A5026614586- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Gout, Hyperuricemia, Uric Acid
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Analytical Methods in Pharmaceuticals
- Liver physiology and pathology
- Effects and risks of endocrine disrupting chemicals
- Protein Interaction Studies and Fluorescence Analysis
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Colorectal Cancer Treatments and Studies
- Metabolomics and Mass Spectrometry Studies
- Biological and pharmacological studies of plants
- Drug-Induced Hepatotoxicity and Protection
- Chromatography in Natural Products
- Polysaccharides and Plant Cell Walls
- Gastrointestinal motility and disorders
- Phytochemistry and Bioactivity Studies
- Silymarin and Mushroom Poisoning
First Affiliated Hospital of Henan University
2019-2025
Second Affiliated Hospital of Dalian Medical University
2024
Shenyang Medical College
2024
Dalian Medical University
2024
Yanbian University
2012-2023
China Pharmaceutical University
2011-2019
State Key Laboratory of Natural Medicine
2019
Ministry of Natural Resources
2012
Northeast Forestry University
2008-2009
Southwest Forestry University
2008
A universal and promising route for screening of high-quality enzyme inhibitors from herbal medicines.
A new phenanthrene compound, 7-(4-hydroxybenzyl)-8-methoxy-9,10- dihydrophenanthrene-2,5-diol (HMD), along with five known compounds (Coelonin, DD, Shancidin, HDP and MDD) were isolated from the roots of Cymbidium faberi Rolfe. (CFR). Their structures identified using various spectroscopic methods. These reported for first time in genus. All tested by radical-scavenging ability against 1,1-diphenyl-2-picryl-hydrazyl (DPPH), cytotoxic activity three human cancer cell lines inflammatory...
Distillate was obtained in different processing cycles of processed Rehmanniae Radix (PRR). In this study, we investigated the chemical compositions distillates 1 (Dis1) to 9 (Dis9) via GC-MS and LC-MS. Differences between Dis1-Dis9 were noticeable. A total 13 21 compounds detected LC-MS, respectively, including organic acids, furans, alcohols, iridoid glycosides, phenylpropanoid saccharides. The relative contents compound 2,5-hydroxymethylfurfural furans all gradually increased with...
ABSTRACT Ergothioneine (EGT) is a diet‐derived natural sulfur‐containing amino acid that exhibits strong anti‐oxidant and anti‐inflammation activities. Oxidative stress chronic inflammatory injury are predominant pro‐fibrogenic factors. Therefore, EGT may have therapeutic potential against liver fibrosis; however, its underlying mechanism incompletely understood. This study aimed at investigating the protective effects of on fibrosis based metabonomics network pharmacology. A mouse model was...
Excess reactive oxygen species can cause cellular damage, and are involved in many pathological processes such as inflammation, atherosclerosis cancer.
Abstract A method based on enzyme blocking combined with ultrafiltration liquid chromatography–mass spectrometry (LC–MS) has been developed to identify xanthine oxidase (XOD) inhibitors in the roots of Lindera reflexa Hemsl (LR) and determine their binding positions. Allopurinol febuxostat, known XOD inhibitors, which occupy different positions XOD, were used as blockers pre‐incubated XOD. Then LR extract was incubated without allopurinol‐blocked febuxostat‐blocked before LC–MS performed. By...
Peach blossom comes from the flower of Prunus persica (L.) Batsch, which is used as herbal tea and medicine in China Korea. It could promote defecation alleviate abdominal pain. In this paper, methods, ultra-performance liquid chromatography (UPLC) method coupled with electrospray ionization hybrid linear trap quadrupole orbitrap mass spectrometry (LTQ OrbitrapMS) UPLC system a diode array detector (DAD), were developed for qualitative quantitative analysis flavonoids phenolic acids peach...
Abstract A LC‐MS/MS method for the determination of a hydrophilic paclitaxel derivative 7‐xylosyl‐10‐deacetylpaclitaxel in rat plasma was developed to evaluate pharmacokinetics rats. 7‐Xylosyl‐10‐deacetylpaclitaxel and docetaxel (IS 7‐xylosyl‐10‐deacetylpaclitaxel) were extracted from with acetic ether analyzed on Hypersil C 18 column (4.6 × 150 mm i.d., particle size 5 µm) mobile phase ACN/0.05% formic acid (50:50, v/v). The analytes detected using an ESI MS/MS multiple reaction monitoring...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease with a 0.5% prevalence worldwide. Inflammation, periosteal proliferation and joint destruction are the main clinical symptoms of RA. Typhonii Rhizoma (TR) dry tuber Araceae plant Typhonium giganteum Engl, possesses many uses such as dispelling obstructive wind‐phlegm relieving pain. It used for treatment arthromyodynia However, mechanism action remains unclear. In this study, we first evaluated effects TR in type II collagen‐induced...
A new strain, GH9, having ß-glucosidase activity was isolated from the soil of wild ginseng using Esculin-R2A agar. It shows strongest activities to convert ginsenoside Rb1 minor ginsenosides compound K. The transformation products were identified by thin layer chromatography (TLC) and high performance liquid (HPLC), strain GH9 was found transform major K as key sole product. optimal biotransformation conditions with C-K obtained follows: media, yeast broth (YB);...
Constipation is a multifactorial health problem resulting from systemic or neurologic disorders including medication. Peach blossom, an edible flower, could promote defecation, urination, and improve abdominal pain. However, the active components mechanisms of action remain unclear. In present study, we established loperamide-induced mice constipation model to validate anti-constipation activity peach blossom. Some classical biomarkers for constipation, fecal water content, gastrointestinal...
A method for the determination of tetrabromobisphenol-A (TBBP-A) in electronic products was developed by gas chromatography-mass spectrometry (GC-MS). The TBBP-A extracted from automatic digestion oven with acetone and concentrated evaporation solvent. It redissolved methylene chloride, back-extracted potassium carbonate solution reacted acetic anhydride. derivative hexane determined GC-MS. linear calibration curve obtained range 0.25 - 5.0 mg/L a correlation coefficient 0.996. detection...
Abstract In this paper, an HPLC peak fractionation approach combined with homogeneous time-resolved fluorescence analysis is proposed for screening epidermal growth factor receptor inhibitors from Rhei Radix et Rhizoma. With approach, the amount of sample used a single run sufficient performing multiple assay due to miniaturization ability technology. This allows improving stability and repeatability activity each fraction. From total 26 fractions collected Rhizoma extract, 13 exhibit...
This study investigates how three different extraction methods impact the biological activity and structure characteristics of polysaccharides from flower Panax ginseng C.A. Meyer. The were named AHEP, DWEP ANEP that extracted by acid solvent (HCL 0.01 mol/L), distilled water alkali (NaOH mol/L) respectively. results showed yield was highest compared to others, as well capacity antioxidant, cholate-binding inhibition α-glucosidase better than AHEP (P<0.05). Moreover, retention rate in vitro...