A5038132148- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cancer Immunotherapy and Biomarkers
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- AI in cancer detection
- Cardiac Valve Diseases and Treatments
- Ferroptosis and cancer prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
- Acute Kidney Injury Research
- Advanced X-ray and CT Imaging
- Chronic Kidney Disease and Diabetes
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
Janssen (United States)
2021-2023
Northwestern University
2020-2022
Jackson Laboratory
2021-2022
Rutgers, The State University of New Jersey
2021
Rutgers New Jersey Medical School
2021
Seoul National University Hospital
2011-2020
Naju National Hospital
2017-2020
Ministry of Health and Welfare
2017-2020
Northwestern Medicine
2019-2020
Sungkyunkwan University
2016-2019
Background In patients with ST-segment-elevation myocardial infarction, timely reperfusion therapy door-to-balloon (D2B) time <90 minutes is recommended by the current guidelines. However, whether further shortening of symptom onset-to-door (O2D) or D2B would enhance survival infarction remains unclear. Therefore, study aimed to evaluate prognostic impact O2D in who underwent primary percutaneous coronary intervention. Methods and Results We analyzed 5243 were treated at 20 tertiary...
Abstract Aims Identification of invasive and radionuclide imaging markers coronary plaque vulnerability by a single, widely available non-invasive technique may provide the opportunity to identify vulnerable plaques patients in broad populations. Our aim was assess whether radiomic analysis outperforms conventional assessment computed tomography angiography (CTA) images vulnerability. Methods results We prospectively included who underwent CTA, sodium-fluoride positron emission (NaF18-PET),...
Recently, resting pressure-derived indexes such as full-cycle ratio (RFR) and diastolic pressure (dPR) have been introduced to assess the functional significance of epicardial coronary stenosis. The present study sought investigate agreement RFR or dPR with other (instantaneous wave-free [iFR] fractional flow reserve), sensitivity for anatomic hemodynamic stenosis severity, prognostic implications compared iFR Methods: were calculated from tracings by an independent core laboratory in 1024...
To assess the distribution of pressure and shear-related forces acting on atherosclerotic plaques their association with lesion characteristics using coronary CT angiography (cCTA)-based computational fluid dynamics (CFD) model epicardial arteries.Patient-specific models arteries were reconstructed from cCTA in 80 patients (12 women, 63.8±9.0 years). The wall shear stress (WSS) left anterior descending assessed CFD. High-risk defined as presence at least one following adverse plaque...
There are limited data on the clinical implications of total physiologic atherosclerotic burden assessed by invasive studies in patients with coronary artery disease. We investigated prognostic sum fractional flow reserve (FFR) three vessels (3V-FFR). A 1136 underwent FFR measurement (3V FFR-FRIENDS study, NCT01621438). The were classified into high and low 3V-FFR groups according to median value (2.72). primary endpoint was major adverse cardiac events (MACE, a composite death, myocardial...
Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) panel, including MBF, coronary reserve (CFR), and relative (RFR) conjunction with defect (PD) assessments to better detect functionally significant artery stenosis.A total 130 patients (307 vessels) disease underwent both (13)NH3-PET...
Background— 18 F-sodium fluoride ( F-NaF) positron-emission tomography has been introduced as a potential noninvasive imaging tool to identify plaques with high-risk characteristics in patients coronary artery disease. We sought evaluate the clinical relevance of F-NaF uptake using optical coherence (OCT), intravascular ultrasound (IVUS), and computed angiography Methods Results— The target population consisted 51 prospectively enrolled (93 stenoses) who underwent before invasive...
In contrast to CD34, vascular endothelial-cadherin (VE-cadherin) is exclusively expressed on the late endothelial progenitor cells (EPC) whereas not early or myeloid EPC. Thus, VE-cadherin could be an ideal target surface molecule capture circulating present study, we evaluated whether anti-VE-cadherin antibody-coated stents (VE-cad stents) might accelerate recovery and reduce neointimal formation through ability of capturing EPC.The stainless steel were coated with rabbit polyclonal...
The authors investigated 2-year clinical outcomes according to fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) values in deferred lesions.Invasive physiological indices such as FFR or iFR are used practice select ischemia-causing stenosis guide the treatment strategy for patients with coronary artery disease.From 3V FFR-FRIENDS (3-Vessel Fractional Flow Reserve Assessment of Total Stenosis Burden Its Clinical Impact Patients With Coronary Artery Disease) study, 821...
The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer vascular leakage and angiogenesis both which are fundamental pathophysiology retinopathy. aim this study was investigate the effects DPP4-inhibitors on permeability DPP4-inhibitor (diprotin A or sitagliptin) increased phosphorylation Src endothelial-cadherin...