A5024712234- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Pediatric Urology and Nephrology Studies
- Mesenchymal stem cell research
- Urological Disorders and Treatments
- Boron Compounds in Chemistry
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Protein Kinase Regulation and GTPase Signaling
- Boron and Carbon Nanomaterials Research
- Urinary and Genital Oncology Studies
- Social Media in Health Education
- Titanium Alloys Microstructure and Properties
- Shoulder and Clavicle Injuries
- Chemokine receptors and signaling
- Congenital gastrointestinal and neural anomalies
- Signaling Pathways in Disease
- Neurogenetic and Muscular Disorders Research
- Extracellular vesicles in disease
- Radiation Therapy and Dosimetry
- Muscle Physiology and Disorders
Universidade Federal de Minas Gerais
2017-2024
Albert Einstein College of Medicine
2023
Centro de Desenvolvimento da Tecnologia Nuclear
2021
Universidade Federal do Amazonas
2021
Yale University
2019
Universidade Federal do Espírito Santo
2019
Pontifícia Universidade Católica do Rio Grande do Sul
2016
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014
Long circulating pH-sensitive liposomes have been shown to effectively deliver doxorubicin (DOX) tumors and reduce its toxic effects. Folic acid receptors are upregulated in a wide variety of solid, epithelial tumors, including breast cancer. In order improve liposomal endocytosis antitumor activity, folic has added nanoparticles surfaces exploit overexpression folate tumor cells. The purpose this study was evaluate the activity vitro vivo long folate-coated DOX-loaded (SpHL-DOX-Fol) 4T1...
Mesenchymal stem/stromal cells (MSCs) are promising tools in cell therapy. They secrete extracellular vesicles (EVs) that carry different classes of molecules can promote skin repair, but the mechanisms poorly understood. Skin wound healing is a complex process requires activity several signaling pathways and types, including keratinocytes fibroblasts. In this study, we explored whether adipose tissue MSC-derived EVs could accelerate migration proliferation fibroblasts, activate AKT pathway,...
Currently, nanostructured compounds have been standing out for their optical, mechanical, and chemical features the possibilities of manipulation regulation complex biological processes. One these is boron nitride nanotubes (BNNTs), which are a material analog to carbon nanotubes, but formed nitrogen atoms. BNNTs present high thermal stability along with inertia. Among applications, its biocompatibility, cellular uptake, functionalization potential can be highlighted, in addition eased...
Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. While emerging evidence suggests that CSCs have a unique dependency on lipid metabolism, the functions regulation of distinct species in remain poorly understood. Here, we developed cell factor SOX9-based reporter for isolating primary tumors metastases spontaneous mammary models. Transcriptomic analyses uncover SOX9 high up-regulate ABCA12 transporter. down-regulation impairs cancer stemness Lipidomic reveal...
Abstract Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities therapeutic properties in glass network. Among many that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering formation new blood vessels by vascular endothelial growth factor A ( VEGFA ), due to stabilizing effect on hypoxia inducible 1 subunit alpha HIF1A an...
Cancer is one of the main causes death in world and thus a global public health problem. Among treatments available for cancer are surgery, radiotherapy, chemotherapy. Currently, there increased interest combination two or more antitumor agents to achieve synergistic effect therapy. Doxorubicin (DOX), chemotherapeutic which has potent antineoplastic action, been used treatment various tumors. However, use DOX limited, mainly due cardiotoxicity. Therefore, nanostructured systems, such as...
Abstract In this study, we report the production of a mesoporous silica/hydroxyapatite‐based nanocomposite containing copper (Cu) functionalized with methacrylic acid (MAA), pH‐sensitive polymer. The functionalization nanoparticles surface was performed using microwave method in order to anchor cross‐linking tetraethylene glycol dimethacrylate (TEGDMA), onto followed by MAA polymerization. materials were characterized XRD, XRF spectroscopy, scanning and transmission electron microscopy,...
Abstract Hydroxyapatite (HA) nanoparticles have been studied due to their high biocompatibility, similarity with bone tissue, and capacity for regeneration since these can easily adhere on osteosarcoma osteoblast cells, promoting growth cell uptake. These materials may still accumulate spontaneously selectively in regions of tumors through the enhanced permeability retention effect. HA also allows incorporation strontium your network. Strontium as a biochemical analog calcium maintain...
Abstract Breast cancer is the most common in women. Although chemotherapy still broadly used its treatment, adverse effects remain a challenge. In this scenario, aptamers emerge as promising alternative for theranostic applications. Studies using breast cell lines provide useful information laboratory and preclinical investigations, of which use established from metastatic sites. However, these correspond to populations late stage tumor progression. On other hand, studies cells primary sites...
Since the possibility of silencing specific genes linked to retinal degeneration has become a reality with use small interfering RNAs (siRNAs), this technology been widely studied promote treatment several ocular diseases. Despite recent advances, clinical success gene in retina is significantly reduced by inherent anatomical and physiological barriers, new strategies are required achieve intraocular therapeutic effectiveness. In study, we developed lipoplexes, prepared sodium alginate as an...
The skin is the largest organ in human body that acts as a protective barrier from outside environment. Certain dermatological pathologies or significant lesions can result serious complications. Several studies have focused on development of tissue-engineered substitutes. In this study, new bilayer scaffold composed chitosan-gelatin membrane and chitosan-polyhydroxybutyrate (PHB) porous matrix was synthesized populated with adipose-derived mesenchymal stem cells (hASCs) to be potentially...
Human adipose‐derived stromal/stem cells (ASC) have immunomodulatory properties and the potential to differentiate into several cell lines, important for application in regenerative medicine. However, contamination with dermal fibroblasts (FIB) can impair beneficial effects of ASC therapy. It is then essential develop new strategies that contribute distinction between these two types. In this study, we performed functional assays, high‐throughput RNA sequencing (RNA‐Seq) quantitative PCR...
Aim: The field of nanotechnology promotes the development innovative and more effective cancer therapies. This work is aimed to develop a hybrid system that combines capacity boron nitride nanotubes (BNNTs) be internalized by tumor cells ability nickel ferrite nanoparticles efficiently release heat induced AC magnetic heating. Materials & methods: systems studied were characterized using x-ray diffractometry, transmission electron microscopy, vibrating sample magnetometry Mössbauer...
You have accessJournal of Urology1 Apr 2008LAPAROSCOPIC PYELOLITHOTOMY IN A PELVIC KIDNEY Angelo Baccala, Vairavan S Subramanian, Marcelo Miranda, and Mihir M Desai BaccalaAngelo Baccala More articles by this author , SubramanianVairavan Subramanian MirandaMarcelo Miranda DesaiMihir View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60457-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "LAPAROSCOPIC KIDNEY."...
Cathodic cage, operating in the plasma nitriding mode, has been widely applied to improve mechanical properties of steel surfaces. This paper investigated use this method for deposition titanium nitride films on a glass substrate, demonstrating its promising application nanostructured materials with good electrical and optical properties. 300 nm thick were grown varying N2/H2 gas ratio fixed working pressure 1 Torr cage temperature 460 °C. The formation single-phase tetragonal δ'-Ti2 − xN...