A5044502110- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Neuropeptides and Animal Physiology
- Infectious Diseases and Tuberculosis
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Antimicrobial Resistance in Staphylococcus
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Hemodynamic Monitoring and Therapy
- COVID-19 and healthcare impacts
- Inflammatory Biomarkers in Disease Prognosis
Campus Bio Medico University Hospital
2022-2024
Università Campus Bio-Medico
2014-2023
Associazione Italiana Di Oncologia Medica
2000
Abstract There is concern about a new coronavirus, the 2019-nCoV, as global public health threat. In this article, we provide preliminary evolutionary and molecular epidemiological analysis of virus. A phylogenetic tree has been built using 15 available whole genome sequence 2019-nCoV 12 sequences highly similar in gene bank (5 from SARS, 2 MERS 5 Bat SARS-like Coronavirus). FUBAR shows that Nucleocapsid Spike Glycoprotein some sites under positive pressure while homology modelling helped to...
Rapid diagnosis of bacterial infections is crucial for adequate antibiotic treatment. Serum molecules such as Procalcitonin ( PCT ) have been used biomarkers infection. Recently, the mid‐regional pro‐Adrenomedullin MR ‐pro ADM has evaluated in combination with sepsis diagnosis. The diagnostic role and both localized together their contribution to effective therapy evaluated. One hundred eighty‐two patients infection enrolled: were measured at admission (T = 0), 12–24 h 1) third or fifth day...
ABSTRACT Purpose: The third Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as an organ dysfunction consequent to infection. A Sequential Organ Failure Assessment (SOFA) score at least 2 identifies sepsis. In this study, procalcitonin (PCT) midregional pro-adrenomedullin (MR-proADM) were evaluated along with SOFA quick (qSOFA) scores in patients or septic shock. Methods: total of 109 50 noninfectious disease admitted the Department Internal Medicine General...
Abstract Endothelial barrier (EB) breaching is a frequent event during inflammation, and it followed by the rapid recovery of microvascular integrity. The molecular mechanisms EB are poorly understood. Triggering MHC molecules migrating T-cells minimal signal capable inducing endothelial contraction transient leakage. Using this model, we show that requires CD31 receptor-induced, robust glycolytic response sustaining junction re-annealing. Mechanistically, involves src-homology phosphatase...
Background and Objectives: The aim of this study was to evaluate the diagnostic accuracy prognostic value neutrophil-to-lymphocyte (NLR) platelet-to-lymphocyte (PLR) ratios compare them with other biomarkers clinical scores sepsis outside intensive care unit. Materials methods: In retrospective study, 251 patients 126 infection than were enrolled. NLR PLR calculated as ratio between absolute values neutrophils, lymphocytes, platelets by complete blood counts performed on whole Sysmex XE-9000...
Abstract Early diagnosis and treatment significantly reduce sepsis mortality. Currently, no gold standard has been yet established to diagnose outside the ICU. The aim of study was evaluate diagnostic accuracy defined by SIRS Criteria 1991, Second Consensus Conference 2001, modified 2001 (obtaining SOFA score), Third 2016, in addition dosage Procalcitonin (PCT) MR-pro-Adrenomedullin (MR-proADM). In this prospective study, 209 consecutive patients with clinical were enrolled (May 2014–June...
The widespread endothelial damage due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead a disruption of the adrenomedullin (ADM) system responsible for vascular leakage, increased inflammatory status, and microvascular alteration with multi-organs dysfunction. aim this study was evaluate role mid-regional proadrenomedullin (MR-proADM) as marker SARS-CoV2 related damage, clinically identified by organs disease severity mortality. Patients SARS-CoV-2 infection has been...
Postsurgical infections represent an important cause of morbidity after abdominal surgery. The microbiological diagnosis is not achieved in at least 30% culture with consequent worsening patient outcome. In this study, procalcitonin measurement, during the first 3 days surgery, has been evaluated for early postsurgical infection. Ninety consecutive patients subjected to major surgery University Campus Bio-Medico Rome, have included. PCT concentrations were measured by time-resolved amplified...
// Daniele Santini 1 , Raffaele Ratta 2 Francesco Pantano Delia De Lisi Marco Maruzzo 3 Luca Galli 4,6 Elisa Biasco 4 Azzurra Farnesi Sebastiano Buti 5 Cora Nanette Sternberg 6 Linda Cerbone Giuseppe Di Lorenzo 7 Silvia Spoto 8 Michelle Sterpi Ugo Giorgi 9 Rossana Berardi 10 Mariangela Torniai Andrea Camerini 11 Massari 12 Procopio and Tonini Campus Bio-Medico University of Rome, Department Medical Oncology, Italy Fondazione IRCCS, Istituto Nazionale dei Tumori, Oncology Unit 1, Milan,...
Background: Acute heart failure (AHF) is a major cause of hospitalization and mortality worldwide. Early accurate diagnosis, as well effective risk stratification, are essential for optimizing clinical management improving patient outcomes. In this context, biomarkers have gained increasing interest in recent years they can provide important diagnostic prognostic information patients with AHF. Aim Methods: The primary objective the present study was to compare levels N-terminal pro-B-type...
Enterobacter microorganisms cause important bacterial infections in humans. Recently, carbapenem resistant isolates carrying the blaKPC gene were described and their clonal transmission different nosocomial outbreaks reported. In this study, relative numbers of species, antimicrobial susceptibility along 3 years observation identification ability two most common MALDI-TOF platforms evaluated. A clustering analysis was performed to identify changes microbial population within environment....
Abstract The introduction of trained sniffer dogs for COVID‐19 detection could be an opportunity, as previously described other diseases. Dogs to detect volatile organic compounds (VOCs), the whiff COVID‐19. involved in study were three, one male and two females from different breeds, Black German Shepherd, Dutch Shepherd. training was performed using sweat samples SARS‐CoV2 positive patients SARS‐Cov2 free admitted at University Hospital Campus Bio‐medico Rome. Gauze with collected a glass...
Abstract The appearance of emerging variants SARS‐CoV‐2 carrying mutations into the spike protein has recently raised concern with respect to tracking their transmission and mitigating impact in evolving pandemic across countries. AY.4.2, a detected Delta variant sublineage, is considered new under investigation (VUI) as it carries specific genetic signatures present protein, called Y145H A222V. Here, using genomic epidemiology, we provide first preliminary insight regarding circulation this...
Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in the epidemiological surveillance multi-drug nosocomial pathogens. Between January 2012 February 2013, twenty-one K. pneumoniae strains, were collected from patients hospitalized among different wards University Hospital Campus Bio-Medico....