A5101938947- Tryptophan and brain disorders
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Gut microbiota and health
- Diet and metabolism studies
- Wnt/β-catenin signaling in development and cancer
- Muscle activation and electromyography studies
- Reproductive System and Pregnancy
- Muscle Physiology and Disorders
- Renal and related cancers
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Platelet Disorders and Treatments
- Nerve injury and regeneration
- Glycosylation and Glycoproteins Research
- Autoimmune Bullous Skin Diseases
- Fibroblast Growth Factor Research
- Bioinformatics and Genomic Networks
- Contact Dermatitis and Allergies
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Second Affiliated Hospital of Zhejiang University
2022
Zhejiang University
2019-2022
Zhejiang University-University of Edinburgh Institute
2022
First Affiliated Hospital Zhejiang University
2022
Academy of Military Medical Sciences
2020
People's Liberation Army 401 Hospital
2020
China Medical University
2018
Shanghai Jiao Tong University
2014
Stem cell-based tissue regeneration strategies are promising treatments for severe endometrial injuries. However, there few appropriate seed cells regenerating a full-thickness endometrium, which mainly consists of epithelia and stroma. Müllerian ducts in female embryonic development develop into Hence, we first generated human pluripotent stem (hPSC)-derived duct-like (MDLCs) using defined effective protocol. The MDLCs bi-potent, can gradually differentiate epithelial stromal cells,...
Characterized by their slow adhering property, skeletal muscle myogenic progenitor cells (MPCs) have been widely utilized in tissue engineering for regeneration, but with limited efficacy. Skeletal regeneration is regulated various cell types, including a large number of rapidly (RACs) where functions and mechanisms are still unclear. In this study, we explored the function RACs co-culturing them MPCs biomimetic organoid system. Results showed that promoted potential organoid. Single-cell...
Abstract Heparanase (HPSE) is an endo-β-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release cytokines are immobilized by binding proteoglycans (HSPGs), consequently activating signaling pathways. This function HPSE correlated its expression level normally very low majority tissues. Exceptionally, human platelets express high HPSE, suggesting a unique physiological role this cell. Using K562 cell line, we found...
Abstract We report a 21‐year‐old man with recurrent bullous eruptions and severe itching on the lower legs feet since 5 years of age. Dry, dirty brown, tile‐like scales covered his dystrophic toenails. Nodular prurigo‐like lesions, scarring papules milia remitted after eruptions. His father another two family members had similar but mild presentations bullae legs. Whole exome sequencing detected heterozygous variants COL 7A1 c.6698G>A FLG c.7249C>T in this pedigree. was reported...
Although aging is an increasingly severe healthy, economic, and social global problem, it far from well-modeling due to the process's complexity. To promote modeling, here we did quantitative measurement based on blood transcriptome. Specifically, transcriptome landscape was constructed through ensemble modeling in a cohort of 505 people, 1138 age-related genes were identified. assess rate linear dimension aging, simplified clock, which distinguished fast-aging slow-aging populations showed...
The objective of this study was to investigate the antioxidant capability and preventive effect probiotics on high fat diet induced oxidative damage. Thirty male rats were randomly divided into three groups.The control group consumed a normal standard (5% fat, w:w), received (20% supplemented with 2% probiotics. After 6 weeks, liver determined DNA fragmentation cell using comet assay. results showed that could induce stress, shown as significant increases in lipid peroxidation nitric oxide...
Abstract Although aging is an increasingly severe healthy, economic, and social global problem, it far from well-modeling due to the process’s complexity. To promote modeling, here we did quantitative measurement based on blood transcriptome. Specifically, transcriptome landscape was constructed through ensemble modeling in a cohort of 505 people, 1138 age-related genes were identified. assess rate linear dimension aging, simplified clock, which distinguished fast-aging slow-aging...