Paul J. Gagne

ORCID: 0000-0002-8809-0252
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About
Contact & Profiles
Research Areas
  • Venous Thromboembolism Diagnosis and Management
  • Diagnosis and Treatment of Venous Diseases
  • Central Venous Catheters and Hemodialysis
  • Cerebrovascular and Carotid Artery Diseases
  • Vascular Procedures and Complications
  • Aortic aneurysm repair treatments
  • Cardiovascular Health and Disease Prevention
  • Intracranial Aneurysms: Treatment and Complications
  • Peripheral Artery Disease Management
  • Protease and Inhibitor Mechanisms
  • Acute Ischemic Stroke Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Oropharyngeal Anatomy and Pathologies
  • Angiogenesis and VEGF in Cancer
  • Blood Coagulation and Thrombosis Mechanisms
  • Vascular Malformations and Hemangiomas
  • Aortic Disease and Treatment Approaches
  • Cardiac Imaging and Diagnostics
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Diabetic Foot Ulcer Assessment and Management
  • Moyamoya disease diagnosis and treatment
  • Vascular Tumors and Angiosarcomas
  • Infectious Aortic and Vascular Conditions
  • Abdominal vascular conditions and treatments
  • Peptidase Inhibition and Analysis

Breakthrough
2017-2019

Norwalk Hospital
2011-2018

Western University of Health Sciences
2015

Columbia University Irving Medical Center
1991-2008

New York University
1993-2008

Naval Medical Center Portsmouth
1995-2003

Heinrich Heine University Düsseldorf
2002

Düsseldorf University Hospital
2002

University Medical Center
2002

University of Arkansas for Medical Sciences
1994-2000

Background— The recent discovery of circulating endothelial progenitor cells (EPCs) has altered our understanding new blood vessel growth such as occurs during collateral formation. Because diabetic complications occur in conditions which EPC contributions have been demonstrated, dysfunction may be important their pathophysiology. Methods and Results— EPCs were isolated from human type II diabetics (n=20) age-matched control subjects (n=20). Proliferation relative to was decreased by 48% ( P...

10.1161/01.cir.0000039526.42991.93 article EN Circulation 2002-11-25

In the present study, we evaluated safety and effectiveness of Zilver Vena venous stent in treatment patients with symptomatic iliofemoral outflow obstruction.The VIVO clinical study was a prospective, nonrandomized, multicenter that enrolled obstruction one segment. Included were Clinical, Etiological, Anatomical, Pathophysiological (CEAP) classification ≥3 or Venous Clinical Severity Score (VCSS) pain score ≥2. All received self-expanding (Zilver stent; Cook Ireland Ltd, Limerick,...

10.1016/j.jvsv.2022.12.066 article EN publisher-specific-oa Journal of Vascular Surgery Venous and Lymphatic Disorders 2023-01-13

Purpose To report 36-month outcomes and subgroup analysis of the ABRE Study evaluating safety effectiveness Abre venous self-expanding stent system for treatment symptomatic iliofemoral outflow obstruction disease. Methods The was a prospective, multicenter, non-randomized study that enrolled implanted stents in 200 participants (mean age 51.5±15.9 years 66.5% women) with at 24 global sites. Outcomes assessed through 36 months included patency, major adverse events, migration, fracture,...

10.1016/j.jvir.2024.01.030 article EN cc-by Journal of Vascular and Interventional Radiology 2024-02-08

To report our initial experience implementing a noncontrast-enhanced electrocardiograph (ECG) gated fast spin echo magnetic resonance angiography (MRA) technique for assessment of the calf arteries.Noncontrast MRA images 36 clinical patients examined over 6-month period were evaluated by two radiologists length and degree stenosis arterial segments. Diagnostic confidence in was also recorded. The reference standard consensus reading both using noncontrast combined with gadolinium-enhanced...

10.1002/jmri.21416 article EN Journal of Magnetic Resonance Imaging 2008-06-25

Background: Chronic venous insufficiency is characterized by inadequate return from the lower extremities, which may arise intravenous obstruction after deep vein thrombosis or extrinsic compression. The purpose of this study was to determine safety and effectiveness a dedicated endovenous stent for symptomatic iliofemoral obstruction. Methods: VIRTUS trial (VIRTUS Safety Efficacy Veniti Vici Venous Stent System [Veniti, Inc] When Used Treat Clinically Significant Non-Malignant Obstruction...

10.1161/circinterventions.119.008268 article EN Circulation Cardiovascular Interventions 2019-12-01

To report 3-year outcomes from a prospective, multicenter, nonrandomized, single-arm study designed to assess the safety and effectiveness of Zilver Vena Venous Stent for treatment symptomatic iliofemoral venous outflow obstruction. The VIVO included patients with obstruction 1 segment (ie, limb), characterized by Clinical, Etiological, Anatomic, Pathophysiology (CEAP) clinical classification ≥3 or Clinical Severity Score (VCSS) pain ≥2. Patients were retrospectively grouped based on...

10.1016/j.jvir.2024.02.025 article EN cc-by Journal of Vascular and Interventional Radiology 2024-03-12

We examined the perioperative course and long-term fate of individuals who required reoperation for recurrent carotid artery disease.The records 2289 patients undergoing 2961 consecutive operations during a 22-year period were reviewed. Forty-two (1.8%) underwent reoperations studied. Forty-seven redo reconstructions performed on these 42 neurologic symptoms or asymptomatic high-grade stenosis. Long-term follow-up was obtained 41 (mean 54 months; range 9 to 202 months).The forty-seven...

10.1016/0741-5214(93)90554-y article EN cc-by-nc-nd Journal of Vascular Surgery 1993-12-01

Objective To evaluate the efficacy and safety of an investigational fibrin sealant (FS) in a randomized prospective, partially blinded, controlled, multicenter trial. Summary Background Data Upper extremity vascular access surgery using polytetrafluorethylene (PTFE) graft placement for dialysis was chosen as reproducible, clinically relevant model evaluating usefulness FS. The FS consisted pooled human fibrinogen (60 mg/mL) thrombin (500 NIH U/mL). Time to hemostasis measured, adverse events...

10.1097/01.sla.0000071565.02994.da article EN Annals of Surgery 2003-06-01

Objective Interventionalists have noted significant venous luminal gain with nitinol stents although post-placement lumen shape differed from the circular observed elgiloy stents. The goal of this study was to determine characteristics a stented vein that correspond clinical outcomes, and identify metrics might be relevant for stent design by assessing aspect ratio (AR), diameter (LD), area (LA), (symmetry eccentricity) post-implant. Methods This post-hoc analysis evaluated patients VIVO US...

10.1177/15385744251321900 article EN Vascular and Endovascular Surgery 2025-02-18
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