A5011229638- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- Heavy Metal Exposure and Toxicity
- Ethnobotanical and Medicinal Plants Studies
- Moringa oleifera research and applications
- Phytochemicals and Medicinal Plants
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Heavy Metals in Plants
- Arsenic contamination and mitigation
- Chemotherapy-induced cardiotoxicity and mitigation
- Saffron Plant Research Studies
- Nanoparticle-Based Drug Delivery
- Chemotherapy-induced organ toxicity mitigation
- Phytochemistry and Bioactivity Studies
- Medicinal Plants and Neuroprotection
- Nanoplatforms for cancer theranostics
- Polysaccharides Composition and Applications
- Food composition and properties
- Nanocomposite Films for Food Packaging
North Bengal University
2020-2025
Jadavpur University
2013-2024
Advanced Pharma
2018
Abroma augusta L. (Malvaceae) leaf is traditionally used to treat diabetes in India and Southern Asia. Therefore, current study was performed evaluate the protective effect of defatted methanol extract A. leaves (AA) against type 2 mellitus (T2DM) its associated nephropathy cardiomyopathy experimental rats.Antidiabetic activity AA extracts (100 200 mg/kg, p.o.) measured streptozotocin-nicotinamide induced diabetic (T2D) rat. Fasting blood glucose level (at specific interval) serum...
The present investigation was executed to reveal the protective mechanism of rosmarinic acid (RA) against cadmium (Cd)-induced nephrotoxicity. RA exhibited a concentration-dependent anti-apoptotic effect CdCl2 in isolated mouse proximal tubular epithelial cells. Cd treatment significantly (p < 0.01) imparted oxidative stress renal cells via excessive ROS production, triggering NO level, NADPH oxidase activation, and impairment cellular redox defense system. Cd-mediated endorsed apoptosis...
Persistent hyperglycemia, impairment of redox status and establishment inflammatory pathophysiology integrally play important role in the pathogenesis diabetic cardiomyopathy (DC). Present study examined therapeutic potential protocatechuic acid isolated from Sansevieria roxburghiana rhizomes against DC employing rodent model type 2 diabetes (T2D). T2D was induced by high fat diet + a low-single dose streptozotocin (35 mg/kg, i.p.). rats exhibited significantly (p < 0.01) fasting blood...
In the present study, we aimed to investigate antioxidant, cytotoxicity activities, and phytochemical profiling of O. stellata extracts. Qualitative tests showed presence different groups phytochemicals, mainly in polar solvents. Methanolic hydroalcoholic extracts high total phenolic flavonoid contents. The antioxidant activity was determined by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), metal chelating, reducing power assay where methanolic (IC50: 24.76 ± 2.78 μg/mL), 29.59 3.44 aqueous...
Ipomea aquatica (Convolvulaceae) is traditionally used against Arsenic (As) poisoning in folk medicines India. The present study was designed to explore the therapeutic role of aqueous extract I. (AEIA) As-intoxication.AEIA chemically standardized by spectroscopic and chromatographic analysis. cytoprotective AEIA measured on isolated murine hepatocytes. effect redox status were after incubating hepatocytes with NaAsO2 (10 μM) + (400 μg/ml). protective μg/ml) expressions apoptotic proteins...
Cadmium (Cd) imparts nephrotoxicity via triggering oxidative stress and pathological signal transductions in renal cells. The present study was performed to explore the protective mechanism of carnosic acid (CA), a naturally occurring antioxidant compound, against cadmium chloride (CdCl2)-provoked employing suitable vitro vivo assays. CA (5 µM) exhibited an anti-apoptotic effect CdCl2 (40 normal kidney epithelial (NKE) cells evidenced from cell viability, image, flow cytometry In this study,...
The present study evaluated the therapeutic potential of myricitrin (Myr), a glycosyloxyflavone extracted from Myrica esculenta bark, against diabetic nephropathy. Myr exhibited significant hypoglycemic effect in high fat-fed and single low-dose streptozotocin-induced type 2 (T2D) rats. was found to improve glucose uptake by skeletal muscle via activating IRS-1/PI3K/Akt/GLUT4 signaling vitro vivo. significantly attenuated (HG)-induced toxicity NRK cells kidneys T2D In this study,...
Abstract Asparagus racemosus Willd., a significant medicinal plant in India’s Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of aerial part Willd. utilizing streptozotocin-nicotinamide-induced diabetic rat model. methanolic extract (ARME) was evaluated for vitro activity through α-glucosidase and α-amylase enzyme suppression assay assessed vivo streptozotocin-induced A 21-day chronic multiple-dose ARME examined. STZ-induced rats were treated with...
Ipomoea aquatica (Convolvulaceae) and Enhydra fluctuans (Asteraceae), two aquatic vegetables, are traditionally used against heavy metal toxicity in traditional medicines India. The present study aimed to explore the protective role of edible (aqueous) extracts I. (AEIA) E. (AEEF) Cd-intoxication. were chemically standardized by spectroscopic HPLC analysis. cytoprotective roles AEIA AEEF measured on mouse hepatocytes. effect redox status after incubating hepatocytes with CdCl2 (30 μM) along...