A5021470145- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Air Quality and Health Impacts
- Health disparities and outcomes
- Esophageal Cancer Research and Treatment
- Health, Environment, Cognitive Aging
- Ferroptosis and cancer prognosis
- Climate Change and Health Impacts
- Systemic Lupus Erythematosus Research
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Cardiovascular Health and Risk Factors
- Sleep and related disorders
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Pharmacovigilance and Adverse Drug Reactions
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Cancer Risks and Factors
- Diabetes and associated disorders
Zhengzhou University
2018-2025
Advanced Neural Dynamics (United States)
2024
Cancer immunotherapy is an increasingly successful strategy for treating patients with advanced or conventionally drug-resistant cancers. T cells have been proved to play important roles in anti-tumor and tumor microenvironment shaping, while these not explained lung squamous cell carcinoma (LUSC). In this study, we first performed a comprehensive analysis of single-cell RNA sequencing (scRNA-seq) data from the gene expression omnibus (GEO) database identify 72 T-cell marker genes....
Evidence is limited on the incidence of depression and anxiety in relation to active commuting. Our study aimed explore their association examine mediating role inflammatory. This included 240,547 workers UK Biobank. The exposure variable was mode transport used get from work including (walking, cycling, mixed mode) non-active commuting (car or public transport). defined using ICD-10 codes. Cox proportional hazard regression models were ratios (HRs) with anxiety, mediation analyses test...
Abstract Aims Previous studies investigated the associations between sleep traits and cardiac diseases, but evidence for causal inferences was unclear. This study aimed to explore relationship diseases by virtue of Mendelian randomization (MR). Methods results Summary‐level data exposure variables (sleep duration, chronotype, insomnia) outcome (ischaemic heart disease, atrial fibrillation, myocardial infarction, failure) were derived from UK Biobank. Data FinnGen consortium used as a...
High heritability and strong correlation have been observed in breast ovarian cancers. However, their shared genetic architecture remained unclear. Linkage disequilibrium score regression (LDSC) estimation from summary statistics (ρ-HESS) were applied to estimate correlations. Bivariate causal mixture model (MiXeR) was used qualify the polygenic overlap. Then, stratified-LDSC (S-LDSC) identify tissue cell type specificity. Meanwhile, adaptive association test called MTaSPUsSet performed...
Background Studies about the influence of weekday esophagectomy on survival are limited and show conflicting results. This study aimed to explore whether affects patient's outcomes. Methods Patients who underwent in a grade-A tertiary hospital from January 2015 December 2016 were enrolled. The primary outcome was 5-year overall (OS). secondary outcomes disease-free (DFS) days hospitalization. impact surgery OS DFS evaluated with Cox regression, its hospitalization assessed using logistic...
Although genome-wide association studies (GWAS) have a dramatic impact on susceptibility locus discovery, this univariate approach has limitations in detecting complex genotype-phenotype correlations. Multivariate analysis is essential to identify shared genetic risk factors acting through common biological mechanisms of autoimmune/autoinflammatory diseases. In study, GWAS summary statistics, including 41,274 single nucleotide polymorphisms (SNPs) located 11,516 gene regions, were analyzed...
Accumulating evidence substantiated that the immune cells were intricately intertwined with prognosis and therapy of clear cell renal carcinoma (ccRCC). We aimed to construct an signatures (ICS) score model predict ccRCC patients furnish guidance for finding appropriate treatment strategies.Based on The Cancer Genome Atlas (TCGA) database, normalized enrichment (NES) 184 ICSf was calculated using single-sample gene set analysis (ssGSEA). An ICS generated in light univariate Cox regression...
Background The common clinical symptoms and immunopathological mechanisms have been observed among multiple autoimmune diseases (ADs), but the shared genetic etiology remains unclear. Methods GWAS summary statistics of seven ADs were downloaded from Open Targets Genetics Dryad. Linkage disequilibrium score regression (LDSC) was applied to estimate overall correlations, bivariate causal mixture model (MiXeR) used qualify polygenic overlap, stratified-LDSC partitioned heritability reveal...
Background Acute upper respiratory infection (AURI) is a significant disease affecting all age groups worldwide. The differences in the impacts of different temperature change indicators, such as diurnal range (DTR), variation (TV), and between neighboring days (TCN), on AURI morbidity, are not clear. Methods We collected data 87,186 patients during 2014–2019 Zhengzhou. Distributed lag non-linear model was adopted to examine effects indicators AURI. calculated compared attributable fractions...
The association of cardiovascular health (CVH) with asthma risk in U.S. adults remains unclear. This study aimed to explore the Life's Essential 8 (LE8), a measurement CVH, and investigate potential mediating effect inflammation oxidative stress.
This study analyzed adverse events (AEs) associated with inclisiran using the FDA's Adverse Event Reporting System (FAERS) to detect and characterize relevant safety signals.
To assess whether the Life's Essential 8 (LE8) score mediates association of socioeconomic status (SES) with atrial fibrillation (AF) and heart failure (HF).