A5075258869- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Antifungal resistance and susceptibility
- RNA Interference and Gene Delivery
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- CAR-T cell therapy research
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Histiocytic Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Eosinophilic Disorders and Syndromes
- Advanced biosensing and bioanalysis techniques
- CNS Lymphoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Monoclonal and Polyclonal Antibodies Research
University of Modena and Reggio Emilia
2015-2024
Azienda Ospedaliero-Universitaria di Modena
2010-2021
European Commission
2009
Italian Association for Cancer Research
2009
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2008
University of California, San Francisco
2008
University of Brescia
2006
Medizinische Hochschule Hannover
2006
University of Liverpool
2000
University of Parma
2000
Independent epidemiologic studieshave shown a strong association be-tween Kaposi’s sarcoma (KS) and infec-tion with human herpesvirus 8 (HHV-8or KSHV). HHV-8 genomic sequenceshave been found in all forms (1–5)andall histologic stages (6) of KS, viralDNA being localized to tumor endothe-lial cells spindle (7,8). Detec-tion DNA sequences theperipheral blood patients who are se-ropositive for immunodeficiencyvirus 1 (HIV) is predictor ofprogression KS (9,10). The vast ma-jority have antibod-ies...
Human herpesvirus 8 (HHV-8) infection has been linked to the development of Kaposi's sarcoma and rare lymphoproliferative disorders.
Abstract Saliva and peripheral blood mononuclear cells from three patients, two with lymphoproliferative disorders one suffering multiple sclerosis, were examined for the presence of human herpesvirus‐6 (HHV‐6) genome by using polymerase chain reaction Southern blot analysis. The search anti‐HHV‐6 antibodies, carried out in sera same cases an immunofluorescence assay, was negative at lowest dilution used (1:40). These patients had a high number HHV‐6 specific sequences uncultured cells,...
ABSTRACT We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells patients with latent HHV-6 infection. Having used a variety cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report first evidence that latently infects early bone marrow progenitor may be transmitted longitudinally to which differentiate along committed pathways.
Several chronic inflammatory conditions and genetic alterations are likely to be involved in the pathogenesis of low‐grade lymphoma MALT type. In a well‐characterized series 27 patients with type, we studied: (1) incidence other neoplasms, which might indicative instability, apparently characteristic this disease; (2) prevalence serologic molecular markers HCV infection, has been found association lymphoproliferative disorders. Three had one or more additional cancers; total eight tumours,...
Syncytial giant-cell hepatitis is a rare but severe form of that associated with autoimmune diseases, drug reactions, and viral infections. We used serologic, molecular, immunohistochemical methods to search for an infectious cause in case syncytial developed liver-transplant recipient who had latent infection variant B human herpesvirus 6 (HHV-6B) received the organ from donor A (HHV-6A). At onset disease, detection HHV-6A (but not HHV-6B) DNA plasma, affected liver tissue, single...
Several studies in mouse model of invasive aspergillosis (IA) and healthy donors have shown that different Aspergillus antigens may stimulate adaptive immune responses. However, the occurrence Aspergillus-specific T cells not yet been reported patients with disease. In IA, we investigated during infection: a) whether how specific T-cell responses to occur develop; b) which elicit highest frequencies protective and, c) such could be expanded ex-vivo. Forty hematologic studied, including 22 IA...
Abstract Out of 64 cases non‐Hodgkin's lymphomas (NHL), 55 Hodgkin's disease (HD) and 31 multiple sclerosis (MS), 2 NHL, 7 HD 1 MS were found positive by polymerase chain reaction (PCR) for the presence HHV‐6 sequences in pathologic lymph nodes peripheral blood mononuclear cells (PBMCs) MS. A further analysis PBMCs PCR standard Southern blot technique revealed only 3 as positive, indicating that these six patients have an unusually high viral copy number PBMCs. Restriction analysis, carried...
We report the occurrence of human herpesvirus (HHV)-8 primary infection in an adult male kidney recipient. Four months after transplantation, patient developed visceral Kaposi sarcoma, and 1 month later he presented with progressive severe peripheral cytopenia, presence a normocellular or hypercellular bone marrow (BM) hemophagocytosis. HHV-8 was sole pathogen detected by polymerase chain reaction either serum BM. latent nuclear antigen immature progenitor cells from Immunosuppressive...
Infections represent a cause of morbidity and mortality in patients affected by chronic lymphocytic leukemia (CLL). Introduction new drugs CLL clinical practice has showed impressive efficacy, particular those targeting BTK. Among the consistent data, an increasing number reports describing occurrence unexpected opportunistic fungal infections been reported during treatment with ibrutinib first 6 months treatment. The reason underlying manifestations invasive treated is still under...