A5020549190- Pleural and Pulmonary Diseases
- Lymphoma Diagnosis and Treatment
- Occupational and environmental lung diseases
- Ultrasound in Clinical Applications
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Congenital Diaphragmatic Hernia Studies
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Diverticular Disease and Complications
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Anorectal Disease Treatments and Outcomes
- Renal and related cancers
- Biliary and Gastrointestinal Fistulas
- Polyomavirus and related diseases
Althaia
2010-2024
Universitat de Vic - Universitat Central de Catalunya
2019-2024
Universitat de Barcelona
2011
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2011
Fundació CTM Centre Tecnològic
1998
Clínica Girona
1995
Hospital Universitari de Girona Doctor Josep Trueta
1994
Abstract Mantle cell lymphoma (MCL) is a mature B‐cell neoplasm with an aggressive behavior, characterized by the t(11;14)(q13;q32). Several secondary genetic abnormalities potential role in oncogenic process have been described. Studies of large MCL series using conventional cytogenetics, and correlating proliferation survival, are scarce. We selected 145 cases at diagnosis, displaying aberrant karyotype, from centers belonging to Spanish Cooperative Group for Hematological Cytogenetics....
Histologic transformation of low-grade B-cell lymphoma to diffuse large is associated with poor prognosis. Although plasma cell differentiation common in these lymphomas, an overt plasmablastic (PBL-T) has been only rarely reported. We report 6 cases PBL-T occurring 3 chronic lymphocytic leukemias (CLL) and follicular lymphomas. Five patients were men, the mean age was 65 years (range, 52 72 y). None them had history immunodeficiency. In occurred 34 85 months after initial diagnosis, it...
Abstract: Background. Nephropathy associated with antiphospholipid antibodies (aPL) has been proposed as a risk factor of worse renal prognosis in patients systemic lupus erythematosus (SLE). The purpose the current study was to evaluate prevalence aPL-associated nephropathy (aPLN) among nephritis and describe their functional outcome. Methods. A total 79 biopsies from 77 followed at Hospital Clinic, Spain were analysed. Each biopsy evaluated by pathologist who blinded aPL status. Thrombotic...
We evaluated the diagnostic utility of simultaneous determination 5 tumor markers, CEA, CA 125, 15-3, 19-9 and cytokeratin 19 (CYFRA 21-1), in fluid serum from 101 patients, 52 with pleural effusion (22 malignant) 49 patients ascites (14 malignant). Tumor marker concentrations malignant effusions were significantly higher than those obtained benign fluids or serum. However, there are two types markers: released/secreted by normal mesothelia such as 125 (higher levels serum)...
Purkinje cells were examined in three familial cases of olivopontocerebellar atrophy (OPCA) by means the Golgi method, and neurofilament calcium-binding protein immunocytochemistry. Reduced dendritic arborizations, as seen with different techniques, early formation axonal spheroids, abnormal accumulation phosphorylated epitopes dendrites, somata together limited proximal spine-like protrusions main changes cells. These lesions are unlikely to be consequence anterograde degeneration secondary...
Pleural effusions present a diagnostic challenge. Approximately 20% are associated with cancer and some 50% require invasive procedures to perform diagnosis. Determination of tumour markers may help identify patients malignant effusions. Two strategies used obtain high specificity in the differential diagnosis pleural effusions: a) cut-off, b) fluid/serum (F/S) ratio low cut-off. The aim this study is compare these two establish whether identification possible false positives using benign...
The objective of the present study is to determine prognostic value clinical variables and biomarkers in patients with advanced stages NSCLC establish a classification these patients.For 135 we determined their levels CEA, CA 125, CYFRA 21-1, albumin, LDH, erythrosedimentation leukocytes.Multivariate analysis identified PS (ECOG) >1, metastases, no anti-neoplastic treatment, 125 >35 U/mL, 21-1 >3.3 ng/mL leukocytes >10'000/µL, as independent factors for survival. Patients were classified...
The utility of tumour markers (TM) in the differential diagnosis cancer serous effusion (fluid (FE)) has been subject controversy. aim this study was to prospectively validate our previous and assess whether addition adenosine deaminase (ADA), C-reactive protein (CRP) or percentage polymorphonuclear cells (%PN) allows identification false positives. In study, carcinoembryonic antigen, antigen 15-3, 19-9, ADA, CRP %PN FE were determined 347 patients with 391 effusions. Effusions considered as...
Chromophobe renal cell carcinoma is an unusual variant of that has less aggressive behavior than clear carcinomas. There are few documented cases metastases, none which occurred in the thyroid gland. A case presented chromophobe metastatic to eight years after right nephrectomy, suspected by FNA-biopsy and confirmed histologically. Although metastases rare, they may also present thyroid, even many primary tumor diagnosis, just like Even though FNA cytology distinctive features, context it...
Background/Aim: Approximately 20% of pleural effusions are associated with cancer; about 50% require invasive procedures to perform diagnosis. Determination the concentration soluble cytokeratin 19-fragments (CYFRA21-1) may help identify patients malignant effusions. However, pathologies other than cancer can increase its concentration. The identification these possible false positives routine tests CRP, ADA, % polymorphonuclear cells (PN) improve diagnostic accuracy. This study aimed...
Background and objective Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting need for predictive biomarkers. We sought a signature NAC integrating clinical score, taxonomic subtype, gene expression. Material methods From 1994 2014, pre-treatment tumor...
Background/Aim: There are two strategies for the interpretation of tumor markers (TM) in fluid effusions: i) high cut-off and ii) fluid/serum ratio (F/S) low cut-off. The objective this study is to compare these determine whether diagnostic accuracy improves by identification possible false positives using Adenosine deaminase (ADA), C reactive protein (CRP) % polymorphonuclear cells (%PN). Patients Methods: We studied 157 ascitic fluids, 74 which were malignant. ADA, CRP %PN determined...
Chromophobe renal cell carcinoma is an unusual variant of that has less aggressive behavior than clear carcinomas. There are few documented cases metastases, none which occurred in the thyroid gland. A case presented chromophobe metastatic to eight years after right nephrectomy, suspected by FNA-biopsy and confirmed histologically. Although metastases rare, they may also present thyroid, even many primary tumor diagnosis, just like Even though FNA cytology distinctive features, context it...