A5019878824- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Vestibular and auditory disorders
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Molecular Biology Techniques and Applications
- Neurobiology of Language and Bilingualism
- Neurological Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Body Contouring and Surgery
- Bariatric Surgery and Outcomes
- Cancer-related cognitive impairment studies
- Veterinary Orthopedics and Neurology
- Comparative Animal Anatomy Studies
- Nutrition and Health in Aging
- Optical Imaging and Spectroscopy Techniques
- Atomic and Subatomic Physics Research
Université de Toulouse
2017-2025
Inserm
2017-2025
Université Toulouse III - Paul Sabatier
2017-2025
Centre de recherche cerveau et cognition
2020-2024
Hôpital Rangueil
2023
Cognitive Neuroimaging Lab
2022
Centre National de la Recherche Scientifique
2020
New York Proton Center
2020
American Headache Society
2020
ABSTRACT Background and Purpose Working memory, a primary cognitive domain, is often impaired in pediatric brain tumor survivors, affecting their attention processing speed. This study investigated the long‐term effects of treatments, including surgery, radiotherapy (RT), chemotherapy (CT), on working memory tracts children with posterior fossa tumors (PFTs) using resting‐state functional MRI (rs‐fMRI) diffusion tractography. Methods included 16 medulloblastoma (MB) survivors treated...
Abstract Background Thalamic strokes produce neurological, cognitive, and behavioral symptoms depending on the thalamic nuclei involved. While traditionally associated with severe cognitive deficits, recent studies suggest more modest impairments. This study aims to identify factors that influence severity of impairment following stroke. Methods We recruited 40 patients (mean age 51.1) chronic isolated stroke 45 healthy subjects 48.5) who underwent neuroimaging neuropsychological assessment....
To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers disease progression the cerebellar subtype (MSA-C). Reliable biomarkers for tracking MSA are urgently needed. Although several studies have explored neuroimaging markers, imaging measures that reliable reproducible at individual-level lacking. Longitudinal three-dimensional (3D)-T1 images from cohorts 21 subjects with probable MSA-C, 19...
Abstract Objective To determine the rates of brain atrophy progression in vivo patients with multiple system (MSA). Background Surrogate biomarkers disease are a major unmet need MSA. Small‐scale longitudinal studies MSA using magnetic resonance imaging (MRI) to assess have produced inconsistent results. In recent years, novel MRI post‐processing methods been developed enabling reliable quantification an automated fashion. Methods Serial 3D‐T1‐weighted assessments (baseline and after 1 year...
Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions migraine, especially migraine with aura (MA). is functionally divided into 3 subregions, the dorsoanterior, ventroanterior posterior insula respectively related to cognition, emotion, somatosensory functions. This study aimed at investigating functional connectivity of subregions MA.Twenty-one interictal patients MA were compared 18 healthy controls (HC) 12 without (MO) scanned MRI during...
Posterior fossa tumors represent two thirds of brain in children. Although progress treatment has improved survival rates over the past few years, long-term memory impairments survivors are frequent and have an impact on academic achievement. The hippocampi, cerebellum cerebellar-cortical networks play a role several systems. They affected not only by location tumor itself its surgical removal, but also supratentorial effects complementary treatments, particularly radiotherapy. IMPALA study...
Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for investigation of domestic mammals. In the equine species, such could be useful to improve our knowledge about structural connectivity or assess changes white matter tracts potentially associated with neurodegenerative diseases. The goals present study were establish feasibility DTI tractography in and provide morphologic description most...
Introduction Cell transplantation is an innovative therapeutic approach after brain injury to compensate for tissue damage. To have real-time longitudinal monitoring of intracerebrally grafted cells, we explored the feasibility a molecular imaging using thymidine kinase HSV1-TK gene encoding and [18F]FHBG as reporter probe image enzyme expression. Methods A stable neuronal cell line expressing was developed with optimised mammalian expression vector ensure long-term transgene After...
Tractography is a technique used to trace the pathways of brain using noninvasive diffusion tensor imaging (DTI) data. It becoming increasingly popular for investigating brains domestic mammals and other animals with myelinated fibers but principle DTI can also apply those unmyelinated fibers. In case camels, tractography promising method enhancing current knowledge brain's structural connectivity identifying white-matter tract changes potentially linked neurodegenerative pathologies. The...
Objective Intervertebral disk (IVD) degeneration usually occurs earlier in chondrodystrophic dog breeds than other breeds. Spinal cord compression secondary to IVD is the most common cause of myelopathy these dogs. Standard magnetic resonance imaging (MRI) sequences permit identification and its consequences on adjacent neurological structures. In human medicine, quantitative MRI sequences, such as magnetization transfer ratio (MTR) are developed used detect early degeneration. This...
Abstract Objective Thalamic strokes produce a range of neurological, cognitive, and behavioral symptoms depending on the thalamic nuclei involved. While are traditionally associated with severe cognitive deficits, recent studies suggest more modest impairments. This study aims to identify factors that influence severity impairment following stroke. Methods We recruited 40 patients (median age 51) chronic isolated stroke 45 healthy subjects. All subjects underwent neuroimaging...
Because of its anatomical situation, the brainstem is difficult to image. With whole brain acquisitions, we end up with artifactual images. Our team developed a brainstem-dedicated T2*-weighted MRI acquisition method. Using this, imaged sixteen healthy volunteers. This sequence was repeated 5 times for each volunteer. protocol also consisted three-dimensional T1-weighted whole-brain sequence. The aim reduce number acquisitions required visualize nigrosome-1 by using image processing methods....
Motivation: Some cerebrovascular function alterations and cognitive changes are related to ageing. We investigated this issue in marmoset monkeys, offering human-like physiological models. Goal(s): aimed at describing age-related brain hemodynamics their potential interest as early markers of normal/pathological Approach: analyzed blood flow intracranial arteries sinuses by using ECG-synchronized PCMRI. Results: The arterial (basilar trunk carotids) inflow venous (inferior superior ) outflow...
Introduction The locus coeruleus (LC) is one of the brainstem nuclei that may be activated during migraine attack. As LC contains neuromelanin, a by‐product norepinephrine synthesis, it can delineated in vivo using neuromelanin sensitive magnetic resonance imaging (MRI). content has been suggested to reflect previous activation. We investigated MRI contrast patients with aura (MWA) and its correlation features. Methods This matched cohort study compared 23 MWA aged 30‐55 without comorbidity,...
Now that access of large domestic mammals to high-field MRI becomes more common, techniques initially implemented for human patients can be used the structural and functional study brain these animals. Among them, susceptibility-weighted imaging (SWI) is a recent technique obtained from gradient echo (GE) allow an excellent anatomical tissue contrast non-invasive assessment iron content. The goal this was design optimal GE SWI protocol in dogs undergoing examination 3-Tesla scanner. This...