A5051870583- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- ATP Synthase and ATPases Research
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Cardiovascular and exercise physiology
- Proteoglycans and glycosaminoglycans research
- Protease and Inhibitor Mechanisms
- Mast cells and histamine
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Sirtuins and Resveratrol in Medicine
- Bone Tissue Engineering Materials
- Spaceflight effects on biology
- Lipid metabolism and disorders
- Kruppel-like factors research
- Muscle Physiology and Disorders
- Systemic Sclerosis and Related Diseases
- Fibroblast Growth Factor Research
- Renin-Angiotensin System Studies
- Ovarian cancer diagnosis and treatment
- Cardiovascular Syncope and Autonomic Disorders
Inje University
2014-2024
De La Salle University
2024
Taipei Veterans General Hospital
2004
University Hospital of Heraklion
2004
University College London
2004
Royal National Orthopaedic Hospital
2004
Hospital Universitario Puerta de Hierro Majadahonda
2004
Royal London Hospital
2004
Tri-Service General Hospital
2004
Inonu University
2004
Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and cardio protective effect against ischemia reperfusion injury. In this study, we ascertained whether Ech enhances the mitochondrial biogenesis oxidative phosphorylation in rat myoblast H9c2 cells. To study effects of on biogenesis, measured mass, level phosphorylation, regulatory gene expression. treatment did not induce cytotoxicity. However, enhanced oxygen consumption rate...
Recent trends suggest novel natural compounds as promising treatments for cardiovascular disease. The authors examined how neopetroside A, a pyridine nucleoside containing an α-glycoside bond, regulates mitochondrial metabolism and heart function investigated its cardioprotective role against ischemia/reperfusion injury. Neopetroside A treatment maintained cardiac hemodynamic status respiration capacity significantly prevented fibrosis in murine models. These effects can be attributed to...
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro vivo models have been demonstrated, action this compound mitochondrial oxidative phosphorylation system remains unclear. Here we verify role protecting capacity during hypoxia-reoxygenation (HR). Necrox-5 treatment (10 µM) non-treatment were employed isolated rat hearts hypoxia/reoxygenation using an ex Langendorff system. Proteomic analysis was performed liquid chromatography-mass spectrometry (LC-MS)...
Abstract Aims Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that was reported to target ion channel proteins. L-type voltage-dependent Ca2+ (LTCC) density and dysfunction critical player in heart failure with reduced ejection fraction (HFrEF). However, underlying cellular mechanisms by which CRBN regulates LTCC subtype Cav1.2α during cardiac remain unclear. Here, we explored role HFrEF investigating direct regulatory activity examining how it can serve as address...
Ischemic cardiomyopathy (ICM) is the leading cause of heart failure. Proteomic and genomic studies have demonstrated ischemic preconditioning (IPC) can assert cardioprotection against ICM through mitochondrial function regulation. Considering IPC conducted in a relatively brief period, regulation protein expression also occurs very rapidly, highlighting importance modulation by post-translational modifications. This study aimed to identify analyze novel phosphorylated proteins that be...
Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation the BG receptor induces an increase in intracellular Ca2+, which may induce exocytosis. However, little is known about precise mechanisms underlying activation possible role mitochondria this process. The present study examined whether induced mast cell degranulation, evaluated calcium transients during activation. Our investigation...