A5083118714- Wheat and Barley Genetics and Pathology
- Marine Biology and Ecology Research
- RNA and protein synthesis mechanisms
- Mycotoxins in Agriculture and Food
- Marine and coastal plant biology
- Evolutionary Algorithms and Applications
- Fungal and yeast genetics research
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Coral and Marine Ecosystems Studies
- DNA and Nucleic Acid Chemistry
- Model-Driven Software Engineering Techniques
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Yeasts and Rust Fungi Studies
- Legal Education and Practice Innovations
- Studies on Chitinases and Chitosanases
- Bacillus and Francisella bacterial research
- Cancer Genomics and Diagnostics
- Anesthesia and Pain Management
- Environmental DNA in Biodiversity Studies
- Cephalopods and Marine Biology
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
University of British Columbia
2015-2024
Norwich Research Park
2018-2023
John Innes Centre
2018-2023
Billings Clinic
2020
Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that clonal lineage wheat fungus recently spread to Asia and Africa following two independent introductions from South America. Through combination genome analyses laboratory experiments, decade-old pandemic can be controlled Rmg8 resistance gene sensitive strobilurin fungicides. However, also highlight potential clone evolve fungicide-insensitive variants sexually recombine with African...
Molecular phylogenetic analyses of 18S rDNA ( SSU ) gene sequences confirm the placement Crusticorallina gen. nov. in Corallinoideae, first nongeniculate genus an otherwise geniculate subfamily. is distinguished from all other coralline genera by following suite morpho‐anatomical characters: (i) sunken, uniporate gametangial and bi/tetrasporangial conceptacles, (ii) cells linked cell fusions, not secondary pit connections, (iii) epithallus 1 or 2 layers, (iv) a hypothallus that occupies 50%...
Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like that modulates autophagy pathways by binding autophagic membranes and number of proteins, including cargo receptors core components. Throughout plant evolution, ATG8 has expanded from single in algae to multiple isoforms higher plants. However, the degree which have functionally specialized bind distinct proteins remains unclear. Here, we describe comprehensive protein–protein interaction resource, obtained using planta...
PREMISE OF THE STUDY: Phenotypic plasticity and convergent evolution have long complicated traditional morphological taxonomy. Fortunately, DNA sequences provide an additional basis for comparison, independent of morphology. Most importantly, by obtaining from historical type specimens, we are now able to unequivocally match species names genetic groups, often with surprising results. Methods: We used integrative taxonomic approach identify describe Northeast Pacific pinnately branched in...
Plant pathogens deliver effector proteins to reprogramme a host plants circuitry, supporting their own growth and development, whilst thwarting defence responses. A subset of these effectors are termed avirulence factors (Avr) can be recognised by corresponding resistance (R) proteins, creating strong evolutionary pressure on pathogen Avr that favours modification/deletion evade the immune response. Hence, identifying tracking allele frequencies in population is critical for understanding...
In both animals and plants, messenger (m)RNA export has been shown to contribute immune response regulation. The Arabidopsis nuclear protein MOS11, along with the nucleoporins MOS3/Nup96/SAR3 Nup160/SAR1 are components of mRNA machinery immunity mediated by nucleotide binding leucine-rich repeat receptors (NLR). human MOS11 ortholog CIP29 is part a small complex three additional members: RNA helicase DDX39, ALY, TAF15b. We systematically assessed biological roles homologs these proteins in...
This is the first report of a coralline genus with both geniculate (upright fronds non-calcified joints) and nongeniculate species that has been verified by DNA sequence data. Two (crustose) Bossiella are recognized, B. mayae sp. nov. exarticulata sequencing lectotype specimen Pseudolithophyllum whidbeyense revealed this name had misapplied instead belongs to an undescribed in Hapalidiales. Phylogenetic analyses concatenated sequences (psbA, rbcL, COI-5P) indicate represent phenotypic...
Abstract Genomes encode for genes and the regulatory signals that enable those to be transcribed, are continually shaped by evolution. Genomes, including of human yeast, numerous elements transcripts have limited evidence conservation or function. Here, we sought create a genomic null hypothesis quantifying gene activity evolutionarily naïve DNA, using RNA-seq distant DNA expressed in yeast computational predictions random cells tissues. In found >99% bases as part one more transcripts....
ABSTRACT Wheat, the most important food crop, is threatened by a blast disease pandemic. Here, we show that clonal lineage of wheat fungus recently spread to Asia and Africa following two independent introductions from South America. Through combination genome analyses laboratory experiments, decade-old pandemic can be controlled Rmg8 resistance gene sensitive strobilurin fungicides. However, also highlight potential clone evolve fungicide-insensitive variants sexually recombine with African...
This study examined nausea and vomiting (N/V) in hospitalized patients following the use of inhaled peppermint essential oil (aromatherapy) compared to combined aromatherapy/antiemetics or antiemetics alone.A total 103 were offered one three options control N/V. Patient choice was considered holistic trial design so that not denied either antiemetics. Patients rated 0 10 on Edmonton Symptom Assessment Scale at symptom onset within 60 minutes intervention.Only subjects enrolled antiemetic...
Abstract ATG8 is a highly-conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and numerous proteins, including cargo receptors core components. Throughout plant evolution, has expanded from single in algae to multiple isoforms higher plants. However, the degree which have functionally specialized bind distinct proteins remains unclear. Here, we describe comprehensive protein-protein interaction resource, obtained using planta immunoprecipitation...
Generate Indexes for Libraries (GIL) is a software tool generating primers to be used in the production of multiplexed sequencing libraries. GIL can customized numerous ways meet user specifications, including length, modality, color balancing, and compatibility with existing primers, produces ordering demultiplexing-ready outputs.GIL written Python freely available on GitHub under MIT license: https://github.com/de-Boer-Lab/GIL accessed as web-application implemented Streamlit at...
Summary Next-generation sequencing allows samples to be multiplexed by adding a unique DNA index each sample. Multiplexing greatly reduces the price of large numbers samples, yet minimum cost per sample remains high when using commercially available indexing kits and designing custom indexes is challenging. To address these issues, we created GIL (Generate Indexes for Libraries), software tool that designs primers producing libraries. can customized in numerous ways meet user specifications,...
Functional characterization of effector proteins fungal obligate biotrophic pathogens, especially confirmation avirulence (Avr) properties, has been notoriously difficult, due to the experimental intractability many these organisms. Previous studies in wheat have shown promising data suggesting type III secretion system (T3SS) bacteria may be a suitable surrogate for delivery and detection Avr properties effectors. However, systems were tested absence confirmed Here, we two previously...