A5044065877- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Diagnosis and treatment of tuberculosis
- vaccines and immunoinformatics approaches
- Infectious Diseases and Tuberculosis
- Synthesis and Biological Evaluation
- Soviet and Russian History
- Methane Hydrates and Related Phenomena
- Phenothiazines and Benzothiazines Synthesis and Activities
- RNA and protein synthesis mechanisms
- Chemical synthesis and pharmacological studies
- Astronomy and Astrophysical Research
- Synthesis and Reactivity of Heterocycles
- Polymer Synthesis and Characterization
- Bacteriophages and microbial interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Biochemical and Molecular Research
- Genomics and Phylogenetic Studies
- Geophysics and Gravity Measurements
- Russia and Soviet political economy
Kazakh Institute of Oncology and Radiology
2020-2023
National Science Center
2019
National Center for Tuberculosis and Lung Disease
2014
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) multidrug-resistant (MDR) TB. In addition, Mycobacterium bovis-induced zoonotic TB (zTB) presents treatment difficulties due to its resistance pyrazinamide the prolonged duration required. This study aims evaluate antitubercular potential β-aminopropioamidoxime derivatives against DS MDR tuberculosis M. bovis strains, utilizing SwissADME prognostic tool...
Pyrazinamide (PZA), an important first-line drug for anti-tuberculosis treatment, demonstrates potent activity against semi-dormant bacilli in acidic environments. However, the diagnosis of PZA resistance is often impeded by technical difficulties.To characterise mutations pncA and rpsA genes among PZA-resistant PZA-susceptible clinical Mycobacterium tuberculosis isolates circulating Kazakhstan. The potential use genotyping to identify was also investigated.PZA susceptibility testing gene...
Kazakhstan is one of the 14 countries with a high rate morbidity due to multidrug-resistant tuberculosis (MDR TB) in WHO European region. The aim our study was characterize mutations associated drug resistance rifampicin and isoniazid Mycobacterium isolates from Kazakhstan. M. strains were isolated TB patients different regions A susceptibility test performed on Lowenstein-Jensen medium using absolute concentration method. Sequencing analysis rpoB resistance-determining region katG gene,...
Abstract The human leukocyte antigen ( HLA ) system has a major role in the regulation of immune response as it is involved defense against pathogens. Some studies have reported that class II genes play strong severe cases pulmonary tuberculosis (PTB) several populations. Thus aim study was to compare HLA‐class alleles patients with drug resistant those healthy controls from same ethnic group Kazakhstan. present evaluate correlation ‐class by and 76 TB 157 volunteers were investigated using...
The analysis of stability biologically active compounds requires an accurate determination their structure. We have found that 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles are generally unstable in the presence acids and bases rearranged into salts spiropyrazolinium compounds. Hence, there is a significant probability it products should be attributed to biological activity not primarily screened 5-aryl-3-(2-aminoethyl)-1,2,4-oxadiazoles. A series 2-amino-8-oxa-1,5-diazaspiro[4.5]dec-1-en-5-ium...
Kazakhstan has a high burden of multidrug-resistant tuberculosis in the Central Asian region. This study aimed to perform genomic characterization Mycobacterium strains obtained from Kazakhstani patients with pre-extensively drug-resistant diagnosed Kazakhstan.Whole-genome sequencing was performed on 10 M. different regions Kazakhstan. All had high-confidence resistance mutations according grading system previously established by World Health Organization. The genome analysis using...
The Beijing genotype is the most distributed M. tuberculosis family in Kazakhstan. In this study, we identified dominant clusters Kazakhstan and assessed their drug susceptibility profiles association with widely spread mutation Ser531Leu of rpoB gene Ser315Thr katG associated resistance to rifampicin isoniazid, respectively. isolates (n = 540) from new TB cases were included study. MIRU-VNTR genotyping was performed for 540 clinical determine families using 24 loci. RD analysis additionally...
Tuberculosis (TB) is an infectious disease that remains essential public health problem in many countries. Despite decreasing numbers of new cases worldwide, the incidence antibiotic-resistant forms (multidrug resistant and extensively drug-resistant) TB increasing. Next-generation sequencing technologies provide a high-throughput approach to identify known novel potential genetic variants are associated with drug resistance Mycobacterium tuberculosis (Mtb). There limited reports data...
Drug-resistant tuberculosis (TB) is a major public health problem. Clinical Mycobacterium (MTB) isolate with Extensively drug-resistant (MTB-XDR) profile was subjected to whole-genome sequencing using next-generation platform (NGS) Roche 454 GS FLX+ followed by bioinformatics sequence analysis. Quality of read checked FastQC, paired-end reads were trimmed Trimmomatic. De novo genome assembly conducted Velvet v.1.2.10. The assembled XDR-TB-1599 strain functionally annotated the PATRIC...
Here, we report the draft genome sequences of two clinical isolates Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated from sputum Kazakh patients.
Туберкулез (ТБ) все еще остается одной из актуальных проблем медицины в Казахстане. Казахстан входит тридцатку стран с высокими показателями ТБ множественной лекарственной устойчивостью (МЛУ-ТБ), ассоциированного к самым эффективным антибиотикам первого ряда – рифампицину и изониазиду. Согласно исследованиям, МЛУ-ТБ взаимосвязан генотипом Beijing. 95% рифампицин- 50-95% изониазид-устойчивых M. tuberculosis имеют мутации rpoB katG генах, наиболее распространенными являются Ser531Leu 531...
Background: Tuberculosis is a major public health problem which infects one third of the world’s population, resulting in more than two million deaths every year. The emergence whole genome sequencing (WGS) technologies as primary research tool has allowed for detection genetic diversity Mycobacterium tuberculosis (MTB) with unprecedented resolution. WGS been used to address broad range topics, including dynamics evolution, transmission, and treatment. To our knowledge, studies involving...
Introduction. Methods of genotyping M. tuberculosis play an important role in tuberсulosis (TB) infection control. These techniques are used to detect or exclude laboratory errors, control recurrent cases, and determine ways TB transmission. Today, there more than 10 methods genotyping; MIRU-VNTR is one the most widely world. In this study we aimed estimate biological diversity clinical isolates from different regions Kazakhstan based on analysis.Materials methods. was genotype 134 isolated...
Search for new tuberculostatics is an important task medicinal chemistry. A series of O-aroyl-β-(4-phenylpiperazin-1-yl)propioamidoximes were synthesized and tested antituberculous activity in vitro. The synthesis the target substances consists 3 - 4 stages. At first stage, β-(4-phenylpiperazin-1-yl)propionitrile was obtained with a yield 79%; second stage yields β-(4-phenylpiperazin-1-yl)propioamidoxime at amount 75%. subsequent aroylation this amidoxime by substituted benzoic acid...
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