A5049379891- Medical Image Segmentation Techniques
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Advanced Neural Network Applications
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Cryptography and Data Security
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- RNA modifications and cancer
- Customer Service Quality and Loyalty
- Medical Imaging and Analysis
- Cryptographic Implementations and Security
- Consumer Market Behavior and Pricing
- Brain Tumor Detection and Classification
- Consumer Retail Behavior Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Computer Graphics and Visualization Techniques
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Consumer Perception and Purchasing Behavior
- Extracellular vesicles in disease
Korea Advanced Institute of Science and Technology
2019-2025
Kootenay Association for Science & Technology
2025
Dongshin University
2024
St. Jude Children's Research Hospital
2016-2024
Massachusetts General Hospital
2024
Harvard University
2024
Abbott (Sweden)
2024
Kansas State University
2015-2023
Dongguk University
2016-2021
Samsung SDS (South Korea)
2015-2019
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate various biological processes, primarily through interaction with messenger RNAs. The levels of specific, circulating miRNAs in blood have been shown to associate pathological conditions including cancers. These great potential as biomarkers for pathophysiological conditions. In this study we focused on different sample types' effects the spectrum miRNA blood. Using serum and corresponding plasma samples from same individuals,...
Abstract Background Various cancer cells, including those of colorectal (CRC), release microvesicles (exosomes) into surrounding tissues and peripheral circulation. These can mediate communication between cells affect various tumor-related processes in their target cells. Results We present potential roles CRC cell-derived tumor progression via a global comparative microvesicular cellular transcriptomic analysis human SW480 first identified 11,327 mRNAs involved tumorigenesis-related that...
<h3>Background</h3> The mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. MicroRNAs (miRNAs or <i>miRs</i>) are small non-coding RNA molecules that modulate the levels of specific genes and proteins. Identifying expression patterns miRNAs in COPD may enhance our understanding disease. A study was undertaken to determine if differentially expressed lungs smokers with without COPD. miRNA mRNA were compared enrich for biological networks relevant pathogenesis...
Article24 March 2009Open Access A systems approach to prion disease Daehee Hwang Institute for Systems Biology, Seattle, WA, USA I-Bio Program & Department of Chemical Engineering, POSTECH, Pohang, Republic Korea Search more papers by this author Inyoul Y Lee Hyuntae Yoo Nils Gehlenborg Microarray Team, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK Ji-Hoon Cho Brianne Petritis David Baxter Rose Pitstick McLaughlin Research Great Falls, MT, Rebecca Young Doug...
Abstract To identify biomarker candidates associated with early IgA nephropathy (IgAN) and thin basement membrane (TBMN), the most common causes presenting isolated hematuria in childhood, a proteomic approach of urinary exosomes from IgAN TBMN patients was introduced. The results were compared normal group to understand pathophysiological processes these diseases at protein level. exosomes, which reflect processes, collected three groups young adults (early IgAN, TBMN, normal)...
Early cancer detection and disease stratification or classification are critical to successful treatment. Accessible, reliable, informative biomarkers can be medically valuable provide some relevant insights into biology. Recent studies have suggested improvements in detecting malignancies by the use of specific extracellular microRNAs (miRNAs) plasma. In chronic lymphocytic leukemia (CLL), an incurable hematologic disorder, sensitive, early, noninvasive diagnosis better would very useful...
Crosstalk between the Notch and wingless-type MMTV integration site (WNT) signaling pathways has been investigated for many developmental processes. However, this negative correlation WNT/β-catenin activity studied primarily in normal physiological processes which feedback loops both are intact. We found that Notch1 retained capability of suppressing expression WNT target genes colorectal cancers even when β-catenin destruction by adenomatous polyposis coli (APC) complex was disabled....
Abstract Background The molecular pathways involved in the interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches, with global expression data sets, were used to identify perturbed gene networks, gain some understanding of underlying mechanisms, and develop specific hypotheses relevant these chronic diseases. Methods Lung tissue samples from patients different types ILD obtained Tissue Research Consortium total cell RNA was isolated. Global mRNA microRNA profiled...
Abstract Rearrangments in Histone-lysine-N-methyltransferase 2A (KMT2Ar) are associated with pediatric, adult and therapy-induced acute leukemias. Infants KMT2Ar lymphoblastic leukemia (ALL) have a poor prognosis an event-free-survival of 38%. Herein we evaluate 1116 FDA approved compounds primary infant ALL specimens identify sensitivity to proteasome inhibition. Upon exposure this class agents, cells demonstrate depletion histone H2B monoubiquitination (H2Bub1) H3 lysine 79 dimethylation...
Significance Exposure to extremely stressful conditions is common, and the effect of such exposure on neuropsychiatric function well-documented with posttraumatic stress disorder (PTSD). Epidemiological studies reveal a higher risk for cardiovascular among individuals exposed traumatic events. However, underlying molecular mechanism ailments associated yet be fully understood. Our study animal models revealed genetically stress-induced tissue injuries peripheral organs, including heart....
Summary Ideally, disease modeling using patient‐derived induced pluripotent stem cells ( iPSC s) enables analysis of initiation and progression. This requires any pathological features the patient used for reprogramming to be eliminated during generation. Hutchinson–Gilford progeria syndrome HGPS ) is a segmental premature aging disorder caused by accumulation truncated form Lamin A known as Progerin within nuclear lamina. Cellular hallmarks include blebbing, loss peripheral heterochromatin,...
Metabolite identification is a crucial step in mass spectrometry (MS)-based metabolomics. However, it still challenging to assess the confidence of assigned metabolites. We report novel method for estimating false discovery rate (FDR) metabolite assignment with target-decoy strategy, which decoys are generated through violating octet rule chemistry by adding small odd numbers hydrogen atoms. The strategy was integrated into JUMPm, an automated pipeline large-scale MS analysis and also...
In this work we propose a new method for finding gene subsets of microarray data that effectively discriminates subtypes disease. We developed criterion measuring the relevance individual genes by using mean and standard deviation distances from each sample to class centroid in order treat well‐known problem selection, large within‐class variation. Also approach has advantage it is applicable not only binary classification but also multiple problems. demonstrated performance applying...
The mind bomb 1 (Mib1) ubiquitin ligase is essential for controlling metazoan development by Notch signaling and possibly the Wnt pathway. It also expressed in postmitotic neurons regulates neuronal morphogenesis synaptic activity mechanisms that are largely unknown. We sought to comprehensively characterize Mib1 interactome study its potential function neuron utilizing a novel sequential elution strategy affinity purification, which binding proteins were eluted under different stringency...
The discrimination of cancer patients (including subtypes) based on gene expression data is a critical problem with clinical ramifications. Central to solving this the issue how extract most relevant genes from several thousand typical microarray. Here, we propose methodology that can effectively select an informative subset and classify subtypes (or patients) disease using selected genes. We employ kernel machine, Fisher discriminant analysis (KFDA), for use derivatives function perform...
High throughput untargeted metabolomics usually relies on complementary liquid chromatography-mass spectrometry (LC-MS) methods to expand the coverage of diverse metabolites, but integration those is not fully characterized. We systematically investigated performance hydrophilic interaction chromatography (HILIC)-MS and nanoflow reverse-phase (nRPLC)-MS under 8 LC-MS settings, varying stationary phases (HILIC C18), mobile (acidic basic pH), MS ionization modes (positive negative). Whereas...
Metabolomics is increasingly important for biomedical research, but large-scale metabolite identification in untargeted metabolomics still challenging. Here, we present Jumbo Mass spectrometry-based Program of (JUMPm) software, a streamlined software tool identifying potential formulas and structures mass spectrometry. During database search, the false discovery rate evaluated by target-decoy strategy, where decoys are produced breaking octet rule chemistry. We illustrated utility JUMPm...
Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition both processes has been extensively investigated as potential therapeutic avenues in preclinical clinical studies. However, how orchestrated response to oncogenic stress therapies is poorly understood. Here, we demonstrate that jumonji domain containing 6, arginine demethylase, lysine hydroxylase, JMJD6, acts a hub connecting human neuroblastoma. JMJD6 cooperates with MYC...
Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA binding domain, the ETS domain. The 27 known human control multiple biological processes, including cellular proliferation, differentiation, apoptosis, angiogenesis, transformation, and invasion. Overexpression some genes has been linked to numerous malignancies, breast cancers. prostate derived factor (PDEF) is reported be tumor-associated factor. To understand roles PDEF in cancers, we transiently...
Transdifferentiation offers new opportunities in the area of cell replacement therapy; however, molecular mechanism by which transdifferentiation occurs is not fully understood. Our understanding about sophisticated regulations limited yet since their comprehensive proteome have been elucidated. Studies on bone morphogenic protein-2 (BMP2)-induced murine C2C12 cells, a myogenic lineage committed premyoblast, to osteogenic cells can provide full picture dynamic events that occur at level...
Tabular data synthesis has received wide attention in the literature. This is because available often limited, incomplete, or cannot be obtained easily, and privacy becoming increasingly important. In this work, we present a generalized GAN framework for tabular synthesis, which combines adversarial training of GANs negative log-density regularization invertible neural networks. The proposed can used two distinctive objectives. First, further improve quality, by decreasing real records...