A5015592322- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Infant Nutrition and Health
- Diabetes and associated disorders
- Eosinophilic Esophagitis
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Digital Imaging for Blood Diseases
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Transgenic Plants and Applications
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Vitamin C and Antioxidants Research
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Child Nutrition and Water Access
- Herpesvirus Infections and Treatments
- Immune responses and vaccinations
Erasmus MC
2021-2023
Wageningen University & Research
2018-2023
Erasmus University Rotterdam
2020-2023
University of Zurich
2012-2020
A novel B cell subset that produces proangiogenic cytokines is increased in pathologies associated with angiogenesis.
The Mas-related G-protein-coupled receptor X2 (MRGPRX2) is prominently expressed by mast cells and induces degranulation upon binding different ligands. Its activation has been linked to various cell-related diseases, such as chronic spontaneous urticaria, atopic dermatitis asthma. Therefore, inhibition of MRGPRX2 activity represents a therapeutic target for these conditions. However, the exact pathophysiology this still unknown. In vitro research with often hampered technical limitations...
Innate immune memory, also termed “trained immunity” in vertebrates, has been recently described a large variety of plants and animals. In most cases, trained innate immunity is induced by pathogens or pathogen-associated molecular patterns (PAMPs), associated with long-term epigenetic, metabolic, functional reprogramming. Interestingly, recent findings indicate that food components can mimic PAMPs effects induce immunity. The aim this study was to investigate whether bovine milk its human...
Ageing is associated with a changing immune system, leading to inflammageing (increased levels of inflammation markers in serum) and immunosenescence (reduced cells reduced responses towards pathogens). This results vaccination increased infections elderly. Much known about the adaptive system upon ageing, but less innate system. Therefore, aim this study was compare function Toll like receptor (TLR)-mediated between elderly young adult women. To end, women were compared effect ageing on...
During aging the immune system is dysregulated. Especially plasmacytoid dendritic cells (pDCs) and myeloid DCs (mDCs) have reduced Toll like receptor (TLR)-mediated responses resulting in increased susceptibility to infections. Consumption of bovine lactoferrin (bLF) has been shown reduce infections with viruses. Galacto-oligosacharides (GOS) vitamin D are associated pro-inflammatory cytokine levels serum, TLR7/8 responses, respectively. A double-blind placebo-controlled nutritional...
Background: Nutritional supplements, such as bovine lactoferrin (bLF), have been studied for their immunomodulatory properties, but little is known of effect on the gut microbiota composition elderly when supplemented alone or combined with other nutritional supplements prebiotics and micronutrients. In present study, fecal samples from a double-blind, placebo-controlled intervention study were analysed. At baseline (T1), 25 women distributed into two groups receiving dietary (n = 12)...
Accelerating the induction of tolerance to cow’s milk (CM) reduces burden allergy (CMA). In this randomised controlled intervention study, we aimed investigate a novel heated cow protein, iAGE product, in 18 children with CMA (diagnosed by paedriatric allergist). Children who tolerated product were included. The treatment group (TG: n = 11; mean age 12.8 months, SD 4.7) consumed daily their own diet, and control (CG: 7; 17.6 3.2) used an eHF without any consumption. each group, 2 had...