A5101397203- Cancer, Hypoxia, and Metabolism
- Axon Guidance and Neuronal Signaling
- Medicinal Plant Pharmacodynamics Research
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Apelin-related biomedical research
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
- Mechanical Circulatory Support Devices
- Pericarditis and Cardiac Tamponade
- Neurogenesis and neuroplasticity mechanisms
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Analysis
- Liver Diseases and Immunity
- Cardiac Arrhythmias and Treatments
- Chemical Thermodynamics and Molecular Structure
- Chemokine receptors and signaling
- Neurosurgical Procedures and Complications
- Adsorption, diffusion, and thermodynamic properties of materials
- S100 Proteins and Annexins
- Additive Manufacturing Materials and Processes
- Adenosine and Purinergic Signaling
- Sepsis Diagnosis and Treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
Sir Run Run Shaw Hospital
2021-2024
Zhejiang University
2021-2024
Henan University of Science and Technology
2024
The University of Texas Health Science Center at Houston
2019-2024
Palo Alto University
2024
Stanford University
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Stanford Medicine
2023
Southwest University
2020-2022
Cyclin D1 is a multifaceted regulator of both transcription and cell-cycle progression that exists in two distinct isoforms, cyclin D1a D1b. In the prostate, acts through discrete mechanisms to negatively regulate androgen receptor (AR) activity thus limit androgen-dependent proliferation. Accordingly, rarely overexpressed prostatic adenocarcinoma holds little prognostic value this tumor type. However, common polymorphism (A870) known facilitate production D1b associated with increased...
Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition therapeutic development. Neutrophil influx is a hallmark of ARDS associated with the release tissue-destructive immune effectors, such as matrix metalloproteinases (MMPs) membrane-anchored metalloproteinase disintegrins (ADAMs). Here, we observed using intravital microscopy that Adam8-/- mice had impaired neutrophil transmigration. In mouse pneumonia...
Previous studies implicated the neuronal guidance molecule netrin-1 in attenuating myocardial ischemia-reperfusion injury. However, tissue-specific sources and receptor signaling events remain elusive. Neutrophils are among first cells responding to an ischemic insult can be associated with tissue injury or rescue. We found levels were elevated blood of patients infarction, as well mice exposed ischemia-reperfusion. Selectively increased infarct sizes troponin Ntn1loxP/loxP Lyz2 Cre+ mice,...
Abstract Acute myocardial infarction stands as a prominent cause of morbidity and mortality worldwide 1-6 . Clinical studies have demonstrated that the severity cardiac injury following exhibits circadian pattern, with larger infarct sizes poorer outcomes in patients experiencing morning onset infarctions 7-14 However, molecular mechanisms govern variations remain unclear. Here, we show BMAL1 14-20 , core transcription factor, orchestrates diurnal variability injury. Unexpectedly, modulates...
Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This is terminated by its uptake into cells equilibrative nucleoside transporters (ENTs). Thus, we hypothesized that targeting ENTs would function to increase cardiac concomitant cardioprotection against IRI. Mice were exposed injury. Myocardial was attenuated mice treated with the nonspecific ENT inhibitor dipyridamole. A comparison of global Ent1 or Ent2 deletion...
During myocardial ischemia, hypoxia-inducible factors are stabilized and provide protection from ischemia reperfusion injury. Recent studies show that myocyte-specific factor 2A promotes tolerance through induction of epidermal growth factor, amphiregulin. Here, the authors hypothesized may enhance receptor 1 (ERBB1) expression in myocardium could interface between its effect on providing to injury.Human tissues were obtained ischemic heart disease patients normal control compare ERBB1...
Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family, plays diverse roles in tumorigenesis, metastasis, and prognosis various human tumors. However, no pan-cancer analysis has been conducted to illustrate its distinctive effects on clinical via underlying mechanisms biological characteristics.Herein, we exploited existed public bioinformatics database, primarily TCGA database GTEx data, comprehensively analyze value CCL5 involved patient prognosis.This study found that was...
The transcription factor hypoxia-inducible HIF1A induces cardioprotection from ischemia and reperfusion injury. Here, we investigate tissue-specific pathways that are critical for HIF1A-elicited tissue protection. Initial studies showed mice with induced global Hif1a deletion (Hif1aloxP/loxP UbiquitinCre+) have exaggerated myocardial injury during in situ reperfusion. Surprisingly, this phenotype was mirrored only myeloid-specific (Hif1a loxP/loxP LysM Cre+). In contrast, specific Myosin...
Abstract Sepsis and sepsis‐associated lung inflammation significantly contribute to the morbidity mortality of critical illness. Here, we examined hypothesis that neuronal guidance proteins could orchestrate inflammatory events during endotoxin‐induced injury. Through a targeted array, identified netrin‐1 as top upregulated protein in macrophages treated with lipopolysaccharide (LPS). Furthermore, found is highly enriched infiltrating myeloid cells, particularly LPS‐induced Transcriptional...
Abstract Previous studies have shown that individuals with a history of childhood emotional neglect show impaired empathy. However, accurately identifying emotions in others is an essential aspect empathic functioning. The current study aimed to investigate the influence on accuracy. A total 92 participants were recruited from local university. Forty‐six randomly assigned social exclusion context (SE), and other 46 inclusion (SI). Childhood Trauma Questionnaire was used measure neglect....
A method for the determination of C1-C6 organic acids in products from syngas to olefins (SGTO) was developed by ion chromatography, which included optimized separation conditions, linear ranges and working curves determined using standard samples, precision accuracy alkaline-washing conditions pretreatment oil phase samples. The SGTO water samples were analyzed according method. linearity test showed that correlation coefficients (R2) all specific concentration above 0.99, means components...
Abstract With the rapid growth of transportation, all kinds traffic data show explosive growth, and accurate timely forecasting is also particularly important. Among them, flow prediction basis for realizing reasonable guidance control, it a prerequisite intelligent transportation. Traffic belongs to typical chaotic time series with strong non-linearity. In application neural network, two-layer network can theoretically approach any continuous function infinitely, so as achieve very...
Background: After heart transplantation, endomyocardial biopsy is used to monitor for acute rejection (AR). However, invasive, and its conventional histological interpretation has limitations. Extracellular vesicles (EVs) are lipid bilayer secreted by various cell types into the circulation. EVs express an array of biomolecules indicative their parent cells act as cargo capable delivering nucleic acids, proteins, organelles. Here, we investigated whether AR affects surface markers...
Introduction: Beta blockers, renin-angiotensin-aldosterone antagonists, and mineralocorticoid antagonists are mainstays of current guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction. They have been shown to reduce morbidity mortality patients, reverse remodeling, improve left ventricular fraction (LVEF) landmark human clinical trials. GDMT has hypothesized interact protective effects bioenergetics cardiac injury by reducing workload energy demand. We...
Journal Article A rare aortic pseudoaneurysm-right atrial fistula Get access Yankai Mao, Mao Department of Diagnostic Ultrasound & Echocardiography, Sir Run Shaw Hospital, Zhejiang University School Medicine, East Qingchun Road 3, Hangzhou 310016, China Corresponding author. Tel: +86(0571)13750898404, Email: [email protected] https://orcid.org/0000-0003-4412-6329 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jiwen Li, Li Cardiac Surgery,...
Abstract Recent studies suggest that reward anticipation decreases individuals’ acute stress responses. However, individuals who have experienced early life (ELS) may a blunted capacity for anticipation, which reduces its buffering effect on psychosocial To investigate this phenomenon, 66 young adults completed the Trier Social Stress Test following task, and their ELS levels were measured using Childhood Trauma Questionnaire (CTQ). Meanwhile, current study collected biological psychological...
A 65-years-old female presents to the emergency room after C2 dorsal root ganglion nerve block for cervicogenic headaches, where intraoperatively she became hypotensive and unresponsive with sinus tachycardia 140s. She required brief intubation intravenous vasopressors resuscitation was quickly extubated complete neurologic recovery within hours of presentation. Her vital signs were normal limits. had no clinical heart failure on exam. Laboratory values limits except elevated hs- troponin...