A5100694100- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Food Quality and Safety Studies
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Healthcare and Venom Research
- Helicobacter pylori-related gastroenterology studies
- Natural Compounds in Disease Treatment
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Chemical Thermodynamics and Molecular Structure
- Reproductive Biology and Fertility
- 14-3-3 protein interactions
- Morinda citrifolia extract uses
- Cell death mechanisms and regulation
- Health and Wellbeing Research
- Acupuncture Treatment Research Studies
Beijing University of Chinese Medicine
2013-2025
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2024
Beijing Radiation Center
2018
Sichuan University
2018
West China Hospital of Sichuan University
2018
Wuhan Research Institute of Materials Protection
2016
Huazhong Agricultural University
2015
Experimental Center of Forestry in North China
2013
Chinese Academy of Fishery Sciences
2013
Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford certain anti-febrile action. However, seldom does research concern pharmacological mechanisms SHLI. In current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to...
Semen Cuscutae is a well‐known Chinese medicine which has been used to nourish kidney in China for thousands of years. The crude product semen (CP) and its salt‐processed (SPP) are separately clinic their different effects. study was designed investigate the influence processing from on chemical components biological principal component analysis quantitative were differences components. effects nourishing detected compare between CP SPP. PCA results showed that obvious separation achieved...
Jiaqi Ganxian Granule (JGG) is a famous traditional Chinese medicine, which has been long used in clinical practice for treating liver fibrosis. However, the mechanism underlying its anti-hepatic fibrosis still not clear. In this study, an Ultra-Performance Liquid Chromatography-Time-Of-Flight Mass Spectrometry (UPLC-TOF-MS)-based metabolomics strategy was to profile metabolic characteristic of serum obtained from carbon tetrachloride (CCl₄)-induced hepatic model Sprague-Dawley (SD) rats...
Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic to treat acute respiratory tract infection, pneumonia, influenza, and so forth. Despite the widespread clinical application, prototype components metabolites of SHLI have not fully elucidated, especially human body. To discover screen constituents or medicine biofluids tends be more difficult due complexity chemical compositions, metabolic reactions matrix effects. In this work,...
Sitaxsentan (3, TBC11251) (Wu et al. J. Med. Chem. 1997, 40, 1690) is an orally active ET(A) selective endothelin antagonist that attenuates pulmonary vascular hypertension and cardiac hypertrophy in rats (Tilton Pulm. Pharmacol. Ther. 2000, 13, 87). It has demonstrated efficacy a phase II clinical trial for congestive heart failure (Givertz Circulation 101, 2922). During the discovery of 3, we observed several structure-oral bioavailability relationships. To investigate whether there any...
Objective . Berberine has been used to treat nonalcoholic steatohepatitis (NASH), which addressed in many studies. In this study, we investigated the molecular pharmacology mechanisms of berberine using metabolomic techniques. Methods Sprague-Dawley rats were randomly divided into three groups (10 each group): (i) normal control group; (ii) high-fat diet- (HFD-) induced NASH model and (iii) HFD berberine-treated group (i.d. 200 mg/kg). The handling procedure lasted eight weeks. Then,...
With the objective of finding valuable herbicidal candidates, a series new 5-heterocycloxy-3-methyl-1-substituted-1H-pyrazoles were synthesized and their activities evaluated. The bioassay results showed that some compounds exhibited excellent at concentration 100 mg/L, compound 5-chloro-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)oxy)pyrimidine bleaching activity to green weeds. In greenhouse conditions, this also post-emergence effect against Digitaria sanguinalis L. dosage 750 g...
Phytolacca acinosa Roxb (PAR), a traditional Chinese medicine, has been widely used as diuretic drug for long period of time the treatment edema, swelling, and sores. However, it reported that PAR might induce hepatotoxicity, while mechanisms its toxic effect are still unclear. In this study, network toxicology metabolomic technique were applied to explore PAR-induced hepatotoxicity on zebrafish larvae. We evaluated ultrastructure function liver, predictive targets, pathways in toxicology,...
To identify the constituents in Shuanghuanglian injection (SHLI) that correlate with anaphylactoid reaction.Chemical fingerprints of 10 batches SHLI samples were determined by High Performance Liquid Chromatography (HPLC), and further investigated similarity analysis. Combined optical microscopy, both experiments confirmatory assay displayed Rat basophil leukemia cells (RBL-2H3) to obtain histamine release inducing SHLI. The content was tested Enzyme-Linked Immuno Sorbent Assay method....
Objectives . To investigate whether Panax ginseng ( P. ) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo. Methods and Results 24 male Sprague‐Dawley rats were randomized for 7‐day treatment with (low, middle, high), or vehicle. was administered orally to each group on 8th day. Plasma samples collected, Xevo TQ‐S used detect concentration aconitine, mesaconitine, hypaconitine plasma. We describe a fast reproducible method Compared control...
To investigating the molecular mechanism of herbal pairs in three types Chinese medicinals: Qi-tonifying, blood activation, blood-stasis breaking treatment coronary heart disease (CHD). The components six herbs were searched medicine dictionary and their target proteins found PubChem. CHD genes obtained from PubMed gene database. Ingenuity Pathways Analysis was used to build pharmacological network network. canonical pathways between each pair compared decipher on treating CHD. analysis...
Chinese herbal medicine are the main means to prevent and treat diseases in traditional medicine, thus quality of medicinal herbs decides clinical efficacy. Though producing areas genuine medical had been recorded Qing Han Dynasties, not finally established thrived until Ming Dynasties. Their development more than 1 000 years was affected by many factors. Thepractice examination theoretical direction TCM were basis for generation herbs, while differences ecological environment germplasm...
To explore the pharmacological mechanism of a Chinese patent drug (Kunling Pill (KLP)) on improving diminished ovarian reserve based proteomic analysis.A total 18 patients divided into three groups (the normal ovary (NOR), (DOR), and KLP groups) undergoing assisted reproductive technology by standard stimulation protocols were recruited to collect follicular fluid. Data-independent acquisition mass spectrometry was used identify differentially expressed proteins nano-LC-MS/MS. Bioinformatic...