A5043861812- Hormonal and reproductive studies
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Muscle activation and electromyography studies
- Adrenal and Paraganglionic Tumors
- Frailty in Older Adults
- Cerebral Palsy and Movement Disorders
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Sperm and Testicular Function
- Ovarian function and disorders
- Dialysis and Renal Disease Management
- Exercise and Physiological Responses
- Sodium Intake and Health
- Thermoregulation and physiological responses
- Adrenal Hormones and Disorders
- Bipolar Disorder and Treatment
- Ion channel regulation and function
- Pituitary Gland Disorders and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Diabetes and associated disorders
- HIV-related health complications and treatments
- Pharmacology and Obesity Treatment
- Muscle Physiology and Disorders
- Children's Physical and Motor Development
University of Nicosia
2022
University of Manchester
2016-2021
Manchester Academic Health Science Centre
2017-2019
St Mary's Hospital
2016
Medical University of Białystok
2009
The age-related loss of muscle mass is related to the innervating motor neurons and denervation fibres. Not all denervated fibres are degraded; some may be reinnervated by an adjacent surviving neuron, which expands unit proportional numbers rescued. Enlarged units have larger potentials when measured using electrophysiological techniques. We recorded much in relatively healthy older men compared young men, but with smallest muscles (sarcopenia) had smaller than men. These findings suggest...
Muscle motor unit numbers decrease markedly in old age, while remaining units are enlarged and can have reduced neuromuscular junction transmission stability. However, it is possible that regular intense physical activity throughout life attenuate this remodeling. The aim of study was to compare the number, size, stability tibialis anterior (TA) healthy young older men with those exceptionally active master runners. distribution potential (MUP) size determined from intramuscular...
The evidence concerning the effects of exercise in older age on motor unit (MU) numbers, muscle fibre denervation and reinnervation cycles is inconclusive it remains unknown whether any are dependent type undertaken or localised to highly used muscles. Motor characteristics vastus lateralis (VL) were assessed using surface intramuscular electromyography eighty-five participants, divided into sub groups based (young, old) athletic discipline (control, endurance, power). In a separate study...
Summary Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone ( LH ) are unclear. We describe natural history, risk factors features associated with development biochemical primary hypogonadism PHG , T < 10·5 nmol/l >9·4U/l) in men. Design, Patients Measurements A prospective observational cohort survey 3,369 community‐dwelling men aged 40‐79 years, followed up for 4·3 years. Men were classified as...
Clinical sequelae of androgen deficiency share common features with frailty. Evidence supporting the role androgens in development frailty is limited and conflicting. To determine associations between male reproductive hormones prospective changes status. A 4.3-year cohort study community-dwelling men participating European Male Ageing Study. total 3369 aged 40 to 79 from eight centers. None. Frailty status was determined using index (FI; n = 2278) phenotype (FP; 1980). After adjusting for...
Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe natural history, risk factors and clinical parameters associated development high LH (HLH, >9.4 U/L) in ageing men T (T ≥ 10.5 nmol/L).We conducted a 4.3-year prospective observational study 3369 community-dwelling European aged 40-79 years. Participants were classified as follows: incident (i) HLH (n = 101, 5.2%); persistent (p) 128, 6.6%); reverted (r) 46,...
Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. To determine associations between changes in frailty status. A 4.3-year observational study community-dwelling men participating the European Male Ageing Study. Men (n = 3369) aged 40 to 79 years from eight centers. Frailty status was determined using phenotype (FP; n 2114) index (FI; 2444). Regression models assessed relationships baseline...
<b><i>Background:</i></b> Progressive chronic kidney disease (CKD) inevitably leads to salt and water retention disturbances in the macro-and microcirculation. <b><i>Objectives:</i></b> We hypothesize that dysregulation advanced CKD may be linked inflammation microvascular injury pathways. <b><i>Methods:</i></b> studied 23 stage 5 patients 11 healthy controls (HC). Tissue sodium concentration was assessed using...
Multifrequency bioimpedance spectroscopy (BIS) is an established method for assessing fluid status in chronic kidney disease (CKD). However, the technique lacking predictive value and accuracy. BIS algorithms assume constant tissue resistivity, which may vary with changing ionic sodium concentration (Na+). This introduce significant inaccuracies to outputs. To investigate this, we used 23Na magnetic resonance imaging (MRI) measure Na+ muscle subcutaneous tissues of 10 healthy controls (HC)...
What is the central question of this study? Human frailty characterized by accumulated health complaints, including medical conditions, low physical and psychological function social components. It currently unknown whether condition associated with neuromuscular changes detectable electrophysiology obtained from voluntary involuntary muscle contractions. main finding its importance? A higher likelihood was significantly a smaller size vastus lateralis motor unit potentials during...
To assess ethnic differences in male reproductive hormone levels and to determine whether any are explained by adiposity, insulin resistance (IR) or comorbidities older men.Multi-ethnic cross-sectional observational study.Community dwelling middle-aged elderly men residing the UK aged 40-84 years of South Asian (SA; n = 180), White European (WE; 328) African Caribbean (AC; 166) origin.Measured testosterone (T), calculated free T (cFT), sex hormone-binding globulin LH SA, WE AC along with an...
Anabolic hormones are important factors in maintaining muscle mass for aging men, but their role overall motor unit structure and function is unclear.The objective of this work to determine associations anabolic reproductive hormone levels with characteristics quadriceps older healthy frail men.This an observational cohort study community-dwelling men.Participants included men younger than 65 years.No intervention was performed.Quantitative assessments electromyography-derived potential size...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)