A5038910297- Cancer Immunotherapy and Biomarkers
- Spinal Hematomas and Complications
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Case Reports on Hematomas
- Spine and Intervertebral Disc Pathology
- COVID-19 and healthcare impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Endometrial and Cervical Cancer Treatments
- Effects of Radiation Exposure
- Connective tissue disorders research
- Neurological and metabolic disorders
- Acute Myeloid Leukemia Research
- Nausea and vomiting management
- Acute Ischemic Stroke Management
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Liver physiology and pathology
Kobe University Hospital
2021-2024
Kobe University
2020
Japanese Red Cross Kumamoto Hospital
2017
University of Tsukuba
2002
An important unmet need for new treatment options remains patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC) previously treated both platinum-based chemotherapy anti-programmed death protein 1 (PD-1) antibody. Retrospective studies suggest that previous immune checkpoint inhibitor might augment the efficacy of subsequent chemotherapy. Here, we conducted a phase II trial aimed to evaluate safety paclitaxel plus biweekly cetuximab in this setting.
6092 Background: Salivary gland cancer is rare and has various pathological subtypes. With this rarity heterogeneity, the therapeutic contribution of chemotherapy, including immune checkpoint inhibitors, for recurrent or metastatic salivary (RM-SGC) not been elucidated. The purpose trial was to investigate efficacy safety nivolumab patients with platinum-refractory RM-SGC. Methods: This open-label, single-arm, multicenter phase II conducted at 9 centers in Japan. Eligible had measurable...
We present a case of thoracic schwannoma with an intravertebral component, so-called "dumbbell-type" tumor, that was resected combined minimally invasive approach using microsurgery and thoracoscopic surgery simultaneously. A 31-year-old man admitted to our hospital for treatment 45 mm in maximal diameter at the level third vertebra. After tumor separated from structures by microsurgical technique via posterior hemilaminectomy minimal unilateral facetectomy, mass removed completely video...
Although nivolumab is administered every two or four weeks, high programmed cell death-1 (PD-1) binding of on T cells lasting for several months has been reported. A relationship between the PD-1 occupancy rate T-cells and efficacy not yet fully understood. The present study used flow cytometric analyses to determine time-dependence in five patients who discontinued nivolumab. at relapse re-challenge was also studied. Occupancies after discontinuation were measured a total 32 points. data...
6032 Background: An important unmet need in treatment options remains for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC) previously treated both platinum-based chemotherapy anti-PD-1 antibody (PD-1 Ab). Recent retrospective studies suggest that previous Immune checkpoint inhibitor might augment the efficacy of subsequent chemotherapy. This phase II trial aimed to evaluate safety paclitaxel plus biweekly cetuximab (PTX+bwCmab) R/M-HNSCC platinum PD-1...
Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm. We report patient with HS treated induction chemotherapy followed by curative surgery. A 50-year-old man was referred to our hospital because of retroperitoneal tumor. computed tomography scan revealed bulky mass, infiltrating the surrounding organ. An excisional biopsy confirmed diagnosis HS. The tumor shrunk after multidrug chemotherapy. However, positron emission showed uptake fludeoxyglucose in residual He underwent right...
Abstract Background Although COVID-19 severity in cancer patients is high, the safety and immunogenicity of BNT162b2 mRNA vaccine undergoing chemotherapy for solid cancers Japan have not been reported. Methods We investigated 41 healthy volunteers who received 2 doses BNT162b2. evaluated serum IgG antibody titers S1 protein by ELISA at pre-vaccination, prior to second dose 14 days after vaccination 24 cytotoxic (CC group), 17 immune checkpoint inhibitor therapy (ICI group) 12 age-matched (HV...
Acute myelogenous leukemia (AML) with t (16;21) (p11;q22) is a rare subtype relatively high incidence in young individuals and poor prognosis. This chromosomal rearrangement results FUS-ERG fusion transcripts. We describe patient AML who underwent successful monitoring for transcripts by real-time quantitative polymerase chain reaction (RT-qPCR). designed DNA primers based on the leukemic cells of this monitored minimal residual disease RT-qPCR. Standard multiagent chemotherapy could not...