A5014140013- Crystallization and Solubility Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Chemical Reaction Mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) multidrug-resistant (MDR) TB. In addition, Mycobacterium bovis-induced zoonotic TB (zTB) presents treatment difficulties due to its resistance pyrazinamide the prolonged duration required. This study aims evaluate antitubercular potential β-aminopropioamidoxime derivatives against DS MDR tuberculosis M. bovis strains, utilizing SwissADME prognostic tool...
We have previously obtained new spiropyrazolinium compounds by arylsulfochlorination of β-aminopropioamidoximes. But it was found that under certain conditions, the main or by-product β-(thiomorpholine-1-yl)propioamidoxime tosylation 2-amino-8-thia-1,5-diazaspiro[4.5]dec-1-en-5-ium chloride monohydrate. In case other β-aminopropioamidoximes, only 2-amino-1,5-diazaspiro[4.5]dec-1-en-5-ium arylsulfonates were isolated. The aim work is to perform a theoretical comparison reactions tosylation,...
Amidoxime derivatives have practically valuable biological properties. We previously obtained new spiropyrazolinium compounds by arylsulfo-chlorination of β-aminopropioamidoximes, but in case β-(benzimidazol-1-yl)pro-pioamidoxime we O-substitution product – 3-(1H-benzo[d]imidazol-1-yl)-N'-(tosyloxy)pro-panimidamide. The aim the work is predicting structural parameters (bond lengths, bond angles), vibrational frequencies and NMR spectra...