of Calcutta
2016-2025
Adamas University
2023
Ramakrishna Mission Vidyamandira
1999-2002
In the present work, quantitative structure–activity relationship (QSAR) models have been built for a wide variety of antioxidant phenolic compounds obtained from traditional Chinese medicinal plants, with their Trolox equivalent capacity measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS√+) assay methods. Non-linear genetic partial least-squares technique were acceptable both in terms internal external predictivity....
The present investigation was executed to reveal the protective mechanism of rosmarinic acid (RA) against cadmium (Cd)-induced nephrotoxicity. RA exhibited a concentration-dependent anti-apoptotic effect CdCl2 in isolated mouse proximal tubular epithelial cells. Cd treatment significantly (p < 0.01) imparted oxidative stress renal cells via excessive ROS production, triggering NO level, NADPH oxidase activation, and impairment cellular redox defense system. Cd-mediated endorsed apoptosis...
Persistent hyperglycemia, impairment of redox status and establishment inflammatory pathophysiology integrally play important role in the pathogenesis diabetic cardiomyopathy (DC). Present study examined therapeutic potential protocatechuic acid isolated from Sansevieria roxburghiana rhizomes against DC employing rodent model type 2 diabetes (T2D). T2D was induced by high fat diet + a low-single dose streptozotocin (35 mg/kg, i.p.). rats exhibited significantly (p < 0.01) fasting blood...
Recent analyses have highlighted the promotion of cancer migration and invasion, mediated through HDAC <italic>via</italic> MMP-2 MMP-9.
Cadmium (Cd) imparts nephrotoxicity via triggering oxidative stress and pathological signal transductions in renal cells. The present study was performed to explore the protective mechanism of carnosic acid (CA), a naturally occurring antioxidant compound, against cadmium chloride (CdCl2)-provoked employing suitable vitro vivo assays. CA (5 µM) exhibited an anti-apoptotic effect CdCl2 (40 normal kidney epithelial (NKE) cells evidenced from cell viability, image, flow cytometry In this study,...
The present study evaluated the therapeutic potential of myricitrin (Myr), a glycosyloxyflavone extracted from Myrica esculenta bark, against diabetic nephropathy. Myr exhibited significant hypoglycemic effect in high fat-fed and single low-dose streptozotocin-induced type 2 (T2D) rats. was found to improve glucose uptake by skeletal muscle via activating IRS-1/PI3K/Akt/GLUT4 signaling vitro vivo. significantly attenuated (HG)-induced toxicity NRK cells kidneys T2D In this study,...
The present studies have been executed to explore the protective mechanism of carnosic acid (CA) against NaAsO 2 ‐induced hepatic injury. CA exhibited a concentration dependent (1–4 μ M) increase in cell viability (12 murine hepatocytes. treatment significantly enhanced ROS‐mediated oxidative stress cells both vitro and vivo systems. Significant activation MAPK, NF‐ κ B, p53, intrinsic extrinsic apoptotic signaling was observed ‐exposed cells. could counteract with redox thereby attenuated...
Engaging Raman spectroscopy as a primary tool, we investigated the early events of insulin fibrilization and determined structural content present in oligomer protofibrils that are formed intermediates fibril formation pathway. Insulin oligomer, obtained upon incubation zinc-free at 60 °C, was mostly spherical shape, with diameter 3–5 nm. Longer produced "necklace"-like beaded protofibrillar assembly species. These eventually transformed into 5–8 nm thick fibers smooth surface texture. A...
Lysozyme, like many other well-folded globular proteins, under stressful conditions produces nanoscale oligomer assembly and amyloid-like fibrillar aggregates. With engaging Raman microscopy, we made a critical structural analysis of structures lysozyme obtained from hen egg white provided quantitative estimation protein secondary structure in different states its fibrillation. A strong amide I band at 1660 cm–1 N–Cα–C stretching ∼930 clearly indicated the presence substantial amount...
Worldwide coronavirus disease 2019 (COVID-19) outbreak is still threatening global health since its first reported in the late 2019. The causative novel virus has been designated as severe acute respiratory syndrome 2 (SARS-CoV-2). Although COVID-19 emergent with significant mortality, there no availability of definite treatment measures. It now extremely desirable to identify potential chemical entities against SARS-CoV-2 for COVID-19. In present study, a state-of-art virtual screening...
Abstract Background Acute lung injury (ALI) is caused by bacterial, fungal, and viral infections. When pathogens invade the lungs, immune system responds producing cytokines, chemokines, interferons to promote infiltration of phagocytic cells, which are essential for pathogen clearance. Their excess production causes an overactive response a pathological hyper‐inflammatory state, leads ALI. Until now, there no particular pharmaceutical treatment available ALI despite known inflammatory...