A5039820357- Mycotoxins in Agriculture and Food
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Kruppel-like factors research
- Lipid metabolism and biosynthesis
- Animal Nutrition and Physiology
- Wheat and Barley Genetics and Pathology
- Insect and Pesticide Research
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Computational Drug Discovery Methods
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Reproductive Physiology in Livestock
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- Vitamin K Research Studies
- Cancer-related Molecular Pathways
- Cholesterol and Lipid Metabolism
- RNA Research and Splicing
- Heat shock proteins research
Cornell University
2015-2024
Weill Cornell Medicine
2018-2024
Tri-Institutional Therapeutics Discovery Institute
2022-2023
Mayo Clinic in Arizona
2019
Columbia University Irving Medical Center
2019
Texas Health Dallas
2019
Sichuan Agricultural University
2014
Rutgers, The State University of New Jersey
2012
This study was designed to establish if Curcumin (CM) alleviates Aflatoxin B₁ (AFB₁)-induced hepatotoxic effects and determine whether alteration of the expression cytochrome P450 (CYP450) isozymes is involved in regulation these chick liver. One-day-old male broilers (
Integrated stress response (ISR) is a signaling system in which phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by stress‐specific kinases and subsequent activation transcription (ATF) 4 help restore cellular homeostasis following exposure to environmental stresses. ISR has been observed metabolic diseases, including hepatic steatosis (HS), steatohepatitis (SH), insulin resistance (IR), but it remains unclear whether contributes disease pathogenesis or represents an...
Cells composing the mammary secretory compartment have evolved a high capacity to secrete not only proteins but also triglycerides and carbohydrates. This feature is illustrated by mouse, which can nearly twice its own weight in milk proteins, lactose over short 20-day lactation. The coordination of synthesis export products other cells orchestrated part transcription factor X-box binding protein 1 (XBP1). To assess role XBP1 epithelial (MEC), we studied floxed female mice lacking (wild...
Mammals meet the increased nutritional demands of lactation through a combination feed intake and collection adaptations known as adaptive metabolism (e.g., glucose sparing via insulin resistance, mobilization endogenous reserves, metabolic efficiency reduced thyroid hormones). In modern dairy cow, predominates over at onset develops concurrently with reduction in plasma leptin. To address role leptin early lactation, we asked which could be countered by constant 96-h intravenous infusion...
Two experiments were conducted to optimize the fermentation of cottonseed meal by Cellulosimicrobium funkei (C. funkei) for ability bacteria degrade aflatoxin B1 (AFB1) and then evaluate bacterial detoxification in ducklings. In experiment 1, C. was improved changing inoculation amounts 10% (108 cfu/mL), using a 1:0.5 material water ratio at 35°C temperature 144 h reaction duration, which resulted an 83.4% biodegradation AFB1. 2, 112 one-day-old male Cherry Valley ducklings randomly...
Summary Two experiments were conducted to screen microorganisms with aflatoxin B 1 ( AFB ) removal potential from soils and evaluate their ability in reducing the toxic effects of ducklings. In experiment 1, we screened 11 isolates that showed biodegradation ability, one exhibited highest (97%) was characterized identified as C ellulosimicrobium funkei . ). 2, 80 day‐old herry V alley ducklings divided into four groups replicates five birds each used a 2 by factorial trial design, which main...
Modern dairy cows meet the energy demand of early lactation by calling on hormonally driven mechanisms to increase use lipid reserves. In this context, we recently reported that fibroblast growth factor-21 (FGF21), a hormone required for efficient reserves in rodents, is upregulated periparturient cows. Increased plasma FGF21 coincides with elevated circulating concentrations glucagon (GCG) and nonesterified fatty acids (NEFA). To assess relative contribution these factors regulating FGF21,...
Mammary epithelial cell (MEC) number is an important determinant of milk production in lactating dairy cows. IGF-I increases IGF binding protein-3 (IGFBP-3) these cells, which plays a role its ability to enhance proliferation. In the present study, we show that apoptotic factor anisomycin (ANS) also IGFBP-3 mRNA and protein dose- concentration-dependent manner mirrors activation caspase-3 -7, with significant both caspase observed by 3 h. Knock-down small interfering (si) RNA attenuated ANS...
Cyclic AMP-responsive element-binding protein H (CREBH encoded by Creb3l3) is a transcription factor that regulates the expression of genes control lipid and glucose metabolism as well inflammation. CREBH upregulated in liver under conditions overnutrition, mice globally lacking gene
Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, which allosterically modulates activity. Them1 highly expressed in thermogenic adipose tissue, where it functions suppress energy expenditure by limiting rates of fatty acid oxidation, and induced markedly liver response high fat feeding, suppresses oxidation...
Activation of thermogenic brown adipose tissue (BAT) and inducible beige (BeAT) is triggered by environmental or metabolic stimuli, including cold ambient temperatures nutrient stress. Thioesterase superfamily member 1 (Them1), a long-chain fatty acyl-CoA thioesterase that enriched in BAT, suppresses acute cold-induced thermogenesis. Here, we demonstrate Them1 expression was induced BAT BeAT the carbohydrate response element binding protein (ChREBP) to chronic exposure activation integrated...
Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to C-terminal lipid-sensing START domain, which allosterically modulates activity. Them1 highly expressed in thermogenic adipose tissue, where it functions suppress energy expenditure by limiting rates of fatty acid oxidation, and induced markedly liver response high fat feeding, suppresses oxidation promotes glucose production. Them1-/- are protected...
Neurodegenerative diseases such as Alzheimer¡¦s disease (AD) and Parkinson¡¦s (PD) are characterized by the selective loss of subsets neurons in central nervous system (CNS). While increasing evidence reveals a combinatory causes involving both genetics environmental factors, molecular etiology underlying pathogenesis AD PD remains incompletely understood. Suppressor enhancer lin‐12 1 Like (SEL1L), which encodes an endoplasmic reticulum (ER) membrane protein, is highly expressed CNS neurons....
Cholesterol is a physiologically essential sterol synthesized in the liver. homeostasis liver regulated by network of genes including those encoding catalytic enzymes and transcription factors. Suppressor Enhancer Lin‐12 1 Like (SEL1L) encodes an endoplasmic reticulum (ER) membrane protein that highly expressed To investigate possible role SEL1L regulation cholesterol metabolism, we have developed specific mouse model ( LKO). LKO mice show comparable body growth to wild‐type on normal diet....