A5024522579- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Decision-Making and Behavioral Economics
- Visual perception and processing mechanisms
- Neuroscience and Music Perception
- Complex Systems and Decision Making
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Action Observation and Synchronization
- Personality Disorders and Psychopathology
- Neural Networks and Applications
- Experimental Behavioral Economics Studies
- Cognitive Science and Mapping
- Reading and Literacy Development
- Tactile and Sensory Interactions
- Stress Responses and Cortisol
- Cognitive Science and Education Research
- Blind Source Separation Techniques
- Autism Spectrum Disorder Research
- Olfactory and Sensory Function Studies
- Opinion Dynamics and Social Influence
- Machine Learning and Data Classification
University of Oxford
2014-2024
Wellcome Centre for Integrative Neuroimaging
2013-2024
Warneford Hospital
2020-2023
University of Cambridge
2006-2022
John Radcliffe Hospital
2008-2021
University College London
2012-2020
Wellcome Centre for Human Neuroimaging
2012-2020
National Health Service
2018
Sobell House
2013-2018
Oxford Health NHS Foundation Trust
2018
Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination activity between brain areas during cognitive tasks. Therefore, ongoing ascribed to different functional networks should also be able reorganise coordinate via similar mechanisms. We develop a novel method identifying large-scale phase-coupled network dynamics show that resting in magnetoencephalography well characterised by visits short-lived transient states, with...
SummaryAdaptive success in social animals depends on an ability to infer the likely actions of others. Little is known about neural computations that underlie this capacity. Here, we show brain models values and choices others even when these are currently irrelevant. These modeled use same our own choices, but resolved a distinct neighboring medial prefrontal region. Crucially, however, subjects choose behalf partner instead themselves, regions exchange their functional roles. Hence,...
Abstract Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons or dynamic (time-varying) across a neural population. Here, we compare these hypotheses four regions of prefrontal cortex (PFC) an oculomotor-delayed-response task, where intervening cue indicated the reward available for correct saccade. WM representations were strongest ventrolateral PFC with higher intrinsic temporal stability (time-constant). At population-level,...
Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates chosen a consequence varying rates dynamical evidence accumulation process. Yet within PFC, there is substantial variability across individual neurons. Here show this explained by neurons having different temporal receptive fields integration, indexed examining neuronal spike rate autocorrelation structure whilst...
Reward prediction error (RPE) signals are central to current models of reward-learning. Temporal difference (TD) learning posit that these should be modulated by predictions, not only magnitude but also timing reward. Here we show BOLD activity in the VTA conforms such TD predictions: responses unexpected rewards a temporal hazard function and between predictive stimulus reward is depressed proportion predicted By contrast, ventral striatum (VS) does reflect RPE, instead encodes signal on...
Activity in prefrontal cortex (PFC) has been richly described using economic models of choice. Yet such descriptions fail to capture the dynamics decision formation. Describing dynamic neural processes proven challenging due problem indexing internal state PFC and its trial-by-trial variation. Using primate neurophysiology human magnetoencephalography, we here recover a single-trial index states from multiple simultaneously recorded subregions. This can explain origins representations...
Information sampling is often biased towards seeking evidence that confirms one's prior beliefs. Despite such biases being a pervasive feature of human behavior, their underlying causes remain unclear. Many accounts these appeal to limitations hypothesis testing and cognition, de facto evoking notions bounded rationality, but neglect more basic aspects behavioral control. Here, we investigated potential role for Pavlovian approach in biasing which information humans will choose sample. We...
Two long-standing traditions have highlighted cortical decision mechanisms in the parietal and prefrontal cortices of primates, but it has not been clear how these processes differ, or when each region may influence behaviour. Recent data from ventromedial cortex (vmPFC) posterior (PPC) suggested one possible axis on which two might be delineated. Fast decisions resolved primarily by mechanisms, whereas made without time pressure rely mechanisms. Here, we report direct evidence for such...
Abstract Many studies report atypical responses to sensory information in autistic individuals, yet it is not clear which stages of processing are affected, with little consideration given decision-making processes. We combined diffusion modelling high-density EEG identify differ between 50 and typically developing children aged 6–14 years during two visual motion tasks. Our pre-registered hypotheses were that would show task-dependent differences evidence accumulation, alongside a more...
Abstract The relationship between the geometry of neural representations and task being performed is a central question in neuroscience 1–6 . primate prefrontal cortex (PFC) primary focus inquiry this regard, as under different conditions, PFC can encode information with geometries that either rely on past experience 7–13 or are agnostic 3,14–16 One hypothesis should evolve learning 4,17,18 , from format supports exploration all possible rules to minimises encoding task-irrelevant features...
Working memory has been traditionally studied as a passive storage for information. However, recent advances have suggested that working is prospective rather than retrospective, meaning its content undergoes transformations will support future behaviour. One perspective underscores this notion conceptualises processes computational resource can be used to reduce the complexity of computation at decision time. Here, we explore by examining whether process maintenance shapes neural geometry...
A central question in cognitive neuroscience regards the means by which options are compared and decisions resolved during value-guided choice. It is clear that several component processes needed; these include identifying options, a value-based comparison, implementation of actions to execute decision. What less temporal precedence functional organisation brain. Competing models decision making have proposed value comparison may occur space alternative actions, or abstract goods. We...
In decision making, dorsal and ventral medial prefrontal cortex show a sensitivity to key variables, such as reward prediction errors. It is unclear whether these signals reflect parallel processing of common synchronous input both regions, for example from mesocortical dopamine, or separate consecutive stages in processing. These two perspectives make distinct predictions about the relative timing feedback-related activity each question we address here. To reconstruct unique temporal...