A5060077478- Advancements in Transdermal Drug Delivery
- Advanced machining processes and optimization
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Advanced Measurement and Metrology Techniques
- Advanced Surface Polishing Techniques
- Advanced Machining and Optimization Techniques
- Toxin Mechanisms and Immunotoxins
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Adhesion, Friction, and Surface Interactions
- Additive Manufacturing and 3D Printing Technologies
- Advanced Biosensing Techniques and Applications
- Manufacturing Process and Optimization
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Dynamics and Control of Mechanical Systems
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Analytical Methods in Pharmaceuticals
- Pain Mechanisms and Treatments
- Healthcare Quality and Satisfaction
University of Pittsburgh
2019-2024
Kayseri Eğitim ve Araştırma Hastanesi
2023
Carnegie Mellon University
2013-2020
BackgroundCoronaviruses pose a serious threat to global health as evidenced by Severe Acute Respiratory Syndrome (SARS), Middle East (MERS), and COVID-19. SARS Coronavirus (SARS-CoV), MERS (MERS-CoV), the novel coronavirus, previously dubbed 2019-nCoV, now officially named SARS-CoV-2, are causative agents of SARS, MERS, COVID-19 disease outbreaks, respectively. Safe vaccines that rapidly induce potent long-lasting virus-specific immune responses against these infectious urgently needed. The...
Additively manufactured objects often exhibit directional dependencies in their structure due to the layered nature of printing process. While this dependency has a significant impact on object's functional performance, problem finding best build orientation maximize structural robustness remains largely unsolved. We introduce an optimization algorithm that addresses issue by identifying maximizes factor safety (FS) input object under prescribed loading and boundary configurations. First, we...
Optimal vaccines are needed for sustained suppression of SARS-CoV-2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene S1 subunit antigen (Ad5.SARS-CoV-2-S1) COVID-19 immunization evaluated its immunogenicity in mice. A single with Ad5.SARS-CoV-2-S1 via S.C. injection or I.N delivery induced robust antibody cellular immune responses. Vaccination elicited significant S1-specific IgG, IgG1, IgG2a endpoint titers as early 2 weeks,...
The effect of polymer modification on the deformation characteristics and processibility particle assembly structures is analyzed as a function size degree polymerization surface-tethered chains. A pronounced increase fracture toughness (by approximately one order magnitude) observed exceeds threshold value that increases with size. interpreted being related to transition tethered chains from stretched-to-relaxed conformation (and associated entanglement chains) agrees predictions scaling...
Particles synthesized from biodegradable polymers hold great potential as controlled drug delivery systems. Continuous flow platforms based on microfluidics offer attractive advantages over conventional batch-emulsification techniques for the scalable fabrication of drug-loaded particles with physicochemical properties. However, widespread utilization microfluidic technologies manufacturing has been hindered largely by lack practical guidelines toward cost-effective development and reliable...
This paper presents an experimental investigation on micromachinability characteristics of Poly(methyl methacrylate) (PMMA, with the common trade names Acrylic® or Plexiglass®) when using single-crystal diamond micro-endmills towards enabling rapid, accurate, and reproducible fabrication PMMA parts for a broad range applications. An study full factorial design is conducted straight micro-endmill diameter 450 μm. A set full-immersion micromilling tests are performed within custom-made...
Fentanyl-terminated polyesters provide linear release of therapeutics with an effective antinociceptive effect <italic>in vivo</italic>.
BackgroundAllergic contact dermatitis (CD) is a chronic inflammatory skin disease caused by type 1 biased adaptive immunity for which there an unmet need antigen (Ag)-specific immunotherapies. Exposure to sensitizers stimulates secretion of the proinflammatory neuropeptides substance P and hemokinin 1, signal via neurokinin-1 receptor (NK1R) promote innate immune responses CD. Accordingly, mice lacking NK1R develop impaired Nonetheless, role therapeutic opportunities targeting in CD remain...