A5102932996- Gastric Cancer Management and Outcomes
- Anesthesia and Sedative Agents
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Neurotoxicity Research
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Chromatography in Natural Products
- Protease and Inhibitor Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Angiogenesis and VEGF in Cancer
- Epilepsy research and treatment
- Lung Cancer Research Studies
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Traditional Chinese Medicine Analysis
- Metastasis and carcinoma case studies
- Plant-based Medicinal Research
- Pathogenesis and Treatment of Hiccups
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal motility and disorders
- Cancer Mechanisms and Therapy
Huaibei Mining (China)
2020-2025
Zhejiang University
2024-2025
Jiangsu University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Fudan University
2024
Sun Yat-sen University
2024
Zhongshan Hospital
2024
Shanghai East Hospital
2024
Yixing People's Hospital
2024
Peking University
2020-2023
Tumor cells reshape iron and lipid metabolism for their rapid proliferation. However, how tumor coordinate the interplay between cell–specific homeostasis reprogramming to counteract energy shortages remains unclear. Here, we demonstrated that glucose deprivation in hepatocellular carcinoma (HCC) induced AMPK-dependent Transferrin S685 phosphorylation, which exposed nuclear localization signal (NLS) binding importin α7 subsequent translocation. Nucleus-translocated interacts with PPARα...
Objective Camrelizumab, a programmed death-1 inhibitor, is effective and safe for treating patients with advanced lung cancer according to previous phase 3 trials. However, relevant real-world clinical evidence required. This study intended explore the efficacy safety of camrelizumab-based therapies in cancer. Methods Patients who received as first-line or above treatment were consecutively enrolled this study. The median follow-up duration was 5 months. Results A total 298 subjects...
Background: In China, gastric cancer (GC) ranks second in incidence and mortality. Over 80% of patients with GC were diagnosed at an advanced stage poor clinical outcome. Chemotherapy was the mainstream treatment limited benefit. Apatinib, inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2), has been approved for third-line cancer. However, data apatinib real-world setting are limited. this study, we aimed to understand current pattern apatinib, investigate...
ObjectiveThis study aimed to explore the mechanism of Danggui Jixueteng decoction (DJD) in treating Myelosuppression after chemotherapy (MAC) through network pharmacology and metabolomics.MethodsWe obtained chemical structures DJD compounds from TCMSP PubMed. SwissTargetPrediction, STITCH, CTD, GeneCards, OMIM were utilized acquire component targets MAC-related targets. We identified key compounds, core targets, main biological processes, signaling pathways related by constructing analyzing...
Context. Modified Chaihu Shugan powder (MCSP) is a popular traditional Chinese herbal formula for functional dyspepsia, which revised from San and recorded in medical classic works of China. However, its role effect treating dyspepsia have not been well established. Objective. To assess the safety modified dyspepsia. Methods. We searched published unpublished studies up to August 2012. Only RCTs with or without prokinetic drugs versus patients diagnosed were included. Results. Twenty-two...
Abstract Apatinib has been demonstrated to be effective and safe among patients with gastric cancer failing after at least two lines chemotherapy. This study aimed evaluate its effectiveness safety of low‐dose apatinib for the treatment in real‐world practice. We performed a prospective, multicenter observation setting. Patients advanced more than 18 years old were eligible received (500 mg or 250mg per day) therapy. The median progression‐free survival (PFS), overall (OS), objective...
Objectives: In this study, we characterise the imaging-mode performance of positron emission tomography (PET) subsystem RefleXion X1 machine using NEMA NU-2 2018 standard. Methods: The consists two symmetrically opposing 900 arcs PET detectors incorporated into architecture a ring-gantry linear accelerator rotating up to 60 RPM. emissions from tumour are detected by and used guide delivery radiation beam. Imaging on was evaluated based sensitivity detectors, spatial resolution, count-loss...
Abstract Background Right-side heart mass can be found incidentally on routine transthoracic echocardiography (TTE). Accurate diagnosis of cardiac often requires more than one imaging method. We present a mid-age woman with non-Hodgkin lymphoma who was to have multiple right atrial masses mimicking metastases TTE, which were finally diagnosed as thrombi by multimodal imaging. Case presentation A 52-year-old primary mediastinal diffuse large B cell (DLBCL) almost six months prior. The TTE...
Gastric cancer is a global public health burden, nearly one million new cases are diagnosed per year worldwide, of which 44% occur in China. The prognosis gastric varies remarkably by the stage cancer, and most patients China at advanced stages, resulting poor prognoses. Effective strategies to reduce burden include primary prevention through testing treatment <i>Helicobacter pylori</i> (<i>H. pylori</i>) secondary screening early detection. Although many countries have issued management...
Rocuronium is widely utilized in clinical general anaesthesia, and individual differences pharmacology clearance have been observed. Two hundred thirty-six Chinese patients undergoing selective thyroid/breast mass resection were studied. Total intravenous anaesthesia was induced with a single dose of propofol (2 mg·kg-1 ), sufentanil (0.5 μg·kg-1 rocuronium (0.6 ) maintained (3-5 ·h-1 remifentanil (0.2-0.4 ·min-1 ). Intubation conditions train-of-four index to assess the effects duration...
Remimazolam is a new type of ultra-short-effect intravenous anesthetic, that may provide adequate sedation for endoscopy while causing less cardiovascular or respiratory disturbance than propofol. The aim this clinical study was to compare the efficacy and safety two different doses remimazolam with propofol during colonoscopy.
Background and aims: Hepatocellular carcinoma (HCC) recurrence is a major factor limiting long-time survival the cause of most deaths in patients with HCC. However, molecular characterisation potential therapeutic targets recurrent HCC remain mostly unknown. Approach results: We performed whole-exome sequencing (WES) 63 matched primary tumours combined data whole-genome (WGS) results 43 paired samples from our previous study. Sanger was used to identify all low-density lipoprotein...
To investigate the vasodilative action and possible mechanisms of Shenmai injection on porcine coronary artery.Isometric tensions artery ring precontracted with potassium chloride (KCl) were recorded in vitro when doses 0.1, 0.5, 1, 5, 10, 50 mL x L(-1) injective cumulatively added into organ bath ring.Shenmai caused same vasorelaxation rings endothelium intact denuded KCl a concentration-dependent manner. Pretreatment TEA 4-AP prohibited by injection, but pretreatment KB-R7943, BaCl2, Gli...
Abstract BackgroundIn the glioma microenvironment, infiltrating immune cells has been shown to possess beneficial effects for tumor progression. Immune and stromal dominate microenvironment in glioma. The complex interplay between progression with or was still unknown. MethodsIn this study, we used Estimation of malignant tissues using expression data (ESTIMATE) calculations calculate proportion tumour-infiltrating (TIC) number components cases from cancer Genome Atlas (TCGA) Chinese Glioma...
e21056 Background: Camrelizumab, as a humanized antibody against PD-1, has shown high efficiency and survival benefits in clinical studies on lung cancer treatment. This study aims to observe the efficacy safety of Camrelizumab treatment advanced real world. Methods: is prospective, open, multi-center observational that includes patients with who are older than 18 years age, regardless gender, an ECOG score 0-2. Results: As November 18, 2020, total 253 have been enrolled. Males accounted for...
Objective To identify factors associated with weight loss during radiotherapy (RT) in patients esophageal cancer.Methods One hundred and two cancer who received were enrolled as our subjects.Patients' weight,characteristics,dietary intake,tumor treatment data,acute adverse effects collected.Anderson Symptom Inventory was performed.Multiple linear regression analysis applied to independent RT.Results The average RT (1.64 ± 0.69) kg,ranged from 0 5.00 kg.Multiple showed that the lower dietary...
Objective To investigate the effects of real-time three-dimensional echocardiography(RT-3DE) evaluation sacubitril/valsartan and valsartan in treatment chronic heart failure(CHF). Methods A retrospective study was performed on 96 cases patients with CHF who were admitted from January 2018 to 2019.According different treatment, divided into two groups, 53 group, 34 males 19 females, aged(58.14 ± 6.62) years, ranging 46 72 years old, took oral administration basis conventional...