A5053912964- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Heterocycles
- Natural Antidiabetic Agents Studies
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Synthesis and Catalytic Reactions
- Polymer Synthesis and Characterization
- Chemical Reaction Mechanisms
- Chemical synthesis and pharmacological studies
- Sustainability in Higher Education
- Diet, Metabolism, and Disease
Institute of Chemical Engineering
2019
This article examines the pedagogical aspects of developing professional compe-tencies chemistry teachers in context Sustainable Development Goals (SDGs). In face global challenges, teacher training system requires inte-gration principles Education for (ESD), aimed at fostering critical thinking, systematic analysis, and strategic planning. The ana-lyzes key competencies necessary effective implementation SDGs educational process, including anticipatory fore-casting, normative competencies,...
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) multidrug-resistant (MDR) TB. In addition, Mycobacterium bovis-induced zoonotic TB (zTB) presents treatment difficulties due to its resistance pyrazinamide the prolonged duration required. This study aims evaluate antitubercular potential β-aminopropioamidoxime derivatives against DS MDR tuberculosis M. bovis strains, utilizing SwissADME prognostic tool...
The analysis of stability biologically active compounds requires an accurate determination their structure. We have found that 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles are generally unstable in the presence acids and bases rearranged into salts spiropyrazolinium compounds. Hence, there is a significant probability it products should be attributed to biological activity not primarily screened 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles. A series 2-amino-8-oxa-1,5-diazaspiro[4.5]dec-1-en-5-ium...
Our research area is related to the spiropyrazolinium-containingcompounds, which are insufficiently studied compared with pyrazoline-containing compounds. Nitrogen-containing azoniaspiromolecules have also been well studied. In drug design and other areas, they a priori important structures, since rigid spirocyclic scaffolds reduced conformational entropy able organize closely spaced area. Azoniaspirostructures currently of wide practical interest as ionic liquids, current sources...
We have previously obtained new spiropyrazolinium compounds by arylsulfochlorination of β-aminopropioamidoximes. But it was found that under certain conditions, the main or by-product β-(thiomorpholine-1-yl)propioamidoxime tosylation 2-amino-8-thia-1,5-diazaspiro[4.5]dec-1-en-5-ium chloride monohydrate. In case other β-aminopropioamidoximes, only 2-amino-1,5-diazaspiro[4.5]dec-1-en-5-ium arylsulfonates were isolated. The aim work is to perform a theoretical comparison reactions tosylation,...