A5025358774- Genetics and Neurodevelopmental Disorders
- Geological and Geophysical Studies
- earthquake and tectonic studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Geological formations and processes
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Geological and Tectonic Studies in Latin America
- Seismic Imaging and Inversion Techniques
- Geophysics and Gravity Measurements
- Geological and Geochemical Analysis
- Autism Spectrum Disorder Research
- Ubiquitin and proteasome pathways
- Reservoir Engineering and Simulation Methods
- High-pressure geophysics and materials
- Phosphodiesterase function and regulation
- Single-cell and spatial transcriptomics
- Adenosine and Purinergic Signaling
- Hydrocarbon exploration and reservoir analysis
- Antimicrobial Peptides and Activities
- Structural Health Monitoring Techniques
- Landslides and related hazards
- Synthetic Aperture Radar (SAR) Applications and Techniques
Université Côte d'Azur
2009-2023
Centre National de la Recherche Scientifique
2009-2023
Institut de Pharmacologie Moléculaire et Cellulaire
2009-2023
Total (Belgium)
2022
Total (France)
2015-2018
Observatoire de la Côte d’Azur
2017-2018
CEA LETI
2018
CEA Grenoble
2018
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2018
Université Grenoble Alpes
2018
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that function as gene regulators and a host cell defense against both RNA DNA viruses. We provide evidence for physiological role the miRNA-silencing machinery in controlling HIV-1 replication. Type III RNAses Dicer Drosha, responsible miRNA processing, inhibited virus replication peripheral blood mononuclear cells from HIV-1–infected donors latently infected cells. In turn, actively suppressed expression...
Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor substrates the Drosha and Dicer RNase III enzymes. Several variant pathways exploit other RNA metabolic activities to generate functional miRNAs. However, all these culminate in cleavage, suggesting that this is a unifying feature miRNA biogenesis. Here, we show maturation miR-451, perfectly conserved among vertebrates, independent Dicer. Instead, structure-function knockdown studies indicate generates...
The northern Sunda subduction zone, offshore Burma, and the associated Indo‐Burmese Wedge mark active eastern boundary of Burma Platelet jammed between India Plate Plate. aim this paper is to provide a structural kinematics analysis based on seismic reflection, geodetic, geological field data. We found out that place diffuse strain partitioning: right‐lateral shearing in innermost part E‐W shortening outermost part. In outer wedge, thick‐skinned deformation overprints thin‐skinned...
Epithelial-mesenchymal interactions are critical in regulating many aspects of vertebrate embryo development, and for the maintenance homeostatic equilibrium adult tissues. The between epithelium mesenchyme believed to be mediated by paracrine signals such as cytokines extracellular matrix components secreted from fibroblasts that affect adjacent epithelia. In this study, we sought identify repertoire microRNAs (miRNAs) normal lung human their potential regulation TNF-alpha, IL-1beta...
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to functional deficiency fragile mental retardation protein (FMRP), an RNA-binding involved in translational regulation many messenger RNAs, playing key roles synaptic morphology and plasticity. To date, no effective treatment for FXS available. We searched FMRP targets by HITS-CLIP during early development multiple mouse brain regions (hippocampus, cortex cerebellum) at a time when highly expressed...
Research Article| July 01, 2010 First global positioning system results in northern Myanmar: Constant and localized slip rate along the Sagaing fault Thomas Maurin; Maurin 1Equipe Géodynamique d'Echanges Recherche Industrie Enseignement, CEREGE, CNRS, UMR 6535, Aix en Provence, France Search for other works by this author on: GSW Google Scholar Frederic Masson; Masson 2Instituts de Physique du Globe, L'Ecole et Observatoire des Sciences la Terre, 7516, Strasbourg, Claude Rangin; Rangin U...
Until recently, a Dicer-class RNase III enzyme was believed to be essential for microRNA (miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this expectation and instead matures by direct cleavage of its pre-miRNA hairpin via the Slicer activity Argonaute2 (Ago2). In study, we used structure–function analysis define functional parameters Ago2-mediated miRNA biogenesis. These include (1) requirement base-pairing at most, but not all, positions within pre-mir-451...
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and best-studied monogenic autism. FXS results from functional absence fragile mental retardation protein (FMRP) leading to abnormal pruning consequently synaptic communication defects. Here we show that FMRP a substrate small ubiquitin-like modifier (SUMO) pathway in brain identify its active SUMO sites. We unravel consequences sumoylation neurons by combining molecular replacement strategy, biochemical...
Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID), autism, schizophrenia and epilepsy. It member of family proteins that highly conserved during evolution, sharing high homology with its Drosophila homolog, dCYFIP. CYFIP1 interacts the Fragile X mental retardation (FMRP, encoded by FMR1 gene), whose absence causes syndrome, translation initiation factor eIF4E. WAVE regulatory complex (WRC), thus representing link between translational...
Several snake venom secreted phospholipases A2 (sPLA2s) including OS2 exert a variety of pharmacological effects ranging from central neurotoxicity to anti-HIV activity by mechanisms that are not yet fully understood. To conclusively address the role enzymatic and map key structural elements responsible for its properties, we have prepared single point mutants at catalytic site large chimeras between OS1, homologous but nontoxic sPLA2. Most importantly, found active mutant H48Q is 500-fold...
The fragile X mental retardation protein (FMRP) is an RNA-binding involved in translational regulation of mRNAs that play key roles synaptic morphology and plasticity. functional absence FMRP causes the syndrome (FXS), most common form inherited intellectual disability monogenic cause autism. No effective treatment available for FXS. We recently identified Phosphodiesterase 2A (Pde2a) mRNA as a prominent target FMRP. PDE2A enzymatic activity increased brain Fmr1-KO mice, recognized model...
We have previously shown that secreted phospholipases A<sub>2</sub>(sPLA<sub>2</sub>) from bee and snake venoms potent anti-human immunodeficiency virus (HIV) activity (Fenard et al., 1999). These sPLA<sub>2</sub>s block HIV-1 entry into host cells through a mechanism linked to sPLA<sub>2</sub> binding cells. In this study, 12 synthetic peptides derived venom sPLA<sub>2</sub>(bvPLA<sub>2</sub>) been tested for inhibition of infection. The p3bv peptide (amino acids 21 35 bvPLA<sub>2</sub>)...
RNase III enzymes are fundamental to the biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs) in all species studied. Although alternative miRNA pathways independent Drosha or Dicer exist, each still requires one III-type enzyme. Here, we describe two strategies that marry either Z Integrator complex with slicing activity Argonaute2 generate highly functional mature miRNAs. We provide stringent validation their independence by demonstrating efficient knockout cells. These...
Abstract Interpretation of new high‐resolution seismic reflection sections reveals intraplate deformation oceanic crust in the West Somali Basin, between East Africa margin and Davie Ridge its northern extension. The takes form 1–2 km amplitude buckle folds with a 20–30 wavelength associated thrust faults. Reverse faulting is localized along corridors, about 15–30 wide that we interpret as inherited fracture zones extinct spreading center. Deformation westernmost segment started before...
Several anesthetics have been reported to suppress the transcription of a number genes, including Arc, also known as Arg3.1, an immediate early gene that plays significant role in memory consolidation. The purpose this study was explore mechanism anesthesia-mediated depression Arc and protein expression. Here, we demonstrate isoflurane or propofol anesthesia decreases hippocampal expression rats mice. Surprisingly, change secondary anesthesia-induced hypothermia. Furthermore, confirm vivo...