A5052491557- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- COVID-19 and healthcare impacts
- Reconstructive Surgery and Microvascular Techniques
- Global Cancer Incidence and Screening
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- MRI in cancer diagnosis
- BRCA gene mutations in cancer
- Spectroscopy and Chemometric Analyses
- Cutaneous Melanoma Detection and Management
- Reconstructive Facial Surgery Techniques
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Economic and Financial Impacts of Cancer
- Digital Imaging in Medicine
- Optical Imaging and Spectroscopy Techniques
- Metabolism, Diabetes, and Cancer
- Cancer and Skin Lesions
Nottingham University Hospitals NHS Trust
2016-2024
Nottingham City Hospital
2018-2024
Breast Cancer Care
2024
University Hospitals of Leicester NHS Trust
2023
Glenfield Hospital
2016-2023
University of Birmingham
2020-2022
Queen's University Belfast
2022
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on biology remains understudied humans. This study investigates how the untreated primary differs according to patients' body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent overweight or obese patients compared lean report evidence supporting ageing accelerating effect obesity at genetic...
Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is key enzyme ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 breast ductal carcinoma situ (DCIS).P4HA2 expression was assessed immunohistochemically malignant cells and surrounding stroma large DCIS cohort comprising 481 pure 196 mixed invasive carcinomas. Outcome analysis evaluated using local recurrence free interval (LRFI).High detected half whereas its...
Abstract Intraoperative assessment of surgical margins remains one the main challenges in cancer surgery. Raman spectroscopy can detect cells with high accuracy, but it is time‐consuming. In this paper, we investigated a selective‐sampling approach, based on wavenumber (HW) imaging (spectral range 2,500–3,500 cm −1 ) and fingerprint 600–1,800 ), to reduce overall tissue analysis time while maintaining diagnostic accuracy. HW mapping was used as first step identify adipose regions C–H...
Abstract Background Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression ductal carcinoma situ (DCIS) terms outcome impact on ET decision. Methods total, 643 pure DCIS, diagnosed at Nottingham University Hospitals, were assessed for ER. Clinicopathological data correlated against status, together with assessment recurrence rate. Results positivity was...
The standard treatment for breast cancer is surgical removal mainly through breast-conserving surgery (BCS). We developed a new technique based on auto-fluorescence (AF) spectral imaging and Raman spectroscopy fast intraoperative assessment of excision margins in BCS. A wide-field AF unit total internal reflection (TIR) was combined with microscope equipped 785 nm laser. wavelength the excitation optimized to 365 order maximize discrimination adipose tissue. This approach allows non-adipose...
Management of breast ductal carcinoma in situ (DCIS) has various approaches with distinct institutional specific practice. Here, we review DCIS management a single institution emphasize on re-operation rates and outcome.Breast cases diagnosed at the Nottingham Breast Institute between 1987 2017 were identified (n = 1249). Clinicopathological data collected. Cases histologically reviewed, different factors associated primary operation selection, re-excision, presence residual tumor...
Visceral artery aneurysms are very rare. Patients usually present as emergency secondary to the sudden rupture of aneurysm or an incidental finding on ultrasound, MRI abdominal computed tomography. Among these, splenic most common ones accounting for 60% all splanchnic and gastric gastroepiploic account only about 4%.We a 61-year-old Caucasian male previously fit well, presenting with onset epigastric pain due retroperitoneal haemorrhage ruptured left aneurysm. Apart from tender epigastrium,...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Background and objectives Sentinel lymph node (SLN) biopsy is a standard procedure for patients with breast cancer normal axilla on imaging. Positive SLNs histological examination can lead to subsequent surgery axillary clearance (ALNC). Here we report non-destructive technique based autofluorescence (AF) imaging Raman spectroscopy intra-operative assessment of excised in surgery. Methods A microscope integrating AF modules was built allow scanning samples. During AF-Raman...
We report a 73 year old gentleman with localised pericardial tamponade following coronary artery bypass grafting. The patient had low cardiac output without any evidence of myocardial ischaemia. A transthoracic echocardiogram was not diagnostic. Computed tomography (CT scan) the chest revealed large collection in pericardium leading to left ventricular collapse. When classical clinical signs are present and echocardiography is inconclusive, then CT scan helpful confirm or exclude suspicion tamponade.