A5099853071- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Chemical Synthesis and Reactions
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) multidrug-resistant (MDR) TB. In addition, Mycobacterium bovis-induced zoonotic TB (zTB) presents treatment difficulties due to its resistance pyrazinamide the prolonged duration required. This study aims evaluate antitubercular potential β-aminopropioamidoxime derivatives against DS MDR tuberculosis M. bovis strains, utilizing SwissADME prognostic tool...
We have studied the regioselectivity of alkylsulfochlorination β-(4-phenylpiperazin-1-yl)- and β-(benzimidazol-1-yl)-propioamidoximes using AlkSO2Cl under two conditions: (i) in chloroform presence tributylamine (Bu3N) as a base at room temperature (r.t.); (ii) water acetone (4:1) without Bu3N r.t. The reaction conditions leads to return original amidoximes, formation 2-amino-8-phenyl-1,5,8-triazaspiro[4.5]dec-1-ene-5-ammonium chloride β-(benzimidazole-1-yl)propioamidoxime hydrochloride....