A5081675693- Estrogen and related hormone effects
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Bone health and osteoporosis research
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Psoriasis: Treatment and Pathogenesis
- Chemokine receptors and signaling
- Growth Hormone and Insulin-like Growth Factors
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Inflammatory Bowel Disease
- Galectins and Cancer Biology
- Protein Kinase Regulation and GTPase Signaling
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
University of Gothenburg
2016-2025
Science for Life Laboratory
2023-2025
Chalmers University of Technology
2024-2025
Sahlgrenska University Hospital
2004-2021
Unité de Nutrition Humaine
2018
Centre for Inflammation Research
2003-2015
National Academy of Medicine
2015
Karolinska Institutet
2014
Karolinska University Hospital
2014
National Institutes of Health
2014
The gut microbiota (GM) modulates the hosts metabolism and immune system. Probiotic bacteria are defined as live microorganisms which when administered in adequate amounts confer a health benefit on host can alter composition of GM. Germ-free mice have increased bone mass associated with reduced resorption indicating that GM also regulates mass. Ovariectomy (ovx) results loss altered status. purpose this study was to determine if probiotic treatment protects from ovx-induced loss. Mice were...
Summary Oestrogen treatment down‐regulates B lymphopoiesis in the bone marrow of mice. Meanwhile it up‐regulates immunoglobulin production. To understand better oestrogen action on male mice lacking receptor α (ERα; ERKO mice), ERβ (BERKO both receptors (DERKO mice) or wild‐type (wt) littermates were castrated and treated for 2·5 weeks with 30 μg/kg 17β‐oestradiol (E 2 ) vehicle oil as controls. The was examined by flow cytometry mature B‐cell function studied using an ELISPOT assay...
Galectin 3, an endogenous β-galactoside-binding lectin, plays important role in the modulation of immune responses. The finding that galectin 3 is present inflamed synovium patients with rheumatoid arthritis suggests protein associated pathogenesis this disease. We undertook study to investigate influence deficiency a murine model arthritis.Wild-type (WT) and 3-deficient (galectin 3(-/-) ) mice were subjected antigen-induced (AIA) through immunization methylated bovine serum albumin....
The bone-sparing effect of estrogen is primarily mediated via receptor-α (ERα), which stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal and AF-2 ligand binding domain. To evaluate role ERα for effects bone vivo, we analyzed mouse models lacking entire protein (ERα −/− ), (ERαAF-1 0 or (ERαAF-2 ). Estradiol (E2) treatment increased amount both trabecular cortical ovariectomized (OVX) WT mice. Neither nor responded to E2 OVX ERαAF-2 ERαAF-1...
It was recently reported that the synthetic compound estren increases bone mass without affecting reproductive organs or classic transcription. The aim of present study to further characterize in vivo and vitro effects estren. We demonstrate is a selective estrogen receptor modulator (SERM) with strong effect on thymus, moderate uterus trabecular bone, but no major fat cortical 11-month-old ovariectomized mice. mediated via receptors (ERs) because seen ER double-inactivated Furthermore, use...
Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because use ethanol is widespread, we assessed intake on propensity develop chronic Collagen type II-immunized mice were given water or containing 10% (vol/vol) its metabolite acetaldehyde. Their arthritis was assessed, as well impact leukocyte migration and activation intracellular transcription factors. Mice exposed daily this dose did not display any liver toxicity, erosive almost totally...
Programming of lymph node fibroblastic reticular cells by type I interferons is needed for effective antiviral CD8 + T cell responses.
Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice.
Flow cytometry is an important technique for characterization of immune cells, with accurate lymphocyte profiling being essential clinical diagnostics and research applications. While immediate processing blood samples ideal, long-term storage solutions are needed large-scale studies or settings without access to laboratory facilities. TransFix® a chemical stabilization solution that allows delayed analysis by preserving cell morphology surface markers. However, the impact cryopreservation...
T-helper 17 (Th17) cells are characterized by their production of interleukin-17 (IL-17) and have a role in the protection against infections certain inflammatory diseases. Humans who lack Th17 more susceptible to Staphylococcus aureus compared individuals having cells. S. is part commensal skin microflora also colonize infant gut. To investigate whether UV-killed would be capable inducing IL-17 than other bacteria, we stimulated mononuclear from adults, infants, newborns with various...
A more vigorous immune system activation is generally seen in women as compared to men. The reasons for these differences are still not understood. By investigating the immune-regulatory role of estrogens, we have previously shown that estradiol (E2) can regulate and ameliorate rheumatoid arthritis models. aim this study was elucidate ovariectomy (ovx) innate responses.Female mice were ovx or sham operated. After three weeks, either dorsal air pouches established by injections sterile with...
Cholinergic pathways of the autonomic nervous system are known to modulate inflammation. Because atherosclerosis is a chronic inflammatory condition, we tested whether cholinergic signaling operates in this disease. We have analyzed expression α7 nicotinic acetylcholine receptor (α7nAChR) human atherosclerotic plaques and studied its effects on development hypercholesterolemic Ldlr(-/-) mouse model.α7nAChR protein was detected T cells macrophages surgical specimens plaques. To study role...
Summary Oestrogen has a dichotomous effect on the immune system. T and B lymphopoiesis in thymus bone marrow is suppressed, whereas antibody production stimulated by oestrogen. In this study importance of oestrogen receptors (ER) ER‐α ER‐β aged system was investigated 18 months old‐wild type (WT), (ERKO), (BERKO) double (DERKO) knock‐out mice, compared with 4 old WT mice. Cell phenotypes marrow, spleen thymus, frequency immunoglobulin (Ig) spot forming cells (SFC) were determined. We show...
Abstract Generalized osteoporosis in postmenopausal rheumatoid arthritis (RA) is caused both by estrogen deficiency and the inflammatory disease. The relative importance of each these factors unknown. aim this study was to establish a murine model RA, evaluate mechanisms menopause arthritis-related osteoporosis. To mimic DBA/1 mice were ovariectomized, followed induction type II collagen-induced arthritis. After had been killed, paws collected for histology, one femur bone mineral density...
Lasofoxifene (las) and bazedoxifene (bza) are third generation selective estrogen receptor modulators (SERMs) with minimal estrogenic side effects, approved for treatment of postmenopausal osteoporosis. T cells involved in the pathology osteoporosis previous studies have established an important role 17β-estradiol (E2) cell development function. E2 causes a drastic thymic atrophy, alters composition populations, inhibits dependent inflammation. In contrast, second SERM raloxifene (ral) lacks...
Estrogen (E2) delays onset and decreases severity of experimental arthritis. The aim this study was to investigate the importance total estrogen receptor alpha (ERα) expression cartilage-specific ERα in genetically modified mice for ameliorating effect treatment Mice with (total ERα-/-) or (Col2α1-ERα-/-) inactivation wild-type (WT) littermates were ovariectomized, treated E2 placebo, induced antigen-induced arthritis (AIA). At termination, knees collected histology, synovial splenic cells...
The third generation selective estrogen receptor modulators lasofoxifene (las) and bazedoxifene (bza) are indicated for treatment of postmenopausal osteoporosis. 17β-Estradiol (E2) the second SERM raloxifene (ral) have major effects on immune system, particularly B cells. Treatment with E2 or ral inhibits lymphopoiesis E2, but not ral, stimulates antibody production. las bza system been studied. Therefore, aim this study was to investigate their role in cell development, maturation,...
Women show an increased prevalence of adult-onset asthma compared to men and previous studies have shown that testosterone inhibits while estrogen worsens allergen-induced airway inflammation. However, detailed knowledge about the aggravating effects on immune responses remain unclear. Defining physiological levels in would aid development improved treatment strategies. In this study, importance for sex difference was determined using a murine model house dust mite (HDM)-induced inflammation...
Although sex and gender are recognized as major determinants of health immunity, their role is rarely considered in clinical practice public health. We identified six bottlenecks preventing the inclusion considerations from basic science to practice, precision medicine policies. (i) A terminology-related bottleneck, linked definitions themselves, lack consensus on how evaluate gender. (ii) data-related due gaps sex-disaggregated data, data trans/non-binary people identity. (iii)...
Abstract Objective In postmenopausal rheumatoid arthritis (RA), both estrogen deficiency and the inflammatory disease contribute to development of generalized osteoporosis. Hormone replacement therapy (HRT) with estradiol preserves bone mineral density (BMD) ameliorates arthritis, but long‐term is no longer an option due significant side effects. We therefore used a mouse model human RA test hypothesis that selective receptor modulator (SERM), raloxifene analog LY117018, could be beneficial...
Objective. RA predominantly affects post-menopausal women and is strongly associated with development of generalised osteoporosis. To find treatments that target both joint manifestations osteoporosis in desirable. The third generation selective oestrogen receptor modulators (SERMs) [lasofoxifene (LAS) bazedoxifene (BZA)] are new treatment options for aim this study was to investigate the effects LAS BZA on arthritic disease inflammation-associated bone loss using CIA mice. Methods. Female...