A5003590629- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Advanced Drug Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Nanoparticle-Based Drug Delivery
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Clusterin in disease pathology
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Nanoplatforms for cancer theranostics
Army Medical University
2022-2024
Southwest Hospital
2022-2024
Tianjin Medical University
2019-2021
Second Hospital of Tianjin Medical University
2019-2021
Putian University
2021
Purpose: Metastatic prostate cancer (PCa) has become a major obstacle in the treatment of PCa. The study's purpose is to find biomarkers tumor metastasis by proteomics and enzyme-linked immunosorbent assay (ELISA), design related experiments study its role progress Method: We analyzed serum from primary PCa stage metastatic 12 patients protein using isobaric tags for relative absolute quantitation (iTRAQ). An effective diagnostic model based on validated logistic regression was established....
Background: M2 macrophages can promote the progression of castration-resistant prostate cancer (CRPC), but specific mechanism is still unclear. Therefore, we are preliminarily exploring molecular by which regulate CRPC. Methods: The genes positively correlated with CRPC and most significant differences in GEO32269 dataset were obtained. Database immunofluorescence experiments used to validate localization secreted phosphoprotein 1 (SPP1) localized (PCa), hormone-sensitive (HSPC), tumor...
Chronic bacterial prostatitis usually occurs in men and seriously affects the quality of life patients. The efficacy chronic treatment is limited by difficulty for free drugs (e.g., antibiotics) to penetrate prostate epithelium target inflammatory tissues. advent nanotechnology offers possibility address this issue, such as development targeted nanoparticle delivery strategies that may overcome these important limitations. physicochemical properties nanoparticles, particle size, shape...
Abstract Background Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed clarify role of Human antigen R (HuR) as a therapeutic target for CRPC progression. Methods HuR was knocked out by Cas9 or inhibited HuR-specific inhibitor KH-3 in cell lines mouse xenograft model. The effects inhibition on tumour behaviors signal transduction were examined proliferation, transwell, assays....
The aim of the present study was to explore and verify potential mechanism seminoma progression. Data on 132 RNA‑seq 156 methylation sites from stage II/III I specimens were downloaded Cancer Genome Atlas database. An initial filter |fold‑change| >2 false discovery rate <0.05 used identify differentially expressed genes (DEGs) which associated with differential site genes; these considered candidates for further investigation by survival analysis. Potassium voltage‑gated channel subfamily C...
Abstract Increased proinflammatory cytokines and infiltration of inflammatory cells in the stroma are important pathological features type IIIA chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS-A), interaction between stromal other microenvironment is closely related to process CP/CPPS-A. However, epithelial remains unclear. In this study, prostate (PECs) released miR-203a-3p-rich exosomes facilitated (PSCs) inflammation by upregulating MCP-1 expression. Mechanistically, DUSP5 was...