A5007994621- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Redox biology and oxidative stress
- Pneumonia and Respiratory Infections
- Cancer, Stress, Anesthesia, and Immune Response
- Mast cells and histamine
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Pneumocystis jirovecii pneumonia detection and treatment
- Skin Protection and Aging
- Advanced Biosensing Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Viral gastroenteritis research and epidemiology
- HIV/AIDS oral health manifestations
University of South Carolina
2025
University of Pittsburgh
2015-2024
UNSW Sydney
2010-2023
BackgroundCoronaviruses pose a serious threat to global health as evidenced by Severe Acute Respiratory Syndrome (SARS), Middle East (MERS), and COVID-19. SARS Coronavirus (SARS-CoV), MERS (MERS-CoV), the novel coronavirus, previously dubbed 2019-nCoV, now officially named SARS-CoV-2, are causative agents of SARS, MERS, COVID-19 disease outbreaks, respectively. Safe vaccines that rapidly induce potent long-lasting virus-specific immune responses against these infectious urgently needed. The...
Optimal vaccines are needed for sustained suppression of SARS-CoV-2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene S1 subunit antigen (Ad5.SARS-CoV-2-S1) COVID-19 immunization evaluated its immunogenicity in mice. A single with Ad5.SARS-CoV-2-S1 via S.C. injection or I.N delivery induced robust antibody cellular immune responses. Vaccination elicited significant S1-specific IgG, IgG1, IgG2a endpoint titers as early 2 weeks,...
Pneumococcal disease is a serious bacterial infection, particularly for high-risk groups such as infants, adults 65 and older, individuals with certain conditions; however, vaccination rates remain low. Pharmacists are often visited more frequently than primary care physicians therefore in unique position to increase pneumococcal rates. This study aims identify barriers assess pharmacists' knowledge of vaccines community pharmacy setting. A cross-sectional was conducted, surveying 124...
Peripheral glia, specifically the Schwann cells (SCs), have been implicated in formation of tumor microenvironment (TME) and cancer progression. However, vivo ex analyses how cancers reprogram SC functions different organs tumor-bearing mice are lacking. We generated Plp1-CreERT/tdTomato which harbor fluorescently labeled myelinated non-myelin forming SCs. show that this model enables isolation SCs with high purity from skin multiple other organs. used to study phenotypic functional...
Abstract The development of effective cancer vaccines remains an urgent, but as yet unmet, clinical need. This deficiency is in part due to incomplete understanding how best invoke dendritic cells (DC) that are crucial for the induction tumor-specific CD8+ T capable mediating durable protective immunity. In this regard, elevated expression transcription factor X box–binding protein 1 (XBP1) DC appears play a decisive role promoting ability cross-present Ags therapeutic setting. Delivery DNA...
Reactions between nitric oxide (NO), nitrite (NO2-), and unsaturated fatty acids give rise to electrophilic nitro-fatty (NO2 -FAs), such as nitro oleic acid (OA-NO2 ) linoleic (LNO2 ). Endogenous (EFAs) mediate anti-inflammatory responses by modulating metabolic inflammatory signal transduction reactions. Hence, there is considerable interest in employing NO2 -FAs other EFAs for the prevention treatment of disorders. Thus, we sought determine whether OA-NO2 , an exemplary acid, has capacity...
The progressive tumor microenvironment (TME) coordinately supports cell expansion and metastasis, while it antagonizes the survival (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic strategies that can transform TME into pro-inflammatory niche recruits sustains protective immune populations. While intravenous treatment with tumor-primed CD4+ cells combined intraperitoneal delivery agonist anti-glucocorticoid-induced TNF receptor...
Background and Objectives Bacterial pneumonia still contributes to morbidity/mortality in HIV infection despite effective combination antiretroviral therapy (cART). Evaluation of Subcutaneous Interleukin-2 a Randomized International Trial (ESPRIT), trial intermittent recombinant interleukin-2 (rIL-2) with cART vs. alone (control arm) HIV-infected adults CD4 counts ≥300 cells/μL, offered the opportunity explore associations between bacterial rIL-2, cytokine that increases risk some...
Sustainable global immunization campaigns against COVID-19 and other emerging infectious diseases require effective, broadly deployable vaccines. Here, we report a dissolvable microarray patch (MAP) SARS-CoV-2 vaccine that targets the immunoresponsive skin microenvironment, enabling efficacious needle-free immunization. Multicomponent MAPs delivering both S1 subunit antigen TLR3 agonist Poly(I:C) induce robust antibody cellular immune responses systemically in respiratory mucosa. MAP...
Abstract Chronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide and HIV an independent risk factor for development COPD. However, etiology this increased means to identify persons with (PWH) at highest COPD have remained elusive. Biomarkers may reveal etiologic pathways allow better stratification. We performed a matched case:control study PWH in Strategic Timing Antiretoviral Treatment (START) substudy. Cases had rapid lung function decline (> 40...
Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common human malignancy worldwide. Current therapies, including surgical excision, are associated with significant morbidities and considerable expense. Multiple efforts now underway to develop novel therapies that effective, durable, safe, cost-effective, patient-friendly. Here, we report ongoing a localized dissolvable microneedle array patch (MAP) based therapy for cSCC. Our approach on hypothesis delivery of an...
Epidermal keratinocytes, immune cells and sensory nerves all contribute to balance skin homeostasis. Keratinocyte release of growth factors, neuromodulators activators is particularly important because each can evoke local (skin) systemic (i.e., neural) responses that initiate exacerbate pathophysiology. From studies neural we hypothesized neurturin (Nrtn), a member the glial cell line-derived neurotrophic factor (GDNF) family expressed in skin, has particular importance this process. Here...
Background Despite the remarkable benefits associated with interventional treatment of melanomas (and other solid cancers) immune checkpoint and Braf inhibitors (Brafi), most patients ultimately progress on therapy. The presence multifocal/disseminated disease in increases their mortality risk. Hence, development novel strategies to effectively treat that are resistant anti-PD1 mAb (αPD1) and/or Brafi, particularly those remains a major unmet clinical need. Methods Mice developing...
Abstract Despite the remarkable treatment benefits associated with interventional checkpoint PD1 blockade in cancer, most patients ultimately progress on therapy. Revealing mechanisms underlying tumors responsive to is critical identifying biomarkers for predicting responses therapy and developing novel combined therapeutic regimens their broad use clinic. In a clinically reflective mouse model of spontaneous metastatic breast carcinoma, effective durable dependent systemic immunity...