A5034147882- Veterinary Oncology Research
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- IL-33, ST2, and ILC Pathways
- Microbial infections and disease research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Animal Disease Management and Epidemiology
- Genital Health and Disease
- Virus-based gene therapy research
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Vector-Borne Animal Diseases
- T-cell and B-cell Immunology
- Animal Virus Infections Studies
- Veterinary Medicine and Surgery
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
- Infant Nutrition and Health
- Cancer Immunotherapy and Biomarkers
Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta
2022-2024
University of Perugia
2018-2024
Gut represents a major immunological defense barrier with mucosal immune system and intestinal epithelial cells (IECs). In all diseases, in particular inflammatory bowel disease (IBD), both the absorption local are compromised alternative effective therapies sought after. Extracellular Vesicles (EVs) have capability to regulate within microenvironment, by dampening inflammation restoring integrity. Recently, immune-modulatory role of EVs has also been confirmed for milk (mEVs), notable their...
Extracellular vesicles (EVs) are nanometric-membrane-bound sub-cellular structures, which can be recovered from milk. Milk EVs have drawn increasing interest due to their potential biomedical applications, therefore it is important investigate impact on key immune cells, such as macrophages.In this work, the immunomodulatory effects of goat milk untreated (moMФ) and classically activated (moM1) porcine monocyte-derived macrophages were investigated using flow cytometry, ELISA, gene...
Extracellular vesicles (EVs) are nanometric spherical structures, enclosed in a lipid bilayer membrane and secreted by multiple cell types under specific physiologic pathologic conditions. Their complex cargo modulates immune cells within an inflammatory microenvironment. Milk is one of the most promising sources EVs terms massive recovery, milk extracellular (mEVs) have immunomodulatory anti-inflammatory effects. The aim this study was to characterize goat mEVs' immunomodulating activities...
Human melanoma is one of the deadliest forms cancer, with poor prognosis and high resistance to chemotherapy radiotherapy. The discovery immunosuppressive mechanisms in human microenvironment led use new prognostic markers development immunotherapies targeting immune checkpoint molecules. Immunoescape canine have not yet been investigated, no such immunotherapy has tested. aim this study was provide preliminary data on expression transcription factor forkhead box protein P3 (FoxP3)...
Papillomaviruses (PVs) are small, non-enveloped viruses, ubiquitous across the animal kingdom. PVs induce diverse forms of infection, such as cutaneous papillomas, genital papillomatosis, and carcinomas. During a survey on fertility status mare, novel Equus caballus PV (EcPV) has been identified using Next Generation Sequencing, it was further confirmed with genome-walking PCR Sanger sequencing. The complete circular genome 7607 bp long shares 67% average percentage identity EcPV9, EcPV2,...
Paratuberculosis is a notable infectious disease of ruminants. Goats appear to be particularly susceptible. The survey aimed investigate the spread paratuberculosis in Italian goat farming and evaluate whether presence could influenced by welfare biosecurity deficiencies. A serological for 33 dairy farms northern Italy was conducted. Contextually, animal were assessed, using standardized protocol 36 indicators 15 which assigns each farm score from 0 (any application) 100% (full application)....
Cancer is a leading cause of death in cats, and the rate such disease has been increasing recently. Nonetheless, feline oncology represents an important area study not only for health wellbeing cats but also human since various types cancer share similarities to those found humans. Therefore, epidemiological studies on may suggest environmental genetic factors contributing which can eventually be translated improve care.
Papillomas are benign epithelial lesions protruding on the surfaces as finger-like or warty projections. These often caused by papillomavirus (PV) infection. Congenital papillomas have been reported in foals. However, to date, no evidence of PV infection has provided. In present paper, we describe main clinical–pathological features a congenital papilloma observed foal. addition, biomolecular tests demonstrated BPV1 case under study. Such data stimulate further investigations, even archived...
Papillomavirus (PV) infections may be related to anogenital lesions and cancer development in humans several other animal species. To date, 11 different PVs have been reported horses. Among them, a newly described PV named Equus caballus Type9 (EcPV9) was thus far only the semen of stallion with penile Australia. This study reports for first time presence EcPV9 asymptomatic Italian From July 2020 January 2022, genital brush samples were collected from 209 horses no apparent signs neoplastic...
Extracellular Vesicles (EVs) are nano-sized double-lipid-membrane-bound structures, acting mainly as signalling mediators between distant cells and, in particular, modulating the immune response and inflammation of targeted cells. Milk colostrum contain high amounts EVs that could be exploited alternative natural systems antimicrobial fighting. The aim this study is to evaluate cow colostrum-derived (colosEVs) for their antimicrobial, anti-inflammatory immunomodulating effects vitro assess...
Toll-like receptor 2 (TLR2) ligands are attracting attention as prophylactic and immunopotentiator agents against pathogens, including viruses. We previously reported that a synthetic diacylated lipopeptide (Mag-Pam2Cys_P48) polarized porcine macrophages towards proinflammatory antimicrobial phenotype. Here, we investigated its role in modulating monocyte-derived macrophage (moMΦ) responses African swine fever virus (ASFV), the etiological agent of one greatest threats to global pig...
Vulvo-vaginal epithelial tumors are uncommon in mares, and data on the epithelial-to-mesenchymal transition (EMT) tumor-immune microenvironment (TIME) still lacking. This is a study investigating equus caballus papillomavirus type 2 (EcPV2) infection state as well EMT process tumor vulvo-vaginal preneoplastic/ benign (8/22) or malignant (14/22) lesions mares. To do this, histopathological, immunohistochemical, transcriptomic, situ hybridization, correlation analyses were carried out....
Abstract Background Vulvar squamous cell carcinoma (VSCC) has been recently associated with Equus caballus papillomavirus type 2 (EcPV2) infection. Still, few reports concerning this disease are present in the literature. Objective To describe a case of naturally occurring EcPV2‐induced VSCC, by investigating tumour ability undergoing epithelial‐to‐mesenchymal transition (EMT). Study design Case report. Methods A 13‐year‐old Haflinger mare was referred for rapidly growing vulvar mass. After...