A5051325704- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- High-Velocity Impact and Material Behavior
- Inflammatory Myopathies and Dermatomyositis
- Thin-Film Transistor Technologies
- Mechanical Behavior of Composites
- Energetic Materials and Combustion
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- Metal and Thin Film Mechanics
- MXene and MAX Phase Materials
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vasculitis and related conditions
- Structural Response to Dynamic Loads
- Mycobacterium research and diagnosis
- 2D Materials and Applications
- Cardiac tumors and thrombi
- Ultrasonics and Acoustic Wave Propagation
- Proteoglycans and glycosaminoglycans research
- GaN-based semiconductor devices and materials
- Electromagnetic Launch and Propulsion Technology
- Iron and Steelmaking Processes
- Glycosylation and Glycoproteins Research
- Semiconductor materials and devices
- Melanoma and MAPK Pathways
- Occupational and environmental lung diseases
Toho University Medical Center Sakura Hospital
2019-2024
Toho University
2019-2024
Weatherford College
2023
Tohoku University
2020
Osaka Institute of Technology
2017-2019
Tokai University
2017
Keio University
2016
Toray (China)
2014
Ritsumeikan University
2014
Gunma University
2010
In order to decrease CO2 emission from the ironmaking process, an increasing use of hydrogen in blast furnace (BF) is a promising way. this case, properties iron ore sinter such as reducibility and strength need be optimized because reduction oxide endothermic reaction temperature distribution BF drastically changes. study, effect concentration reducing gas on changes mineral phases during evaluated. Mineral composition ten types samples was analyzed by XRD image analysis. Sinter sample...
It is well known that malignant cells show procoagulant activity, which associated with their metastatic potential. Thrombin, the key enzyme of blood coagulation system, generated around tumor cells, promoting migration and metastasis cells. In this study, we evaluated effect argatroban, a specific thrombin inhibitor, on B16BL6 melanoma vitro argatroban dose-dependently inhibited cell migration, maximum inhibition being observed in presence 10 microM (p < 0.0001). order to investigate...
Coronavirus disease 2019 (COVID-19) is a life-threatening respiratory characterized by severe acute infection. In some cases, COVID-19 symptoms may persist for long term, posing significant social problem. Long-term resemble those observed in various autoimmune diseases, such as dermatomyositis and polymyositis. this report, we present the case of 55-year-old woman who had been experiencing persistent dyspnea on exertion since contracting month ago was subsequently diagnosed with...
The prognosis of patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer has improved significantly since the advent EGFR tyrosine kinase inhibitors (EGFR-TKIs). We aimed to investigate relationship between patient characteristics, genotype, therapeutic agents, and cancer.
The relationship between the lower airway microbiota in humans and respiratory illness has gained attention recently. However, nontuberculous mycobacterial lung disease (NTM-LD) is not fully understood yet. We conducted a study to characterize Mycobacterium avium complex (MAC-LD), representative subclass of NTM-LD. subject sample included 25 patients clinically suspected having mild MAC whose condition could be diagnosed using sputum culture. Upon testing antibodies (anti-glycopeptidolipid...
Sapphire is an attractive engineering material for the cover glass of smartphones and wristwatches because its high hardness resistance to corrosion, wear, heat. However, rate tool wear brittle chippings around holes are serious problems associated with drilling sapphire. To enhance accuracy efficiency process on sapphire, this paper presents a novel tool-path strategy using helical milling along various path patterns. Experimental results show that proposed method successfully reduces holes.
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease of unknown aetiology that causes recurrent episodes diffuse alveolar haemorrhage (DAH). A male patient in his 50s had repeatedly experienced hemoptysis for the past 6 years, along with decrease diffusing capacity and chronic respiratory failure. After 6-year follow-up, sudden exacerbation failure, he was hospitalised. CT chest revealed infiltrates, whereas bronchoalveolar lavage hemosiderin-laden macrophages. Thus, diagnosed DAH. As...
Objective Patients with idiopathic interstitial pneumonia (IIP) often test positive for systemic scleroderma-specific autoantibodies (SSc-Ab), even if they do not meet the diagnostic criteria scleroderma (SSc). However, significance of SSc-Ab in IIP is unknown. Methods We retrospectively studied medical records all patients suspected lung disease (ILD) who visited our center between January 2016 and December 2021. evaluated association subtypes clinical characteristics, prognosis, incidence...
Abstract BRAF is a mediator that activates the mitogen‐activated protein kinase pathway. A mutation in can cause abnormal pathway activation, leading to cell proliferation. In Phase II study, combination therapy of inhibitor dabrafenib and MEK trametinib was found be effective non‐small lung cancer (NSCLC) patients with mutation. However, this study has limited efficacy safety data for elderly patients. We present case patient who started treatment at 87 years old showed good prognosis,...
Patients with idiopathic interstitial pneumonia (IIP) often exhibit positivity for myositis-specific antibodies (MSA). However, the significance of this finding remains unclear. In study, we investigated association MSA prognosis and risk acute exacerbation in patients IIP.
A novel experimental method was proposed for characterizing the compressive properties of composite materials under impact loading. Split Hopkinson pressure bar system employed to carry out dynamic compression tests. The stress-strain relations could be precisely estimated by method, where ramped input, generated plastic deformation a zinc buffer, effective reduce oscillation stress field in specimen. longitudinal strain gage area from nominal area, and consequently failure process grasped...
The antifibrotic drugs, nintedanib and pirfenidone, inhibit the decline in forced vital capacity patients with idiopathic pulmonary fibrosis (IPF). Nintedanib also inhibits onset of acute exacerbation reduces risk all-cause mortality. However, their effectiveness real-world practice remains unclear. Our study aimed to investigate changes capacity, survival period, causes death, factors for mortality IPF receiving drugs.
The mechanism of progressive airway destruction in incurable chronic infection the lung - termed pulmonary Mycobacterium avium complex (pMAC) disease is currently unknown. involvement oxidative stress a variety respiratory diseases has been previously reported. It hypothesized that may be involved progression pMAC disease.The study included 28 untreated patients with disease. level serum was quantitatively evaluated through diacron reactive oxygen metabolites (d-ROMs) test, which indirectly...
Optical absorption in amorphous InGaZnO 4 films was examined by optical transmittance and photothermal spectroscopy using individual cantilever. The have bandgap of ~3.5 eV, Urbach tail mid-gap at 2.0-3.0 eV. Mid-gap reduced thermal annealing 300 °C an atmosphere. This observation indicates that heat-induced structural change causes reduction gap states films.
背景.原発性悪性心膜中皮腫は非常に稀な疾患である.1剖検例と本邦における近年20年間の症例報告の集計を報告する.症例.58歳女性.呼吸困難を主訴に近医を受診し,胸部X線で縦隔腫瘍を疑われて当院へ紹介受診となった.胸部CTでは心基部に主要血管や主気管支を圧排する100×95 mmの巨大な縦隔腫瘍と軽度心嚢液貯留を認めた.エコーガイド下経胸壁針生検と画像所見から原発性悪性心膜中皮腫と診断した.Cisplatinとpemetrexedを投与し気道確保目的に緩和的放射線治療を開始したが,約2か月後に心タンポナーデ,腫瘍性DICを発症して永眠された.剖検では心嚢内に血腫と粘稠な血性心嚢液が認められ心タンポナーデの原因が判明した.また,上皮型の悪性心膜中皮腫であることがわかった.結論.原発性悪性心膜中皮腫の初発症状は心嚢液貯留を伴う心不全兆候が多い.心嚢液での診断率は低いため,早期診断のために外科的生検を要する.プラチナ製剤とpemetrexedによる化学療法が有効である.
A novel experimental method was proposed for characterizing the compressive properties of composite materials under impact loading. Split Hopkinson pressure bar system employed to carry out dynamic compression tests. The stress-strain relations could be precisely estimated by method, where ramped input, generated plastic deformation a zinc buffer, effective reduce oscillation stress field in specimen. longitudinal strain gage area from nominal area, and consequently failure process grasped...
A novel experimental method for characterizing properties of carbon fiber-reinforced plastics under impact loading was proposed in this study. The dynamic compressive test carried out by using a Split Hopkinson Pressure Bar (SHPB) system. zinc buffer used to reduce the oscillation specimen, and consequently relation stress-strain could be estimated precisely. longitudinal strain gage area from nominal deformation area, failure process grasped detail stress-strain. strength material slightly...
2015 International Conference on Solid State Devices and Materials,Improving Crystalline Quality of Sputtering Deposited MoS<sub>2</sub> Thin Film by Post-Sulfurization Annealing Using (t-C<sub>4</sub>H<sub>9</sub>)<sub>2</sub>S<sub>2</sub>
2016 International Conference on Solid State Devices and Materials,Centimeter-scale High-performance Few-layer MoS<sub>2</sub> Fabricated by RF Magnetron Sputtering Subsequent Post-deposition Annealing
<title>Abstract</title> Background Patients with idiopathic interstitial pneumonias (IIP) often exhibit positivity for myositis-specific antibodies (MSA). However, the significance of MSA remains unclear. In this study, we investigated association prognosis and risk acute exacerbation in patients IIP. Methods We retrospectively reviewed medical records IIP examined impact each subtype on survival exacerbation. Results Of 240 IIP, 48 (20%) exhibited MSA. The subtypes included: PL-7...