Alireza Afshar

ORCID: 0000-0002-8618-5872
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Research Areas
  • Extracellular vesicles in disease
  • Urological Disorders and Treatments
  • Sperm and Testicular Function
  • MicroRNA in disease regulation
  • Tissue Engineering and Regenerative Medicine
  • Seaweed-derived Bioactive Compounds
  • Marine Invertebrate Physiology and Ecology
  • Birth, Development, and Health
  • Diet and metabolism studies
  • Marine Sponges and Natural Products
  • Organ Transplantation Techniques and Outcomes
  • RNA Interference and Gene Delivery
  • Echinoderm biology and ecology
  • Wound Healing and Treatments
  • Gut microbiota and health
  • Advanced Fluorescence Microscopy Techniques
  • Urologic and reproductive health conditions
  • Biological Research and Disease Studies
  • Reproductive Biology and Fertility
  • Corneal Surgery and Treatments
  • Bone Tumor Diagnosis and Treatments
  • Animal Nutrition and Physiology
  • Health Policy Implementation Science
  • Electrospun Nanofibers in Biomedical Applications
  • Advanced Electron Microscopy Techniques and Applications

West Kazakhstan Marat Ospanov State Medical University
2023-2025

Bushehr University of Medical Sciences
2020-2024

Biotechnology Research Center
2020-2024

Shiraz University
2023

UNSW Sydney
2023

Gulf Research Center
2022

Tehran University of Medical Sciences
2021

Iranshahr University
2021

Persian Gulf University
2020

Nowadays, major attention is being paid to curing different types of cancers and focused on natural resources, including oceans marine environments. Jellyfish are animals with the ability utilize their venom in order both feed defend. Prior studies have displayed anticancer capabilities various jellyfish. Hence, we examined features Cassiopea andromeda Catostylus mosaicus an vitro situation against human pulmonary adenocarcinoma (A549) cancer cell line. The MTT assay demonstrated that...

10.3390/md21030168 article EN cc-by Marine Drugs 2023-03-07

Marine invertebrates are multicellular organisms consisting of a wide range marine environmental species. Unlike vertebrates, including humans, one the challenges in identifying and tracking invertebrate stem cells is lack specific marker. Labeling with magnetic particles provides non-invasive, vivo method using MRI. This study suggests antibody-conjugated iron nanoparticles (NPs), which detectable MRI for tracking, to detect cell proliferation Oct4 receptor as marker cells. In first phase,...

10.3390/bios13020268 article EN cc-by Biosensors 2023-02-13

Regenerative effects of sea anemone-derived exosomes on human foreskin fibroblasts (HFFs) were investigated. Water-based extracts from regenerating Aulactinia stella tissue collected at various time points, and extracted after inducing wounds. Both the extract tested HFF for proliferation in vitro wound healing. In silico analysis explored protein–protein docking between regenerative exosome proteins receptors. The MTT (3-(4,5-dimethylthiazol-2yl)-2,5 diphenyltetrazolium bromide assay...

10.1080/14786419.2024.2352144 article EN Natural Product Research 2024-06-02

Sea cucumber extracts and their bioactive compounds have the potential for stem cell proliferation induction beneficial therapeutic properties. In this study, human umbilical cord mesenchymal stromal/stem cells (hUC-MSCs) were exposed to an aqueous extract of Holothuria parva body walls. Proliferative molecules detected using gas chromatography-mass spectrometry (GC-MS) analysis in H. parva. The concentrations 5, 10, 20, 40, 80 µg/mL 10 20 ng/mL epidermal growth factor (EGF) as positive...

10.3390/md21050267 article EN cc-by Marine Drugs 2023-04-26

This study set out to evaluate the wound healing properties of brittle star extracts in vitro and vivo. Due great arm regeneration potential star, Ophiocoma cynthiae, present aimed effect hydroalcoholic undergoing models. The samples were collected from Nayband Bay, Bushehr, Iran. After induction stars, relating different times prepared. GC-MS analysis, MTT cell viability migration, Western blot, computational analysis tests performed. Based on findings, two BSEs chosen for vivo testing....

10.3390/md21070381 article EN cc-by Marine Drugs 2023-06-28

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and rapidly spread worldwide.Since then, scientists have searched to find an effective treatment for disease .In this regard, several antiviral drugs are currently undergoing clinical trial studies evaluate their safety efficacy the of COVID-19.Some these been designed based on fact that SARS-CoV-2 is a positive-sense single-stranded RNA virus previous showed anti-RNA virus, single strand inhibiting...

10.30699/mmlj17.4.1.11 article EN Modern Medical Laboratory Journal 2021-01-01

Abstract Background One of the main cause male infertility is non-obstructive azoospermia, which not manageable medically. The first aim current research was to show effect extracellular vesicle-contained conditioned media (CM) instead mesenchymal stromal/stem cells (MSCs) for treatment azoospermia. In next step, we aimed study differentiation potential MSCs into spermatocytes after injection in mice seminiferous tubules. This has provided an applied busulfan-induced azoospermia using...

10.21203/rs.3.rs-169243/v2 preprint EN cc-by Research Square (Research Square) 2022-02-04

Background: Mandible bone cancer, while relatively rare, poses significant challenges due to its aggressive nature and the complex treatment required. This bibliometric review aims analyze trends patterns in mandible cancer research from 1933 2024, providing insights into evolution of scholarly contributions impact various studies this field. Materials Methods: Data were collected Web Science Core Collection Scopus databases, focusing on articles published between 2024. A total 8,093...

10.31661/gmj.v13isp1.3541 article EN Galen Medical Journal 2024-12-31

Male infertility affects a significant portion of the global population, contributing to nearly half all cases. Common underlying causes include disruptions in spermatogenesis, hormonal imbalances, and genetic anomalies. Traditional treatments, such as hormone therapy, surgical interventions, assisted reproductive technologies, often exhibit limited efficacy due their invasive nature, systemic side effects, high financial costs. This study explores nanomedicine’s potential targeted approach...

10.18502/jirb.v12i4.17976 article EN Journal of Infertility and Reproductive Biology 2024-12-20

We investigated the effect of Persian Gulf algae derivatives, namely phycocyanin (PC) and fucoidan (FUC), on performance, reproductive traits, immune responses laying Japanese quails. A completely randomized design was used to distribute 250 six-wk-old quails with an average body weight 215 ± 10 g into 5 treatments, replicates, birds in each replicate over a 5-wk period. Unlike control groups, treatment groups received drinking water supplemented PC FUC at concentrations 20 or 40 mg/L,...

10.1016/j.psj.2023.103295 article EN cc-by Poultry Science 2023-11-17

Abstract One of the main cause male infertility is non-obstructive azoospermia, which not manageable medically. The first aim current research was to show effect extracellular vesicle-contained conditioned media (CM) instead mesenchymal stromal/stem cells (MSCs) for treatment azoospermia. In next step, we aimed study differentiation potential MSCs into spermatocytes after injection in mice seminiferous tubules. This has provided an applied busulfan-induced azoospermia using adipose...

10.21203/rs.3.rs-169243/v1 preprint EN cc-by Research Square (Research Square) 2021-03-01

Abstract The present study was set out to investigate two-dimensional (2D) and three-dimensional (3D) evaluations of ovarian nervous network development the structural relationship between folliculogenesis gangliogenesis in mouse ovaries. Adult mice tissue samples were collected from follicular luteal phases after cardiac perfusion. Ovarian stained by a Golgi–Cox protocol. Following staining, tissues serially sectioned for imaging. Neural filaments ganglia In both 2D 3D studies, an increase...

10.1038/s41598-021-84835-0 article EN cc-by Scientific Reports 2021-03-10
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