A5103161167- Muscle activation and electromyography studies
- Motor Control and Adaptation
- Children's Physical and Motor Development
- Plant Molecular Biology Research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sports Performance and Training
- Neuroscience and Neural Engineering
- Exercise and Physiological Responses
- Transcranial Magnetic Stimulation Studies
- Hormonal and reproductive studies
- Plant Gene Expression Analysis
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Muscle Physiology and Disorders
- Plant Stress Responses and Tolerance
- Immune responses and vaccinations
- Diabetic Foot Ulcer Assessment and Management
- Plant Genetic and Mutation Studies
- Myofascial pain diagnosis and treatment
- Glioma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Orthopedic Infections and Treatments
University of Nottingham
2020-2024
Versus Arthritis
2020-2024
National Institute for Health Research
2021-2024
Nottingham Biomedical Research Centre
2021-2024
Royal Derby Hospital
2024
Chengdu Sport University
2024
Beijing Forestry University
2018-2021
Jining First People's Hospital
2021
Huashan Hospital
2020
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2020
Despite males typically exhibiting greater muscle strength and fatigability than females, it remains unclear if there are sex-based differences in neuromuscular recruitment strategies e.g. modulation of motor unit firing rate (MU FR) at normalized forces during progressive increases force.The study includes 29 healthy male 31 female participants (18-35 years). Intramuscular electromyography (iEMG) was used to record individual potentials (MUPs) near-fibre MUPs from the vastus lateralis (VL)...
Abstract Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents (PIC) and the level common synaptic inputs motoneurons influence neuromuscular function. However, these have not yet been described in aged human quadriceps. High-density surface electromyography (HDsEMG) signals were collected from vastus lateralis 15 young (mean ± SD, 23 5 y) older (67 9 men during submaximal...
Females typically live longer than males but, paradoxically, spend a greater number of later years in poorer health. The neuromuscular system is critical component the progression to frailty, and motor unit (MU) characteristics differ by sex healthy young individuals may adapt ageing sex-specific manner due divergent hormonal profiles. purpose this study was investigate differences vastus lateralis (VL) MU structure function early late elderly humans. Intramuscular electromyography signals...
Introduction Resistance exercise (RE) enhances functionality in older adults and has proven effective as a means of cross-education scenarios unilateral disuse. However, the extent to which demonstrate cross-limb transfer at motor unit (MU) level following single bout RE is unclear. Methods Thirteen healthy (> 60 years; 5 females) underwent bilateral neuromuscular assessments pre- post- consisting 3-4 sets 8-12 repetitions leg extension dominant (exercise) leg, 75% 1 repetition maximum,...
Estrogen and progesterone are the primary female sex hormones have net excitatory inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across menstrual cycle has led to several lines of research in relation neuromuscular function performance; however evidence from animal cell culture models yet be demonstrated human motor units coupled with quantification circulating hormones. Intramuscular electromyography was used record unit potentials corresponding potential...
Abstract Force output of muscle is partly mediated by the adjustment motor unit (MU) firing rate (FR). Disparities in MU features response to fatigue may be influenced contraction type, as concentric (CON) and eccentric (ECC) contractions demand variable amounts neural input, which alters fatigue. This study aimed determine effects following CON ECC loading on vastus lateralis (VL). High‐density surface (HD‐sEMG) intramuscular (iEMG) electromyography were used record potentials (MUPs) from...
Radiomics has potential advantages in the noninvasive histopathological and molecular diagnosis of gliomas. We aimed to develop a novel image signature (IS)-based radiomics model achieve multilayered preoperative prognostic stratification Herein, we established three separate case cohorts, consisting 655 glioma patients, carried out retrospective study. Image clinical data cohorts were used for training (N = 188), cross-validation 411), independent testing 56) IS model. All tumors segmented...
Abstract Background Females typically have a longer lifespan than males which is not matched by an improved healthspan, with older females having higher rates of frailty, characteristic sex specific degradation the neuromuscular system. Several motor unit (MU) characteristics show sex-specific behaviour during mid-level contractions in healthy younger people, highlighting potential influence hormonal differences that may be augmented age. The purpose this study was to investigate physical...
Picea wilsonii is widely used for a forestation and landscaping in China. However, the molecular mechanisms underlying abiotic stress tolerance this species remain elusive. In study, we examined transcriptomic changes induced by drought salt 8-week-old seedlings of P. via RNA-Seq analysis; grown under normal conditions (without stress) served as control. Approximately 36.26 Gb transcriptome data were obtained from three treatments. A total 4171 (2579 up-regulated 1732 down-regulated) 3438...
Abstract Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents and the level common synaptic inputs motoneurons influence neuromuscular function. However, these have not yet been described in aged human quadriceps. High density surface electromyography (HDsEMG) signals were collected from vastus lateralis 15 young (mean±SD, 23 ± 5 y) older (67 9 men during submaximal...
Abstract Aim Despite men exhibiting greater muscle strength and fatigibility than women, it remains unclear if there are sex-based differences in recruitment strategies e.g. motor unit (MU) modulation of firing rate (FR) at normalised forces during progressive increases force. Methods Twenty-nine healthy male thirty-one female participants (18-35 years) were studied. Intramuscular electromyography was used to record individual potentials (MUPs) near fibre MUPs from the vastus lateralis (VL)...
Abstract Patients with metastatic breast cancer have a dismal 5-year survival rate of only 24%. Chemoresistance is another contributor to the high mortality advanced cancer. The RNA-binding protein, Hu antigen R (HuR), overexpressed at all stages development. Cytoplasmic HuR accumulation correlates high-grade malignancy, poor distant disease-free and serves as prognostic factor for clinical outcome in promotes tumorigenesis by promoting mRNA stability translation proteins implicated...
Abstract Hu antigen R (HuR), a ubiquitous RNA-binding protein (RBP), has been shown to be overexpressed in gastric cancer. Cytoplasmic HuR is reported associated with high stage, distant metastases and unresectability. efficiently regulates cancer-related gene expression by binding AU- U-rich sequences (ARE) the 3’ 5’-untranslated region (UTR) of mRNAs. Id1 (Inhibitor DNA binding) putative oncogene that we previously found was upregulated cancer poor prognosis. mRNA contains several ARE...
Abstract Estrogen and progesterone are the primary female sex hormones have net excitatory inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across menstrual cycle has led to several lines of research in relation neuromuscular function, yet evidence from animal cell culture models be demonstrated human motor units (MU) coupled with quantification circulating hormones. Intramuscular electromyography (iEMG) was applied record MU potentials (MUP) corresponding...
Aims: To identify the factors that has an impact on infected pressure ulcers healing among elder outpatients. Methods: A retrospective study of data from outpatients with ulcer was conducted to may affect their healing. Data between January 1, 2017, and December 31, in a general hospital Shanghai, China, who had assessed using Pressure Ulcer Scale for Healing (PUSH), were abstracted. The following variables examined: demographic characteristics (gender, age, culture background, marriage...
Background Age-related neuromuscular decrements are partly attributed to the gradual decline of circulating sex hormones, accompanied by transition metabolic processes from largely anabolic catabolic, which is further mediated levels physical activity [1, 2]. Administration androgens have been demonstrated positively influence neuroplasticity in animal models [3, 4], acting both centrally and peripherally. However, human data on associations hormone with peripheral motor nerve function...