A5016160349- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Diagnosis and treatment of tuberculosis
- Insect Resistance and Genetics
- Hydrogen Storage and Materials
- Infant Nutrition and Health
- Entomopathogenic Microorganisms in Pest Control
- AI in cancer detection
- Plant Disease Resistance and Genetics
- Insect and Pesticide Research
- Extracellular vesicles in disease
- Mosquito-borne diseases and control
- Parasitic infections in humans and animals
- Wheat and Barley Genetics and Pathology
- Vector-borne infectious diseases
- Insect Pest Control Strategies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Pancreatitis Pathology and Treatment
- Cutaneous Melanoma Detection and Management
- Advancements in Transdermal Drug Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Mycotoxins in Agriculture and Food
University of Pittsburgh
2022
University of Maryland, Baltimore
2021
University of Calgary
2017-2019
Madan Mohan Malaviya University of Technology
2018
Technion – Israel Institute of Technology
2016-2017
Deen Dayal Upadhyaya Gorakhpur University
2015
Ben-Gurion University of the Negev
2013-2014
Indian Agricultural Statistics Research Institute
2007
Abstract Extracellular vesicles are thought to facilitate pathogen transmission from arthropods humans and other animals. Here, we reveal that spreading the mammalian host is multifaceted. Ixodes scapularis enable tick feeding promote infection of mildly virulent rickettsial agent Anaplasma phagocytophilum through SNARE proteins Vamp33 Synaptobrevin 2 dendritic epidermal T cells. However, extracellular Dermacentor andersoni mitigate microbial caused by lethal Francisella tularensis ....
Entamoeba histolytica is an obligate protozoan parasite of humans, and amebiasis, infectious disease which targets the intestine and/or liver, second most common cause human death due to a after malaria. Although amebiasis usually asymptomatic, E. has potent pathogenic potential. During host infection, exposed reactive oxygen species that are produced released by cells innate immune system at site infection. The ability survive oxidative stress (OS) essential for successful invasion host....
Entamoeba histolytica is a gastrointestinal protozoan parasite that causes amebiasis, disease which has worldwide distribution with substantial morbidity and mortality. Nitrosative stress, generated by innate immune cells, one of the various environmental challenges E. encounters during its life cycle. Although effects nitric oxide (NO) on regulation gene expression in this have been previously investigated, our knowledge S-nitrosylated proteins E.histolytica lacking. In order to fill gap,...
Abstract Adaptation of the Entamoeba histolytica parasite to toxic levels nitric oxide (NO) that are produced by phagocytes may be essential for establishment chronic amebiasis and parasite’s survival in its host. In order obtain insight into mechanism E. ’s adaptation NO, trophozoites were progressively adapted increasing concentrations NO donor drug, S-nitrosoglutathione (GSNO) up a concentration 110 μM. The transcriptome (NAT) was investigated RNA sequencing (RNA-seq). N-acetyl ornithine...
We have recently reported that Entamoeba histolytica trophozoites can adapt to toxic levels of the nitric oxide (NO) donor, S-nitrosoglutathione (GSNO). Even if consequences this adaptation on modulation gene expression in NO-adapted (NAT) been previously explored, insight S-nitrosylated (SNO) proteins NAT is missing. Our study aims fill knowledge gap by performing a screening SNO NAT. Employing resin-assisted capture (RAC), we identified 242 putative with key functions calcium binding,...
The intestinal protozoan parasite Entamoeba histolytica (Eh) causes amebiasis associated with severe diarrhea and/or liver abscess. Eh pathogenesis is multifactorial requiring both virulent molecules and host-induced innate immune responses. Eh-induced host pro-inflammatory responses plays a critical role in disease by causing damage to tissues allowing parasites access systemic sites. cyclooxygenase (EhCox) derived prostaglandin E2 stimulates the chemokine IL-8 from mucosal epithelial cells...
Melanoma is less known than some different kinds of skin tumor; however, it most probably developing and spreading. tumor detection at a beginning period vital for productive treatment. Image processing playing an imperative role in therapeutic domain. The means associated with this examination are gathering dermoscopy picture database, preprocessing, segmentation utilizing thresholding, measurable feature extraction using GLCM, wavelet, Tamura. classification includes SVM, KNN, decision...
Abstract BACKGROUND Conventional methods often fail to control the flatheaded borers Capnodis spp., major pests of stone fruit trees; larvae are protected from insecticides and predation because they feed deep in roots. A potential solution is transgenic trees producing their roots toxic compounds such as Cry proteins Bacillus thuringiensis ( Bt ) . RESULTS Toxicities against were demonstrated by exploiting a recently designed artificial larval diet an available collection field isolated An...
Sustainable global immunization campaigns against COVID-19 and other emerging infectious diseases require effective, broadly deployable vaccines. Here, we report a dissolvable microarray patch (MAP) SARS-CoV-2 vaccine that targets the immunoresponsive skin microenvironment, enabling efficacious needle-free immunization. Multicomponent MAPs delivering both S1 subunit antigen TLR3 agonist Poly(I:C) induce robust antibody cellular immune responses systemically in respiratory mucosa. MAP...