Wei Ruan

ORCID: 0000-0002-2718-7923
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Research Areas
  • Ferroelectric and Piezoelectric Materials
  • Microwave Dielectric Ceramics Synthesis
  • Acoustic Wave Resonator Technologies
  • Photorefractive and Nonlinear Optics
  • Microwave Engineering and Waveguides
  • Cancer, Hypoxia, and Metabolism
  • Multiferroics and related materials
  • Antenna Design and Analysis
  • Advanced Antenna and Metasurface Technologies
  • Electromagnetic Compatibility and Noise Suppression
  • Adenosine and Purinergic Signaling
  • MicroRNA in disease regulation
  • Axon Guidance and Neuronal Signaling
  • Antenna Design and Optimization
  • Asphalt Pavement Performance Evaluation
  • Cardiac Ischemia and Reperfusion
  • Geological Modeling and Analysis
  • Metamaterials and Metasurfaces Applications
  • Mitochondrial Function and Pathology
  • Anesthesia and Neurotoxicity Research
  • Ziziphus Jujuba Studies and Applications
  • ZnO doping and properties
  • Orthopaedic implants and arthroplasty
  • Cancer-related molecular mechanisms research
  • Titanium Alloys Microstructure and Properties

Chinese Academy of Sciences
2003-2025

Institute of Semiconductors
2025

Shanghai Institute of Ceramics
2010-2024

Hebei University of Science and Technology
2022-2024

The University of Texas Health Science Center at Houston
2021-2024

Second Xiangya Hospital of Central South University
2015-2024

Central South University
2015-2024

University of Chinese Academy of Sciences
2013-2024

Aerospace Information Research Institute
2024

Fudan University
2023

Highly transparent ceramics of La‐doped 0.75Pb(Mg 1/3 Nb 2/3 )O 3 –0.25PbTiO were fabricated by a two‐stage sintering method from conventional raw materials. The exhibited transparency as high 65% for the infrared wavelength. Large quadratic electro‐optic coefficient 66 × 10 −16 (m/v) 2 was obtained, which highest value reported so far in Pb(Mg –PbTiO ceramics. ferroelectric phase inducing threshold electric field E th and domain structure studied.

10.1111/j.1551-2916.2010.03675.x article EN Journal of the American Ceramic Society 2010-03-05

AimsEndothelial cell injury induced by inflammatory factors plays a critical role in the pathogenesis of numerous vascular diseases. MicroRNAs are well known to be implicated proliferation and apoptosis responses; however, it remains determined whether microRNAs associated with tumour necrosis factor (TNF)-α-mediated endothelial injury. The aim present study was investigate TNF-α-induced apoptosis.

10.1093/cvr/cvr290 article EN Cardiovascular Research 2011-10-28

Sepsis‐induced cardiac dysfunction remains one of the major causes death in intensive care units. Overwhelmed inflammatory response and unrestrained cell play critical roles sepsis‐induced dysfunction. Peroxisome proliferator‐activated receptor‐ (PPAR‐) γ has been proven to be cardioprotective sepsis. However, mechanism PPAR‐ ‐mediated cardioprotection its relationship with inflammation are unclear. We hypothesized that activation by reducing inflammation, myocardial apoptosis, necroptosis...

10.1155/2017/8326749 article EN cc-by Oxidative Medicine and Cellular Longevity 2017-01-01

Previous studies implicated the neuronal guidance molecule netrin-1 in attenuating myocardial ischemia-reperfusion injury. However, tissue-specific sources and receptor signaling events remain elusive. Neutrophils are among first cells responding to an ischemic insult can be associated with tissue injury or rescue. We found levels were elevated blood of patients infarction, as well mice exposed ischemia-reperfusion. Selectively increased infarct sizes troponin Ntn1loxP/loxP Lyz2 Cre+ mice,...

10.1084/jem.20210008 article EN cc-by-nc-sa The Journal of Experimental Medicine 2021-04-23

Abstract Acute myocardial infarction stands as a prominent cause of morbidity and mortality worldwide 1-6 . Clinical studies have demonstrated that the severity cardiac injury following exhibits circadian pattern, with larger infarct sizes poorer outcomes in patients experiencing morning onset infarctions 7-14 However, molecular mechanisms govern variations remain unclear. Here, we show BMAL1 14-20 , core transcription factor, orchestrates diurnal variability injury. Unexpectedly, modulates...

10.21203/rs.3.rs-3938716/v1 preprint EN cc-by Research Square (Research Square) 2024-02-28

For RSSI measurement of RF systems, a wide band, large dynamic range (DR), parallel-summation logarithmic amplifier is presented in this paper. The circuit adopts an 8-stage DC-coupled cascaded limiting structure. output voltage the converted into current through rectifier to realize parallel summation. In order reduce offset, paper introduces offset reduction circuits gain and stage, respectively. addition, log slope adjuster proposed, which can achieve control different frequency inputs....

10.3390/electronics14050958 article EN Electronics 2025-02-27

Transparent ceramics of La-doped Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) x/75/25 are prepared, and the ferroelectric domains, dielectric, properties investigated. A double hysteresis loop small fingerprint domains with uniform distribution observed for 3/75/25 indicate an intermediate state. The dielectric behavior under dc bias evolution increasing electric field field-induced phase transition, it is proposed that unstable state which would experience obvious transition origin giant electro-optic...

10.1063/1.3646553 article EN Journal of Applied Physics 2011-10-01

The microstructure, mechanical properties, and in vitro biocompatibility of vacuum-sintered Ti-xZr binary alloys (x = 5, 15, 25, 35, 45 wt%) were investigated. results indicated that α α' phase existed alloys. hardness the Ti-Zr increased as contents ranged from 473 HV (Ti-5Zr) to 525 (Ti-45Zr). Increasing Zr content could lead an increase compressive bending strength. Additionally, Ti-45Zr alloy exhibited maximum strength 867.1 MPa 1599.8 which much larger than CP-Ti. Moreover, all showed a...

10.1177/0885328218811052 article EN Journal of Biomaterials Applications 2018-11-05

Jujube pulp separated from Ziziphus jujube is often discarded after processing, resulting in a serious waste of resources and environmental pollution. Herein, was used as raw material for vinegar fermentation. To investigate the dynamic distribution microorganisms flavor substances ZJV, correlations between variables (e.g., total acid, reducing sugar, temperature) (organic acids, amino volatile substances) were analyzed. Physicochemical indicators (temperature, alcohol) main factors...

10.3390/foods11213334 article EN cc-by Foods 2022-10-24

Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This is terminated by its uptake into cells equilibrative nucleoside transporters (ENTs). Thus, we hypothesized that targeting ENTs would function to increase cardiac concomitant cardioprotection against IRI. Mice were exposed injury. Myocardial was attenuated mice treated with the nonspecific ENT inhibitor dipyridamole. A comparison of global Ent1 or Ent2 deletion...

10.1172/jci.insight.166011 article EN cc-by JCI Insight 2023-06-07

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as spin liquid and unconventional superconductivity. The dominance is conventionally attributed lack of electron screening in third dimension. Here, we discover an intriguing metal Mott insulator transition 1T-TaSe

10.1093/nsr/nwad144 article EN cc-by National Science Review 2023-05-16

Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark bowel diseases. We hypothesize that HIF could be stabilized in CD4+ T cells during intestinal inflammation alter the functional responses via regulation microRNAs. Our assays reveal markedly increased cell-intrinsic protein experimental colitis. microRNA screen primary points us towards miR-29a our subsequent studies identify selective role for HIF-2α...

10.1038/s41467-024-52113-y article EN cc-by-nc-nd Nature Communications 2024-09-13

Endothelial dysfunction induced by oxidative stress and inflammation plays a critical role in the pathogenesis of cardiovascular diseases. The anesthetic sevoflurane confers cytoprotective effects through its anti-inflammatory properties various pathologies such as systemic inflammatory response syndrome ischemic-reperfusion injury but mechanism is unclear. We hypothesized that can protect against tumor necrosis factor (TNF)-α-induced endothelial promoting production endothelium-dependent...

10.1016/j.bbrc.2015.03.126 article EN cc-by-nc-nd Biochemical and Biophysical Research Communications 2015-04-05

Septic myocardial dysfunction remains prevalent and raises mortality rate in patients with sepsis. During sepsis, tissues undergo tremendous oxidative stress which contributes critically to organ dysfunction. Edaravone, a potent radical scavenger, has been proved beneficial ischemic injuries involving hypoxia-inducible factor- (HIF-) 1, key regulator of prominent antioxidative protein heme oxygenase- (HO-) 1. However, its effect septic unclarified. We hypothesized that edaravone may prevent...

10.1155/2018/5216383 article EN cc-by Oxidative Medicine and Cellular Longevity 2018-01-01
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