A5065703867- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of Organic Compounds
- Agriculture and Biological Studies
- Synthesis of Indole Derivatives
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Phosphorus compounds and reactions
- Synthesis of heterocyclic compounds
- Organophosphorus compounds synthesis
- Carbohydrate Chemistry and Synthesis
- Computational Drug Discovery Methods
- Agricultural Productivity and Crop Improvement
- Fungal Biology and Applications
- Macrophage Migration Inhibitory Factor
- Medicinal plant effects and applications
- Plant chemical constituents analysis
- Chemical synthesis and pharmacological studies
- Scientific Research and Studies
- Fungal Plant Pathogen Control
- Synthesis and Biological Evaluation
Al-Farabi Kazakh National University
2024
Master's College
2023
Candid
2023
Institute of Chemical Engineering
2014-2020
RWTH Aachen University
2010
Ministry of Education and Science of the Republic of Kazakhstan
2002-2006
A new organocatalytic quadruple domino Friedel-Crafts-type/Michael/Michael/aldol condensation reaction has been developed. In this one-pot multi-component process acrolein, various indoles and nitroalkenes are used as starting materials. The diphenylprolinol TMS-ether catalysis provides a straightforward efficient entry to 3-(cyclohexenylmethyl)-indoles bearing three stereogenic centers in moderate excellent yields (23-82%) stereoselectivities (dr = 91 : 9 >95 5, ee 94 >99%).
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) multidrug-resistant (MDR) TB. In addition, Mycobacterium bovis-induced zoonotic TB (zTB) presents treatment difficulties due to its resistance pyrazinamide the prolonged duration required. This study aims evaluate antitubercular potential β-aminopropioamidoxime derivatives against DS MDR tuberculosis M. bovis strains, utilizing SwissADME prognostic tool...
A high pharmacological ability of aromatic benzaldehydes makes them important intermediates for the synthesis medicinal preparations, such as anticancer, bactericidal, antifungal, and herbicidal drugs. The purpose this work is biologically active compounds, based on 4-hydroxybenzaldehyde 4-hydroxy-3-methoxybenzaldehyde establishment structure synthesized compounds. Results discussion. New carbonodithioates, O-aromatic systems have been by interaction with carbon disulfide in presence sodium...
In this study, nineteen thioanhydrides were synthesized from the S-acylation reaction of sodium dithiocarbamates with various acyl chlorides in chloroform at room temperature. The evaluated for their growth-stimulating and phytotoxic activities. Benzoic (1a), 4-methoxy- (1b), 4-chloro- (1c), 2-bromo- (1e), 4-fluoro- (1f.) 4-nitrobenzoic 1H-1,2,4-triazole-1-carbothioic (1 g) showed moderate to excellent activity, along (1c) exhibited 2,4-dichlorobenzoic thioanhydride (1d)...
Mono- and diacetylenic alcohols glycols of the tetrahydrothiopyran row were synthesized by Favorskii reaction. Steric structures compounds established NMR (1H 13C) Mass spectra. The antibacterial, antifungal antileishmanial activities screened. Compounds 1, 6 7 found to be more active than others against Staphylococcus aureus (IC50 =10.05, 1.38, 10.28 µg/mL) Methicillin-resistant =18.2, 1.14, 12.85 µg/mL), respectively. Only compound showed good activity Mycobacterium intracellulare with...
Particular attention in the cultivation of industrial and agricultural crops is paid to fight against pathogenic fungi, which not only lead significant yield losses, but they are also dangerous humans. The aim this work synthesis biologically active compounds series aromatic dithiocarbamic acids based on N-(4-methoxyphenyl)acetamide N-phenylacetamide study their antifungal antibacterial activities. Results discussion. Biologically sodium dithiocarbamates were synthesized by reaction amines...
Nitrogen-containing heterocycles are structural elements of many synthetic and endogenous biologically active substances. In this regard, they have particular interest as objects study the relationship between structure biological activity. The aim work is development new plant growth stimulants, based on nitrogen-containing heterocyclic dithiocarbamic acids their inclusion complexes with arabinogalactan, root-forming Results discussion. Synthesis sodium dithiocarbamate...
Morpholine is a promising and versatile six-membered heterocycle, popular pharmacophore with wide spectrum of biological pharmacological activity. The purpose this work the synthesis biologically active compounds, based on 3-morpholinepropylamine, determination structure activity synthesized compounds. Results discussion. Acetic, propionic, benzoic, 4-chlorobenzoic 2,4-dichlorobenzoic 3-morpholinopropylcarbamothioic thioanhydrides have been as result acylation sodium...
Abstract The one‐pot multi‐component process involves the cascade reaction of nitroalkenes (II), indole derivatives (I) and two equivalents acrolein (III) catalyzed by a prolinol Tms‐ether derivative.
Interest in numerous naphthylamine derivatives is due to a wide range of their biological activity (growth-stimulating, antimicrobial, anticancer, antiviral, antihypertensive, antidiabetic, etc.). The aim the workis synthesis biologically active N,S,O-containing substances series acetylenic, alkoxy- and aroxyalkyl esters naphthylamine. Study acylation, propargylation alkylation reactions naphthalene-1-yl-bis(sodium carbamodiothioate). Methodology. New naphthylbisdithiocarbamic acid were...
One of the main tasks organic chemistry is development purposeful synthesis ways biologically active substances. The dithiocarbamic compounds opens up wide possibilities for solving this problem. There a strong interest in acids due to range oftheir biological activity (anticancer, antibacterial, antifungal, anti-neurodegenerative, anti-tuberculosis, growthstimulating, root forming, etc.). purpose studyis substances inthe series element(N-,O-,S-,F-,Cl-)organic based on N-benzylmethylamine...